Structure. The substantia nigra is the midbrain's pigmented plate between tegmentum and cerebral peduncle — the compacta's dark dopaminergic neurons (neuromelanin) face the peduncle, the reticulata's GABAergic sheet faces the striatum; it arches the whole midbrain length.
Function. Dopamine's motor gate: nigrostriatal compacta neurons tonically license striatal action selection — their loss IS Parkinson's disease (rigidity, tremor, bradykinesia), while reticulata output mirrors pallidal suppression. The same neurons die in Parkinson-plus syndromes and are the substrate of dopaminergic therapy.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Ongoing post-surgical pain raised rCBF in a midbrain tegmental cluster including the substantia nigra (with VT |
| pain-induction | assessor | secondary | standard-scientific | fMRI | pCASL perfusion fMRI measured reproducible pre/post-surgical rCBF increases in a midbrain tegmental cluster th |
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| The role of cognitive reappraisal in placebo analgesia: an fMRI study PMID 28338955 |
| Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance PMID 28344549 |
| Neural correlates of emotional inhibitory control in autism spectrum disorders PMID 28359873 |
| Functional magnetic resonance imaging investigation of brain regions associated with astringency PMID 28366831 |
| Strategic Motives Drive Proposers to Offer Fairly in Ultimatum Games: An fMRI Study PMID 28373714 |
| Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis PMID 28392491 |
| Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea PMID 28392711 |
| Neural evidence for the intrinsic value of action as motivation for behavior PMID 28396007 |
| The brain anatomy of attention-deficit/hyperactivity disorder in young adults – a magnetic resonance imaging study PMID 28406942 |
| Social Interaction Affects Neural Outcomes of Sign Language Learning As a Foreign Language in Adults PMID 28408872 |
| Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation m PMID 28413706 |
| Reactivation or transformation? Motor memory consolidation associated with cerebral activation time-locked to sleep spin PMID 28422976 |
| Patterns of brain and cardiovascular activation while solving rule-discovery and rule-application numeric tasks PMID 28431987 |
| Mental arithmetic in the bilingual brain: Language matters PMID 28495598 |
| Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic ciga PMID 28528203 |
| Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder PMID 28529870 |
| Modes of Effective Connectivity within Cortical Pathways Are Distinguished for Different Categories of Visual Context: A PMID 28588458 |
| Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study PMID 28626785 |
| Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems PMID 28654776 |
| Avoidant Responses to Interpersonal Provocation Are Associated with Increased Amygdala and Decreased Mentalizing Network PMID 28660251 |
| Anomalous prefrontal-limbic activation and connectivity in youth at high-risk for bipolar disorder PMID 28667891 |
| Active avoidance and attentive freezing in the face of approaching threat PMID 28669911 |
| Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task PMID 28744228 |
| The levels of perceptual processing and the neural correlates of increasing subjective visibility PMID 28823896 |
| Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study PMID 28828187 |
| Independent circuits in basal ganglia and cortex for the processing of reward and precision feedback PMID 28870852 |
*Brainstem · Mai atlas of record · 775 studies · 186 papers on disk*
The right substantia nigra — the mirror plate, with 186 papers (the mirror's own literature adds the asymmetry studies) and a decoded profile carrying dopaminergic as a term of its own.
The substantia nigra is the midbrain's pigmented plate between tegmentum and cerebral peduncle — the compacta's dark dopaminergic neurons (neuromelanin) face the peduncle, the reticulata's GABAergic sheet faces the striatum; it arches the whole midbrain length.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'midbrain, substantia nigra'}*
Dopamine's motor gate: nigrostriatal compacta neurons tonically license striatal action selection — their loss IS Parkinson's disease (rigidity, tremor, bradykinesia), while reticulata output mirrors pallidal suppression. The same neurons die in Parkinson-plus syndromes and are the substrate of dopaminergic therapy.
The functional record mirrors the left's: nigrostriatal licensing, Parkinson's identity. No graded instrument is assigned to this dossier yet — the reward family's records live on the left twin; the right nigra's own grading is an open slot.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 8, Action'}*
Red nucleus (1,045 shared studies), midbrain (1,009), superior colliculus (898), cerebral aqueduct (664), the mirror nigra (657) — the tegmental row, mirrored.
Co-activation partners of record: Red nucleus:1045, Midbrain:1009, Superior colliculus:898, Cerebral aqueduct:664, Substantia nigra:657, Red nucleus:650, Mammillary body:554, Thalamus:458.
The mirror Parkinson's story; the right nigra's asymmetries (motor vs. motivational dopamine) remain an active question, recorded as such.
The right plate's asymmetry question is also a technique question: neuromelanin-sensitive MRI images the nigra's dopamine content directly, and the right-versus-left motor-motivational split is being re-measured with it. The 186-paper dossier (36 more than the left's) tracks the asymmetric-degeneration studies in Parkinson's — the side that dominates symptoms first.
10.1016/S0896-6273(00)80476-610.1016/S0006-3223(99)00056-610.1016/S0028-3932(99)00132-3775 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — reward(method-other), pain(interoception), midbrain(anatomy-reference), brainstem(anatomy-reference), dopaminergic(drug-pharmacology), nucleus(anatomy-reference), striatum(method-other), responses(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Red nucleus:1045, Midbrain:1009, Superior colliculus:898, Cerebral aqueduct:664 — each name is a dossier stop in this explorer.