Structure. The corpus callosum is the brain's great commissural cable — roughly 200 million axons arched as rostrum, genu, body and splenium above the ventricles, each fibre joining mirror-image (and heterotopic) cortical zones; the genu's forceps minor fronts the frontal lobes, the splenium's forceps major reaches occipital cortex.
Function. The hemispheres' dialogue: callosal transfer integrates split-field perception (its surgical section — split-brain — isolates each hemisphere's awareness), paces bimanual coordination, and its developmental absence (agenesis) reveals each hemisphere's partial autonomy.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stopsignal ↗ | assessor | secondary | standard-scientific | fMRI | Stop-signal fMRI in adolescents with and without ADHD showed right-IFG reactive stopping and opposite prospect |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Reward is the region's top decoded term (0.008) with anticipation third; on disk, youth at high familial risk |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | In a risky-decision game (cautious 1-cent vs risky 5-cent gain / 10-cent loss), antisocial-substance-disorder |
| pain-induction | assessor | secondary | standard-scientific | fMRI | fMRI of noxious heat pain showed activation of supraspinal pain areas that electroacupuncture preferentially d |
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| Experience-dependent neural substrates involved in vocal pitch regulation during singing. NeuroImage 2008 · 10.1016/j.neuroimage.2008.01.026 |
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| Ipsilateral cortical representation of tactile and painful information in acallosal and callosotomized subjects. Neuropsychologia 2008 · 10.1016/j.neuropsychologia.2008.02.017 |
| Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 · 10.1523/JNEUROSCI.3921-07.2008 |
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| The neural basis of academic achievement motivation. NeuroImage 2008 · 10.1016/j.neuroimage.2008.04.253 |
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| It's Sad but I Like It: The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00676 |
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| Off to a Good Start: The Early Development of the Neural Substrates Underlying Visual Working Memory. Frontiers in systems neuroscience 2016 · 10.3389/fnsys.2016.00068 |
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| Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory. Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00540 |
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| Neural correlates of the affective properties of spontaneous and volitional laughter types. Neuropsychologia 2017 · 10.1016/j.neuropsychologia.2016.12.012 |
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| Sensory cortical response to uncertainty and low salience during recognition of affective cues in musical intervals. PloS one 2017 · 10.1371/journal.pone.0175991 |
| White Matter Integrity and Treatment-Based Change in Speech Performance in Minimally Verbal Children with Autism Spectru Frontiers in human neuroscience 2017 · 10.3389/fnhum.2017.00175 |
| Influence of response bias and internal/external source on lateral posterior parietal successful retrieval activity. Cortex; a journal devoted to the study of the nervous system and behavior 2017 · 10.1016/j.cortex.2017.04.002 |
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| Neural Activity Patterns in the Human Brain Reflect Tactile Stickiness Perception. Frontiers in human neuroscience 2017 · 10.3389/fnhum.2017.00445 |
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| The Neural Correlates of Mental Rotation Abilities in Cannabis-Abusing Patients with Schizophrenia: An fMRI Study PMID 23970971 |
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| Differences in Neural Activation for Object-Directed Grasping in Chimpanzees and Humans PMID 23986247 |
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| Basal forebrain moderates the magnitude of task-dependent amygdala functional connectivity PMID 24847112 |
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| Sparse regularization techniques provide novel insights into outcome integration processes PMID 25467302 |
| Functional connectivity density alterations in schizophrenia PMID 25477799 |
| Frontoparietal networks involved in categorization and item working memory PMID 25482265 |
| Neural activation during response inhibition is associated with adolescents' frequency of risky sex and substance use PMID 25532443 |
| Altered neural connectivity during response inhibition in adolescents with attention-deficit/hyperactivity disorder and PMID 25610797 |
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| Tinnitus: A Large VBM-EEG Correlational Study PMID 25781934 |
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| fMRI reveals neural activity overlap between adult and infant pain PMID 25895592 |
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| Common and distinct neural effects of risperidone and olanzapine during procedural learning in schizophrenia: a randomis PMID 25980483 |
| Language Differences in the Brain Network for Reading in Naturalistic Story Reading and Lexical Decision PMID 26017384 |
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| Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference PMID 26025014 |
| Neural correlates of active vision: An fMRI comparison of natural reading and scene viewing PMID 26026255 |
| Identifying brain functional alterations in postmenopausal women with cognitive impairment PMID 26037032 |
| Abnormal amygdala function in Parkinson's disease patients and its relationship to depression PMID 26042728 |
| Connectivity pattern differences bilaterally in the cerebellum posterior lobe in healthy subjects after normal sleep and PMID 26064046 |
| Affective mapping: An activation likelihood estimation (ALE) meta-analysis PMID 26074298 |
| Autobiographical planning and the brain: Activation and its modulation by qualitative features PMID 26102226 |
| Functional connectivity underlying postural motor adaptation in people with multiple sclerosis PMID 26106552 |
| The mediating role of LPFC–vmPFC functional connectivity in the relation between regulatory mode and delay discounting PMID 26116812 |
| Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study PMID 26161117 |
| Separate and overlapping brain areas encode subjective value during delay and effort discounting PMID 26163803 |
| The effects of age, sex, and hormones on emotional conflict-related brain response during adolescence PMID 26175008 |
| Aberrant functioning of the putamen links delusions, antipsychotic drug dose, and compromised connectivity in first epis PMID 26184459 |
| Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode PMID 26192817 |
| Resting Spontaneous Activity in the Default Mode Network Predicts Performance Decline during Prolonged Attention Workloa PMID 26196666 |
| Atypical processing of voice sounds in infants at risk for autism spectrum disorder PMID 26200892 |
| White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration PMID 26236629 |
| The nature of the language input affects brain activation during learning from a natural language PMID 26257471 |
| The relationship between the neural computations for speech and music perception is context-dependent: an activation lik PMID 26321976 |
| Role of local and distant functional connectivity density in the development of minimal hepatic encephalopathy PMID 26329994 |
| The duality of temporal encoding – the intrinsic and extrinsic representation of time PMID 26379604 |
| “Shall I compare thee”: The neural basis of literary awareness, and its benefits to cognition PMID 26409018 |
| Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit h PMID 26509118 |
| Aberrant functioning of the theory-of-mind network in children and adolescents with autism PMID 26512314 |
| A cortical network that marks the moment when conscious representations are updated PMID 26529489 |
| "Divergent subcortical activity for distinct executive functions: stopping and PMID 26541510 |
| Is it me? Verbal self-monitoring neural network and clinical insight in schizophrenia PMID 26549744 |
| Default network activation during episodic and semantic memory retrieval: A selective meta-analytic comparison PMID 26562053 |
| Past experience shapes ongoing neural patterns for language PMID 26624517 |
| The shaping of social perception by stimulus and knowledge cues to human animacy PMID 26644594 |
| The influence of self-awareness on emotional memory formation: an fMRI study PMID 26645274 |
| Auditory Spatial Coding Flexibly Recruits Anterior, but Not Posterior, Visuotopic Parietal Cortex PMID 26656996 |
| It's Sad but I Like It: The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons PMID 26778996 |
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| Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment PMID 26839078 |
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| Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome PMID 27114901 |
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| Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder PMID 27187232 |
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*Frontal lobe · Mai atlas of record · 643 studies · 156 papers on disk*
The corpus callosum is the brain's great commissural cable — roughly 200 million axons arched as rostrum, genu, body and splenium, each joining mirror-image cortex. Cut it, and the mind's two halves become two minds — the split-brain patients who taught us where awareness sits.
The corpus callosum is the brain's great commissural cable — roughly 200 million axons arched as rostrum, genu, body and splenium above the ventricles, each fibre joining mirror-image (and heterotopic) cortical zones; the genu's forceps minor fronts the frontal lobes, the splenium's forceps major reaches occipital cortex.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y −50.7…+43.7 mm, 30 plates (labels cc)'}*
The hemispheres' dialogue: callosal transfer integrates split-field perception (its surgical section — split-brain — isolates each hemisphere's awareness), paces bimanual coordination, and its developmental absence (agenesis) reveals each hemisphere's partial autonomy.
The functional record: callosal transfer integrates split-field perception, paces bimanual coordination, and its developmental absence (agenesis) rewires the hemispheres' dialogue entirely. The decoded profile is unexpected — reward, caudate, anticipation, striatal — because the body-of-callosum region's literature overlaps the striatal and ventricular anatomy around it. No graded instrument is assigned — a cable's dossier is a tract-tracing story, not a task story.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 4, Hemispheric Specialization'}*
Paraterminal gyrus (1,006 shared studies), third ventricle (457), fornix (427), anterior cingulate (380), caudate (368) — the midline neighbors of the great arch.
Co-activation partners of record: Paraterminal gyrus:1006, Third ventricle:457, Fornix:427, Cingulate gyrus, anterior:380, Caudate nucleus:368, Thalamus:316, Intraparietal sulcus:246, Paracingulate gyrus:242.
Split-brain: the surgical section that isolates each hemisphere's awareness — the most philosophically loaded lesion in neuroscience, and it is this cable's failure-mode.
10.1136/jnnp.66.1.3610.1093/cercor/9.1.3510.1073/pnas.96.16.940310.1093/cercor/10.1.2643 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — reward(method-other), caudate(anatomy-reference), anticipation(cognition), striatal(method-other), thalamus(method-other), nucleus(anatomy-reference), adults(method-other), cingulate(anatomy-reference) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Paraterminal gyrus:1006, Third ventricle:457, Fornix:427, Cingulate gyrus, anterior:380 — each name is a dossier stop in this explorer.