Structure. The superior colliculus is the rostral pair of the midbrain tectum's four hillocks — layered (seven-strata) sensory-motor integrative domes receiving retinal and cortical input, discharging through tectospinal and tecto-bulbar routes, with the pretectum just rostral.
Function. The saccade map: a retinotopic canvas on which gaze targets are chosen and launched (express saccades without cortical blessing), plus multimodal salience capture — its depth-electrode bursts precede every reflexive glance.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| pain-induction | assessor | secondary | standard-scientific | behavioral | sc-r's decoded profile is led by pain (0.021) with periaqueductal, insula and noxious terms nearby. An on-disk |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Profile holds reward (0.018), anticipation, prediction error and dopaminergic, and sc-r's top co-activation is |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Profile carries aversive, unpleasant and reward terms alongside the top reward term. The on-disk reversal-lear |
| gonogo ↗ | assessor | secondary | standard-scientific | fMRI | Profile terms response inhibition, inhibition, stop and stop signal tie sc-r to prepotent-response control. Th |
| simple-rt ↗ | assessor | secondary | standard-scientific | behavioral | An on-disk human SC fMRI study shows the re-centering bias directly: SC activity drops while saccadic reaction |
| oddball ↗ | assessor | secondary | standard-scientific | fMRI | sc-r's profile holds novelty and salience terms and its densest co-activation is midbrain (1,104). The on-disk |
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| The Saccadic Re-Centering Bias is Associated with Activity Changes in the Human Superior Colliculus. Frontiers in human neuroscience 2010 · 10.3389/fnhum.2010.00193 |
| Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.2590-10.2010 |
| Learning from other people's experience: a neuroimaging study of decisional interactive-learning. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.065 |
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| Affective response to a loved one's pain: insula activity as a function of individual differences. PloS one 2010 · 10.1371/journal.pone.0015268 |
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| Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsq092 |
| The brain reaction to viewing faces of opposite- and same-sex romantic partners. PloS one 2010 · 10.1371/journal.pone.0015802 |
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| Investigation of the neural control of cough and cough suppression in humans using functional brain imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 · 10.1523/JNEUROSCI.4597-10.2011 |
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| Linking coordinative and executive dysfunctions to atrophy in spinocerebellar ataxia 2 patients. Brain structure & function 2011 · 10.1007/s00429-011-0310-4 |
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| Defining face perception areas in the human brain: a large-scale factorial fMRI face localizer analysis. Brain and cognition 2012 · 10.1016/j.bandc.2012.01.001 |
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| Situation and person attributions under spontaneous and intentional instructions: an fMRI study. Social cognitive and affective neuroscience 2013 · 10.1093/scan/nss022 |
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| Thirst and the state-dependent representation of incentive stimulus value in human motive circuitry. Social cognitive and affective neuroscience 2015 · 10.1093/scan/nsv063 |
| Slow breathing and hypoxic challenge: cardiorespiratory consequences and their central neural substrates. PloS one 2015 · 10.1371/journal.pone.0127082 |
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| Neural Correlates of Hostile Jokes: Cognitive and Motivational Processes in Humor Appreciation. Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00527 |
| Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder. Neuropsychologia 2016 · 10.1016/j.neuropsychologia.2016.11.005 |
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| Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance. Frontiers in systems neuroscience 2017 · 10.3389/fnsys.2017.00011 |
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| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Episodic specificity induction impacts activity in a core brain network during construction of imagined future experienc PMID 27601666 |
| Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation PMID 27622387 |
| Charting the effects of TMS with fMRI: Modulation of cortical recruitment within the distributed network supporting sema PMID 27650816 |
| An individual differences analysis of the neurocognitive architecture of the semantic system at rest PMID 27662589 |
| The retrieval of perceptual memory details depends on right hippocampal integrity and activation PMID 27665526 |
| Alpha oscillation neurofeedback modulates amygdala complex connectivity and arousal in posttraumatic stress disorder PMID 27672554 |
| Neural Activities Underlying the Feedback Express Salience Prediction Errors for Appetitive and Aversive Stimuli PMID 27694920 |
| The association of serotonin receptor 3A methylation with maternal violence exposure, neural activity, and child aggress PMID 27720744 |
| A neural mechanism of cognitive control for resolving conflict between abstract task rules PMID 27771559 |
| Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder PMID 27842291 |
| Filtering and storage working memory networks in younger and older age PMID 27843697 |
| Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in PMID 27845765 |
| Sex differences in emotional perception: Meta analysis of divergent activation PMID 27988321 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| Lost emotion: Disrupted brain-based tracking of dynamic affective episodes in anxiety and depression PMID 28013067 |
| Predicting the Multisensory Consequences of One’s Own Action: BOLD Suppression in Auditory and Visual Cortices PMID 28060861 |
| Distinct cortico-striatal connections with subthalamic nucleus underlie facets of compulsivity PMID 28103527 |
| A variance components model for statistical inference on functional connectivity networks PMID 28130192 |
| FMRI activity during associative encoding is correlated with cardiorespiratory fitness and source memory performance in PMID 28161031 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| Activity and connectivity of the cerebellum in trigeminal nociception PMID 28192274 |
| Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson's Disease PMID 28232858 |
| A direct comparison of appetitive and aversive anticipation: Overlapping and distinct neural activation PMID 28267576 |
| Altered functional connectivity in brain networks underlying self-referential processing in delusions of reference in sc PMID 28315577 |
| Tribal love: the neural correlates of passionate engagement in football fans PMID 28338882 |
| The role of cognitive reappraisal in placebo analgesia: an fMRI study PMID 28338955 |
| Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance PMID 28344549 |
| Functional magnetic resonance imaging investigation of brain regions associated with astringency PMID 28366831 |
| Strategic Motives Drive Proposers to Offer Fairly in Ultimatum Games: An fMRI Study PMID 28373714 |
| Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis PMID 28392491 |
| Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea PMID 28392711 |
| Neural evidence for the intrinsic value of action as motivation for behavior PMID 28396007 |
| The brain anatomy of attention-deficit/hyperactivity disorder in young adults – a magnetic resonance imaging study PMID 28406942 |
| Patterns of brain and cardiovascular activation while solving rule-discovery and rule-application numeric tasks PMID 28431987 |
| Mental arithmetic in the bilingual brain: Language matters PMID 28495598 |
| Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic ciga PMID 28528203 |
| Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder PMID 28529870 |
| Modes of Effective Connectivity within Cortical Pathways Are Distinguished for Different Categories of Visual Context: A PMID 28588458 |
| Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study PMID 28626785 |
| Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems PMID 28654776 |
| Avoidant Responses to Interpersonal Provocation Are Associated with Increased Amygdala and Decreased Mentalizing Network PMID 28660251 |
| Anomalous prefrontal-limbic activation and connectivity in youth at high-risk for bipolar disorder PMID 28667891 |
| Neural correlates of prosocial behavior towards persons in pain in healthcare providers PMID 28669784 |
| Active avoidance and attentive freezing in the face of approaching threat PMID 28669911 |
| Dissonance encoding in human inferior colliculus covaries with individual differences in dislike of dissonant music PMID 28720776 |
| Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task PMID 28744228 |
| The Effect of Suspense on Brain Activation and Memory During Naturalistic Viewing PMID 28764896 |
| Independent circuits in basal ganglia and cortex for the processing of reward and precision feedback PMID 28870852 |
*Brainstem · Mai atlas of record · 790 studies · 150 papers on disk*
The superior colliculus is the rostral pair of the midbrain tectum's four hillocks — a seven-strata sensory-motor integrative dome receiving retinal and cortical input, dispatching gaze. It is the saccade map: a retinotopic canvas on which gaze targets are chosen and launched — express saccades fire without cortical blessing.
The superior colliculus is the rostral pair of the midbrain tectum's four hillocks — layered (seven-strata) sensory-motor integrative domes receiving retinal and cortical input, discharging through tectospinal and tecto-bulbar routes, with the pretectum just rostral.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'midbrain, tectum'}*
The saccade map: a retinotopic canvas on which gaze targets are chosen and launched (express saccades without cortical blessing), plus multimodal salience capture — its depth-electrode bursts precede every reflexive glance.
The functional record: the saccade map plus multimodal salience capture. Its decoded profile is the midbrain's defensive-motivational row — pain, reward, response, amygdala — the colliculus sits inside the startle-and-defence circuitry. No graded instrument is assigned; the gaze levers (antisaccade, ANT) are recorded on the frontal eye field's dossier, the cortex this dome obeys and outmanoeuvres.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 7, Attention'}*
Midbrain (1,104 shared studies), cerebral aqueduct (989), substantia nigra (874), red nucleus (786+665) — the tegmental row, ceiling to floor.
Co-activation partners of record: Midbrain:1104, Cerebral aqueduct:989, Substantia nigra:874, Red nucleus:786, Substantia nigra:665, Inferior colliculus:608, Red nucleus:598, Mammillary body:468.
The colliculus's lesion signs are subtle in humans (the cortex compensates); its stimulation story — gaze evoked, salience captured — is the comparative literature's. The honest note: the human SC's dossier is its neighbours', plus the express-saccade experiments.
10.1016/S0896-6273(00)80476-610.1016/S0006-3223(99)00056-6790 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — pain(interoception), reward(method-other), midbrain(anatomy-reference), brainstem(anatomy-reference), response(method-other), striatum(method-other), responses(method-other), amygdala(anatomy-reference) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Midbrain:1104, Cerebral aqueduct:989, Substantia nigra:874, Red nucleus:786 — each name is a dossier stop in this explorer.