Structure. The substantia nigra is the midbrain's pigmented plate between tegmentum and cerebral peduncle — the compacta's dark dopaminergic neurons (neuromelanin) face the peduncle, the reticulata's GABAergic sheet faces the striatum; it arches the whole midbrain length.
Function. Dopamine's motor gate: nigrostriatal compacta neurons tonically license striatal action selection — their loss IS Parkinson's disease (rigidity, tremor, bradykinesia), while reticulata output mirrors pallidal suppression. The same neurons die in Parkinson-plus syndromes and are the substrate of dopaminergic therapy.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| reward-prediction ↗ | stimulator | primary | highly-credible | delivery | Substantia nigra dopamine neurons carry the prediction-error itself. |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| pain-induction | stimulator | secondary | standard-scientific | delivery | On-disk chronic-pain fMRI (Picture & Imagination Task, PHODA-based): patients vs controls showed increased BOL |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Same on-disk PIT study: left SN/VT BOLD rose in chronic musculoskeletal pain patients versus healthy controls |
| simple-rt ↗ | stimulator | secondary | standard-scientific | delivery | Decoded profile of record associates sn-l with arousal (0.0043) and responses (0.0058): simple-RT paradigms pr |
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| Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex Neuropsychologia 2007 · 10.1016/j.neuropsychologia.2007.06.011 |
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| Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proceedings of the National Academy of Sciences of the United States of America 2007 · 10.1073/pnas.0706481104 |
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| Sucrose activates human taste pathways differently from artificial sweetener. NeuroImage 2008 · 10.1016/j.neuroimage.2007.10.061 |
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| Neural circuitry for accurate identification of facial emotions. Brain research 2008 · 10.1016/j.brainres.2007.10.105 |
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| A new verbal reports fMRI dichotic listening paradigm for studies of hemispheric asymmetry. NeuroImage 2008 · 10.1016/j.neuroimage.2007.11.051 |
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| Acupuncture modulates resting state connectivity in default and sensorimotor brain networks. Pain 2008 · 10.1016/j.pain.2008.01.011 |
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| Modulation of brain resting-state networks by sad mood induction. PloS one 2008 · 10.1371/journal.pone.0001794 |
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| Craving love? Enduring grief activates brain's reward center. NeuroImage 2008 · 10.1016/j.neuroimage.2008.04.256 |
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| Abnormal temporal difference reward-learning signals in major depression. Brain : a journal of neurology 2008 · 10.1093/brain/awn136 |
| Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia. Behavioural brain research 2008 · 10.1016/j.bbr.2008.05.012 |
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| Neural networks for short-term memory for order differentiate high and low proficiency bilinguals. NeuroImage 2008 · 10.1016/j.neuroimage.2008.06.003 |
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| Dorsal striatal-midbrain connectivity in humans predicts how reinforcements are used to guide decisions. Journal of cognitive neuroscience 2009 · 10.1162/jocn.2009.21092 |
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| Tuning-in to the beat: Aesthetic appreciation of musical rhythms correlates with a premotor activity boost. Human brain mapping 2010 · 10.1002/hbm.20844 |
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| Delineating self-referential processing from episodic memory retrieval: common and dissociable networks. NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.087 |
| Contextual novelty changes reward representations in the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.5331-09.2010 |
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| Identifying the what, why, and how of an observed action: an fMRI study of mentalizing and mechanizing during action obs Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21446 |
| Mental hoop diaries: emotional memories of a college basketball game in rival fans. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.2481-09.2010 |
| Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia. Psychiatry research 2010 · 10.1016/j.pscychresns.2009.10.012 |
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| Action selection: a race model for selected and non-selected actions distinguishes the contribution of premotor and pref NeuroImage 2010 · 10.1016/j.neuroimage.2010.02.045 |
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| Basal ganglia hypoactivity during grip force in drug naive Parkinson's disease. Human brain mapping 2010 · 10.1002/hbm.20987 |
| Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems. Pain 2010 · 10.1016/j.pain.2010.01.006 |
| The effect of semantic relatedness on syntactic analysis: An fMRI study. Brain and language 2010 · 10.1016/j.bandl.2010.02.001 |
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| What does the right hemisphere know about phoneme categories? Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21495 |
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| Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.04.011 |
| Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in childre Biological psychiatry 2010 · 10.1016/j.biopsych.2010.02.020 |
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| Reward, addiction, and emotion regulation systems associated with rejection in love. Journal of neurophysiology 2010 · 10.1152/jn.00784.2009 |
| Age-related functional changes in gustatory and reward processing regions: An fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.012 |
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| Evaluating an acoustically quiet EPI sequence for use in fMRI studies of speech and auditory processing. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.015 |
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| Brain responses to facial expressions of pain: emotional or motor mirroring? NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.037 |
| Structural and functional bases for individual differences in motor learning. Human brain mapping 2011 · 10.1002/hbm.21037 |
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| Neural substrates of phasic alertness: a functional magnetic resonance imaging study. Neuroscience research 2010 · 10.1016/j.neures.2010.05.005 |
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| Activity in the hippocampus and neocortical working memory regions predicts successful associative memory for temporally Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.07.025 |
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| The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudina Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq140 |
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| Lateralization of speech production starts in sensory cortices--a possible sensory origin of cerebral left dominance for Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq167 |
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| fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level. Brain imaging and behavior 2011 · 10.1007/s11682-010-9106-z |
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| From language comprehension to action understanding and back again. Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq189 |
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| When music and long-term memory interact: effects of musical expertise on functional and structural plasticity in the hi PloS one 2010 · 10.1371/journal.pone.0013225 |
| Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociatio The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3323-10.2010 |
| The role of the dorsolateral prefrontal cortex in deception when remembering neutral and emotional events. Neuroscience research 2011 · 10.1016/j.neures.2010.11.001 |
| Experiential, autonomic, and neural responses during threat anticipation vary as a function of threat intensity and neu NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.040 |
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| Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standard NeuroImage 2011 · 10.1016/j.neuroimage.2010.12.004 |
| Face-Specific Resting Functional Connectivity between the Fusiform Gyrus and Posterior Superior Temporal Sulcus. Frontiers in human neuroscience 2010 · 10.3389/fnhum.2010.00176 |
| Complementary roles of systems representing sensory evidence and systems detecting task difficulty during perceptual dec Frontiers in neuroscience 2010 · 10.3389/fnins.2010.00190 |
| Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsq092 |
| The brain reaction to viewing faces of opposite- and same-sex romantic partners. PloS one 2010 · 10.1371/journal.pone.0015802 |
| Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral perf Psychopharmacology 2011 · 10.1007/s00213-010-2145-8 |
| Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity. Human brain mapping 2011 · 10.1002/hbm.21150 |
| The influence of emotion regulation on decision-making under risk. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2011.21618 |
| Dysfunctional reward circuitry in obsessive-compulsive disorder. Biological psychiatry 2011 · 10.1016/j.biopsych.2010.12.003 |
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| Glucose administration enhances fMRI brain activation and connectivity related to episodic memory encoding for neutral a Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.02.013 |
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| Time course and spatial distribution of fMRI signal changes during single-pulse transcranial magnetic stimulation to the NeuroImage 2011 · 10.1016/j.neuroimage.2011.03.011 |
| Neural circuitry of emotional and cognitive conflict revealed through facial expressions. PloS one 2011 · 10.1371/journal.pone.0017635 |
| How emotion leads to selective memory: neuroimaging evidence. Neuropsychologia 2011 · 10.1016/j.neuroimage.2004.05.015 |
| Investigation of the neural control of cough and cough suppression in humans using functional brain imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 · 10.1523/JNEUROSCI.4597-10.2011 |
| Common and distinct neural regions for the guidance of selection by visuoverbal information held in memory: converging e Human brain mapping 2012 · 10.1002/hbm.21196 |
| Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 · 10.1523/JNEUROSCI.3220-10.2011 |
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| Reward reduces conflict by enhancing attentional control and biasing visual cortical processing. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00011 |
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| "The human likeness dimension of the ""uncanny valley hypothesis"": behavioral and functional MRI findings." Frontiers in human neuroscience 2011 · 10.3389/fnhum.2011.00126 |
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| The neural correlates of gist-based true and false recognition. NeuroImage 2012 · 10.1016/j.neuroimage.2011.11.078 |
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| Monitoring brain activation changes in the early postoperative period after radical prostatectomy using fMRI. NeuroImage 2013 · 10.1016/j.neuroimage.2013.04.005 |
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| Testicular volume is inversely correlated with nurturing-related brain activity in human fathers. Proceedings of the National Academy of Sciences of the United States of America 2013 · 10.1073/pnas.1305579110 |
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| Where pain meets action in the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 · 10.1523/JNEUROSCI.3135-12.2013 |
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| A scaffold for efficiency in the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 · 10.1523/JNEUROSCI.1426-13.2013 |
| Existential neuroscience: self-esteem moderates neuronal responses to mortality-related stimuli. Social cognitive and affective neuroscience 2013 · 10.1093/scan/nst167 |
| Soothing the threatened brain: leveraging contact comfort with emotionally focused therapy. PloS one 2013 · 10.1371/journal.pone.0079314 |
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| Brain regions concerned with the identification of deceptive soccer moves by higher-skilled and lower-skilled players. Frontiers in human neuroscience 2013 · 10.3389/fnhum.2013.00851 |
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| Alterations in brain metabolism and function following administration of low-dose codeine phosphate:1H-magnetic resonanc PMID 27446252 |
| Imaging Imageability: Behavioral Effects and Neural Correlates of Its Interaction with Affect and Context PMID 27471455 |
| The role of language in the experience and perception of emotion: a neuroimaging meta-analysis PMID 27539864 |
| Left posterior-dorsal area 44 couples with parietal areas to promote speech fluency, while right area 44 activity promot PMID 27542724 |
| Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/o PMID 27546352 |
| A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease PMID 27565302 |
| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Charting the effects of TMS with fMRI: Modulation of cortical recruitment within the distributed network supporting sema PMID 27650816 |
| Alpha oscillation neurofeedback modulates amygdala complex connectivity and arousal in posttraumatic stress disorder PMID 27672554 |
| Effects of craving behavioral intervention on neural substrates of cue-induced craving in Internet gaming disorder PMID 27699148 |
| Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease PMID 27857211 |
| Effects of outcome on the covariance between risk level and brain activity in adolescents with internet gaming disorder PMID 27857886 |
| Motor Cortex Neurostimulation Technologies for Chronic Post-stroke Pain: Implications of Tissue Damage on Stimulation Cu PMID 27881958 |
| Sex differences in emotional perception: Meta analysis of divergent activation PMID 27988321 |
| Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of PMID 27992792 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| A variance components model for statistical inference on functional connectivity networks PMID 28130192 |
| FMRI activity during associative encoding is correlated with cardiorespiratory fitness and source memory performance in PMID 28161031 |
| Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers PMID 28161387 |
| Practice and Learning: Spatiotemporal Differences in Thalamo-Cortical-Cerebellar Networks Engagement across Learning Pha PMID 28167919 |
| Activity and connectivity of the cerebellum in trigeminal nociception PMID 28192274 |
| Flavor pleasantness processing in the ventral emotion network PMID 28207751 |
| Influence of single-dose quetiapine on fear network activity – A pharmaco-imaging study PMID 28259723 |
| Neurophysiological and BOLD signal uncoupling of giant somatosensory evoked potentials in progressive myoclonic epilepsy PMID 28294187 |
| Sliding-window analysis tracks fluctuations in amygdala functional connectivity associated with physiological arousal an PMID 28300639 |
| Long‐term white matter tract reorganization following prolonged febrile seizures PMID 28332711 |
| Corrigendum: Brain networks of perceptual decision-making: an fMRI ALE meta-analysis PMID 28337136 |
| Empathy for pain motivates actions without altruistic effects: evidence of motor dynamics and brain activity PMID 28338790 |
| Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance PMID 28344549 |
| Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis PMID 28392491 |
| Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea PMID 28392711 |
| Neural evidence for the intrinsic value of action as motivation for behavior PMID 28396007 |
| The brain anatomy of attention-deficit/hyperactivity disorder in young adults – a magnetic resonance imaging study PMID 28406942 |
| Reactivation or transformation? Motor memory consolidation associated with cerebral activation time-locked to sleep spin PMID 28422976 |
| Working Memory after Traumatic Brain Injury: The Neural Basis of Improved Performance with Methylphenidate PMID 28424597 |
| Patterns of brain and cardiovascular activation while solving rule-discovery and rule-application numeric tasks PMID 28431987 |
| Mental arithmetic in the bilingual brain: Language matters PMID 28495598 |
| Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic ciga PMID 28528203 |
| Shared and disorder-specific task-positive and default mode network dysfunctions during sustained attention in paediatri PMID 28529874 |
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| Functional brain outcomes of L2 speech learning emerge during sensorimotor transformation PMID 28669904 |
| Active avoidance and attentive freezing in the face of approaching threat PMID 28669911 |
| Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia PMID 28719572 |
| Neurofunctionally dissecting the reading system in children PMID 28780219 |
| The levels of perceptual processing and the neural correlates of increasing subjective visibility PMID 28823896 |
| Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI PMID 28826089 |
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*Brainstem · Mai atlas of record · 792 studies · 149 papers on disk*
The substantia nigra is dopamine's motor gate — the midbrain's pigmented plate between tegmentum and peduncle, its compacta's dark (neuromelanin-rich) neurons tonically licensing striatal action selection. Their loss IS Parkinson's disease: rigidity, tremor, bradykinesia.
The substantia nigra is the midbrain's pigmented plate between tegmentum and cerebral peduncle — the compacta's dark dopaminergic neurons (neuromelanin) face the peduncle, the reticulata's GABAergic sheet faces the striatum; it arches the whole midbrain length.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'midbrain, substantia nigra'}*
Dopamine's motor gate: nigrostriatal compacta neurons tonically license striatal action selection — their loss IS Parkinson's disease (rigidity, tremor, bradykinesia), while reticulata output mirrors pallidal suppression. The same neurons die in Parkinson-plus syndromes and are the substrate of dopaminergic therapy.
The functional record: nigrostriatal licensing; the reticular half's outputs shape eye movements. The decoded profile is reward, anticipation, striatum — the dopamine signal's motivational half lives here too (reward-prediction error's substrate is nigrostriatal and mesolimbic). The graded matrix carries the reward family: reward-prediction as a highly-credible stimulator, reward-punishment as stimulator and assessor — the dopaminergic forecasting literature, recorded. Its coactivation map is the midbrain row: midbrain (1,028), red nucleus (1,024+669), mammillary body (848), aqueduct (773).
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 8, Action'}*
The midbrain's tegmental row — dopamine, motor and limbic neighbours firing as one.
Co-activation partners of record: Midbrain:1028, Red nucleus:1024, Mammillary body:848, Cerebral aqueduct:773, Red nucleus:669, Substantia nigra:669, Superior colliculus:660, Amygdala:545.
Parkinson's disease: the compacta's neurons die and the striatum's gate closes — the record's stated identity. The decoded anticipation term marks the reward-prediction failure that precedes the motor ones.
10.1016/S0006-3223(99)00056-610.1093/brain/124.1.6710.1016/S0028-3932(00)00157-310.1093/cercor/11.10.95410.1016/S0896-6273(02)00603-7792 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — reward(method-other), pain(interoception), midbrain(anatomy-reference), brainstem(anatomy-reference), amygdala(anatomy-reference), nucleus(anatomy-reference), anticipation(cognition), striatum(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Midbrain:1028, Red nucleus:1024, Mammillary body:848, Cerebral aqueduct:773 — each name is a dossier stop in this explorer.