Structure. The olfactory bulb is the flattened ovoid telencephalic outgrowth riding the cribriform plate, where olfactory-nerve axons synapse in glomeruli onto mitral/tufted cells; its axons continue as the olfactory tract along the olfactory sulcus to the piriform cortex, amygdala and entorhinal area.
Function. The first relay of smell: glomerular convergence gives odour quality its map, and the tract's direct cortical projection makes olfaction the only sense that reaches cortex without a thalamic gate — smell's intimacy with memory and emotion is anatomical fact. Bulb/tract transection (shearing at the cribriform plate) is the anatomy of post-traumatic anosmia.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| igt ↗ | assessor | secondary | standard-scientific | behavioral | Region profile carries decision-risk vocabulary (choices .0057, risk .0057, gambling .0029, losses .004); on-d |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Profile term reward (.008) with the region's top term ofc (.022); on-disk fMRI gambling study finds medial/lat |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Profile pairs reward (.008) with losses (.004) and threat (.0056); on-disk fMRI monetary-incentive-delay study |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Profile is emotion-loaded (emotional .011, emotional valence .0019, bias .0025); on-disk fMRI shows parametric |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Profile carries placebo (.0034), pain (.0034) and disgust (.004); on-disk fMRI 'smell study' shows nocebo sugg |
| face-identity | assessor | secondary | standard-scientific | fMRI | Profile carries person (.0055), faces (.0023), gaze (.0015) and asd (.009); on-disk fMRI of virtual-character |
| cyberball ↗ | assessor | secondary | standard-scientific | behavioral | Region's second-ranked decoded term is social (.018) with distress (.0035) and partner (.0035); exclusion para |
| gonogo ↗ | assessor | secondary | standard-scientific | behavioral | Profile carries impulsivity (.008, rank 11) and regulation (.005); go/no-go indexes prepotent-response control |
| simple-rt ↗ | assessor | secondary | standard-scientific | behavioral | Profile carries arousal (.0047), autonomic (.004) and skin conductance (.0026) terms consistent with state/aro |
| taskswitching ↗ | stimulator | secondary | standard-scientific | delivery | On-disk reversal-learning fMRI: flexibly adapting stimulus-response associations to changed reward contingenci |
| choice-rt ↗ | stimulator | secondary | standard-scientific | delivery | Decoded profile ranks 'choices' 23rd (0.0057) with 'decision' (34), 'risk' (25), 'values' (114), 'outcome' (10 |
| stopsignal ↗ | stimulator | secondary | standard-scientific | delivery | Decoded profile ranks 'impulsivity' 11th (0.0079) with 'addiction' (116) and 'craving' (86): response-cancella |
| oddball ↗ | inhibitor | secondary | standard-scientific | delivery | Canonical suppression: repeated standards attenuate olfactory-bulb responses (adaptation/repetition suppressio |
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| The magical activation of left amygdala when reading Harry Potter: an fMRI study on how descriptions of supra-natural e PloS one 2015 · 10.1371/journal.pone.0118179 |
| Compassion-based emotion regulation up-regulates experienced positive affect and associated neural networks. Social cognitive and affective neuroscience 2015 · 10.1093/scan/nsv008 |
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| Recency, repetition, and the multidimensional basis of recognition memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 · 10.1523/JNEUROSCI.2999-14.2015 |
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| Distinct neural networks underlying empathy for pleasant and unpleasant touch. Cortex; a journal devoted to the study of the nervous system and behavior 2015 · 10.1016/j.cortex.2015.01.021 |
| Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 · 10.1523/JNEUROSCI.4182-14.2015 |
| Multiple brain networks contribute to the acquisition of bias in perceptual decision-making. Frontiers in neuroscience 2015 · 10.3389/fnins.2015.00063 |
| Studying memory encoding to promote reliable engagement of the medial temporal lobe at the single-subject level. PloS one 2015 · 10.1371/journal.pone.0119159 |
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| Brain activation in response to overt and covert fear and happy faces in women with borderline personality disorder. Brain imaging and behavior 2015 · 10.1007/s11682-015-9406-4 |
| This is your brain on Scrabble: Neural correlates of visual word recognition in competitive Scrabble players as measured Cortex; a journal devoted to the study of the nervous system and behavior 2015 · 10.1016/j.cortex.2015.03.015 |
| Brain Mechanisms for Processing Affective (and Nonaffective) Touch Are Atypical in Autism. Cerebral cortex (New York, N.Y. : 1991) 2015 · 10.1093/cercor/bhv125 |
| Verbal and nominal agreement: An fMRI study. NeuroImage 2015 · 10.1016/j.neuroimage.2015.06.075 |
| Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human brain mapping 2015 · 10.1002/hbm.22899 |
| A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal l Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00172 |
| Effects of post-extinction l-DOPA administration on the spontaneous recovery and reinstatement of fear in a human fMRI European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2015 · 10.1016/j.euroneuro.2015.07.016 |
| An fMRI investigation of the effects of culture on evaluations of stigmatized individuals. NeuroImage 2016 · 10.1016/j.neuroimage.2015.08.030 |
| Functional connectivity between the cerebrum and cerebellum in social cognition: A multi-study analysis. NeuroImage 2016 · 10.1016/j.neuroimage.2015.09.001 |
| fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. Frontiers in systems neuroscience 2015 · 10.3389/fnsys.2015.00124 |
| A task-independent neural representation of subjective certainty in visual perception. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00551 |
| Altered cerebellar-amygdala connectivity in violent offenders: A resting-state fMRI study. Neuroscience letters 2016 · 10.1016/j.neulet.2015.10.063 |
| Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00546 |
| Theory-of-mind-related neural activity for one's romantic partner predicts partner well-being. Social cognitive and affective neuroscience 2016 · 10.1093/scan/nsv144 |
| Effects of empathic social responses on the emotions of the recipient. Brain and cognition 2016 · 10.1016/j.bandc.2015.11.004 |
| Frequency-dependent alterations in regional homogeneity in major depression. Behavioural brain research 2016 · 10.1016/j.bbr.2016.03.012 |
| The neuronal correlates of mirror therapy: A functional magnetic resonance imaging study on mirror-induced visual illusi Brain research 2016 · 10.1016/j.brainres.2016.03.002 |
| Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-B PloS one 2016 · 10.1371/journal.pone.0150834 |
| Medial Prefrontal and Anterior Insular Connectivity in Early Schizophrenia and Major Depressive Disorder: A Resting Func Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00132 |
| Resting state functional connectivity of the hippocampus along the anterior-posterior axis and its association with glut Cortex; a journal devoted to the study of the nervous system and behavior 2016 · 10.1016/j.cortex.2016.03.022 |
| Outcome Uncertainty and Brain Activity Aberrance in the Insula and Anterior Cingulate Cortex Are Associated with Dysfunc Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00207 |
| Reduced Functional Connectivity within the Mesocorticolimbic System in Substance Use Disorders: An fMRI Study of Puerto Frontiers in behavioral neuroscience 2016 · 10.3389/fnbeh.2016.00102 |
| Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease. Neuropsychologia 2016 · 10.1016/j.neuropsychologia.2016.06.013 |
| Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzhei Neurobiology of aging 2016 · 10.1016/j.neurobiolaging.2016.04.010 |
| Mapping the cortical representation of speech sounds in a syllable repetition task. NeuroImage 2016 · 10.1016/j.neuroimage.2016.07.023 |
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| The Neural Development of 'Us and Them'. Social cognitive and affective neuroscience 2017 · 10.1093/scan/nsw134 |
| Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder. Brain imaging and behavior 2017 · 10.1007/s11682-016-9601-y |
| Self-similarity and recursion as default modes in human cognition. Cortex; a journal devoted to the study of the nervous system and behavior 2017 · 10.1016/j.cortex.2016.08.016 |
| Mentalizing in schizophrenia: A multivariate functional MRI study. Neuropsychologia 2016 · 10.1016/j.neuropsychologia.2016.10.013 |
| Multivariate Brain Prediction of Heart Rate and Skin Conductance Responses to Social Threat. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 · 10.1523/JNEUROSCI.3672-15.2016 |
| Distinct cortico-striatal connections with subthalamic nucleus underlie facets of compulsivity. Cortex; a journal devoted to the study of the nervous system and behavior 2017 · 10.1016/j.cortex.2016.12.018 |
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*Frontal lobe · Mai atlas of record · 291 studies · 90 papers on disk*
The olfactory bulb is the first relay of smell — a flattened ovoid riding the cribriform plate where olfactory-nerve axons converge into glomeruli, giving odour quality its map. Its tract runs straight to piriform and entorhinal targets: olfaction is the only sense that reaches cortex without a thalamic gate.
The olfactory bulb is the flattened ovoid telencephalic outgrowth riding the cribriform plate, where olfactory-nerve axons synapse in glomeruli onto mitral/tufted cells; its axons continue as the olfactory tract along the olfactory sulcus to the piriform cortex, amygdala and entorhinal area.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y +7.2…+52.2 mm, 10 plates (labels OB/olfs)'}*
The first relay of smell: glomerular convergence gives odour quality its map, and the tract's direct cortical projection makes olfaction the only sense that reaches cortex without a thalamic gate — smell's intimacy with memory and emotion is anatomical fact. Bulb/tract transection (shearing at the cribriform plate) is the anatomy of post-traumatic anosmia.
The functional record: glomerular convergence, direct cortical projection — no thalamus on the way. The decoded profile is unexpected and revealing: orbitofrontal, OFC, vmpfc, social, emotional — the olfactory literature is an orbitofrontal-flavour literature, because smell's cortical story is value and flavour. The adjacency harvest gave this dossier its literature (the bulb's papers live inside the olfactory and orbitofrontal ones); no graded instrument is assigned — the first relay's levers are the sniffs and identifications its targets perform.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 5, Sensation and Perception'}*
Straight gyrus (310 shared studies), olfactory sulcus (290), entorhinal cortex (165), amygdala (155), uncus (132) — the olfactory lane from bulb to medial temporal lobe, thalamus-free.
Co-activation partners of record: Straight gyrus:310, Olfactory sulcus:290, Entorhinal cortex:165, Amygdala:155, Uncus:132, Amygdala:129, Orbitofrontal gyri:123, Isthmus of cingulate gyrus:121.
Anosmia from bulb/tract injury (shearing at the cribriform plate — the classic frontal-trauma olfactory loss); the direct-cortex wiring explains why smell disorders carry emotional and memory weight without thalamic relay.
10.1093/cercor/12.9.90010.1152/jn.00776.200210.1016/S1053-8119(03)00103-410.1093/brain/awg21610.1016/S0896-6273(03)00392-110.1016/S0006-3223(02)01785-7291 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — ofc(anatomy-reference), social(method-other), orbitofrontal(anatomy-reference), orbitofrontal cortex(anatomy-reference), emotional(emotion), asd(social), medial(anatomy-reference), vmpfc(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Straight gyrus:310, Olfactory sulcus:290, Entorhinal cortex:165, Amygdala:155 — each name is a dossier stop in this explorer.