Structure. Brodmann area 21: middle temporal gyrus association cortex, spanning the lateral temporal lobe between STS and ITG with auditory-visual polysensory character.
Function. Lexical-semantic and multimodal integration: middle-temporal lesions (left) contribute to word-meaning access deficits; the region bridges the temporal semantic store with phonological systems above.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Risky-gamble fMRI (binary choices over monetary outcomes with explicit probabilities): the bilateral middle te |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Delivering binary risky-gamble choices (decision under risk), this fMRI showed the bilateral middle temporal g |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Affective Stroop fMRI (positive/neutral/negative images under varying cognitive load): left middle temporal gy |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | fMRI of basic facial-expression identification: the middle temporal gyrus was activated by both visual and hap |
| oddball ↗ | stimulator | secondary | standard-scientific | delivery | Region's decoded profile carries task-evoking auditory terms — 'auditory' (assoc 0.013), 'sounds' (0.005), 'he |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Event-related fMRI of risky decisions and their consequences — cautious vs risky choices gaining 5 cents or lo |
| face-identity | assessor | secondary | standard-scientific | fMRI | Whole-brain searchlight MVPA: cortical areas mostly located along the middle temporal gyrus supported identity |
| pain-induction | assessor | secondary | standard-scientific | fMRI | fMRI while low-back-pain subjects viewed a picture triggering visualization of the painful event: left middle |
| semantic-decision ↗ | assessor | secondary | standard-scientific | fMRI | Semantic relatedness judgments on visually presented word pairs (free-association strength manipulated) versus |
| sentence-comprehension | assessor | secondary | standard-scientific | fMRI | Auditory word-monitoring fMRI of spoken prose: for healthy controls, the anomalous-prose minus random-word-ord |
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| Neural Networks for Mindfulness and Emotion Suppression. PloS one 2015 · 10.1371/journal.pone.0128005 |
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| Dissociation in borderline personality disorder: Disturbed cognitive and emotional inhibition and its neural correlates. Psychiatry research 2015 · 10.1016/j.pscychresns.2015.05.018 |
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| Functionally integrated neural processing of linguistic and talker information: An event-related fMRI and ERP study. NeuroImage 2016 · 10.1016/j.neuroimage.2015.08.064 |
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| Neuroimaging of the joint Simon effect with believed biological and non-biological co-actors. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00483 |
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| Shall I compare thee: The neural basis of literary awareness, and its benefits to cognition. Cortex; a journal devoted to the study of the nervous system and behavior 2015 · 10.1016/j.cortex.2015.08.014 |
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| Distributed neural signatures of natural audiovisual speech and music in the human auditory cortex PMID 27932074 |
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| Disentangling meaning in the brain: Left temporal involvement in agreement processing PMID 27984788 |
| The neural circuits for arithmetic principles PMID 27986609 |
| Modulation of ventral striatal activity by cognitive effort PMID 27989778 |
| Relationship between resting state functional magnetic resonance imaging and memory function in mesial temporal lobe epi PMID 28017196 |
| Ipsilateral Putamen and Insula Activation by Both Left and Right GB34 Acupuncture Stimulation: An fMRI Study on Healthy PMID 28053642 |
| I know I’ve seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity PMID 28073651 |
| The role of the IFG and pSTS in syntactic prediction: Evidence from a parametric study of hierarchical structure in fMRI PMID 28088041 |
| Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach PMID 28088652 |
| Spatial Mnemonic Encoding: Theta Power Decreases and Medial Temporal Lobe BOLD Increases Co-Occur during the Usage of th PMID 28101523 |
| Different mechanisms in learning different second languages: Evidence from English speakers learning Chinese and Spanish PMID 28110086 |
| Internal and external attention and the default mode network PMID 28110087 |
| Changes in functional organization and white matter integrity in the connectome in Parkinson's disease PMID 28116232 |
| How white and black bodies are perceived depends on what emotion is expressed PMID 28128279 |
| Long-Term Experience of Chinese Calligraphic Handwriting Is Associated with Better Executive Functions and Stronger Rest PMID 28129407 |
| Isolating response inhibition in the brain: Parietal versus frontal contribution PMID 28142026 |
| Task-dependent neural and behavioral effects of verb argument structure features PMID 28160740 |
| Phonological and syntactic competition effects in spoken word recognition: evidence from corpus-based statistics PMID 28164141 |
| Practice and Learning: Spatiotemporal Differences in Thalamo-Cortical-Cerebellar Networks Engagement across Learning Pha PMID 28167919 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| Mapping visual dominance in human sleep PMID 28232191 |
| Multimodal representations of person identity individuated with fMRI PMID 28242496 |
| fMRI study of graduated emotional charge for detection of covert activity using passive listening to narratives PMID 28245989 |
| Developmental phonagnosia: Linking neural mechanisms with the behavioural phenotype PMID 28254454 |
| Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on PMID 28284787 |
| Social-cognitive brain function and connectivity during visual perspective-taking in autism and schizophrenia PMID 28291690 |
| Neurophysiological and BOLD signal uncoupling of giant somatosensory evoked potentials in progressive myoclonic epilepsy PMID 28294187 |
| Brain Activity during Mental Imagery of Gait Versus Gait-Like Plantar Stimulation: A Novel Combined Functional MRI Parad PMID 28321186 |
| Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia PMID 28348393 |
| Brain activity associated with selective attention, divided attention and distraction PMID 28363436 |
| The effect of constraining eye-contact during dynamic emotional face perception—an fMRI study PMID 28402536 |
| The Neural Basis of Speech Perception through Lipreading and Manual Cues: Evidence from Deaf Native Users of Cued Speech PMID 28424636 |
| Auditory, Visual and Audiovisual Speech Processing Streams in Superior Temporal Sulcus PMID 28439236 |
| Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder PMID 28501740 |
| Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity PMID 28545486 |
| Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with ma PMID 28559571 |
| Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms PMID 28579971 |
| Human cortical activity evoked by contextual processing in attentional orienting PMID 28592863 |
| Attempts at memory control induce dysfunctional brain activation profiles in Generalized Anxiety Disorder: An explorator PMID 28599173 |
| Neural mechanisms underlying sound-induced visual motion perception: An fMRI study PMID 28600968 |
| Neural activity during attentional conflict predicts reduction in tinnitus perception following rTMS PMID 28629874 |
| Remembering and imagining alternative versions of the personal past PMID 28633886 |
| Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study PMID 28652967 |
| The role of ventromedial prefrontal cortex volume in the association of expressive suppression and externally oriented t PMID 28688264 |
| Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Proc PMID 28690506 |
| Examining distinct working memory processes in children and adolescents using fMRI: Results and validation of a modified PMID 28704424 |
| Reading network in dyslexia: Similar, yet different PMID 28715717 |
| Neural correlates underlying the comprehension of deceitful and ironic communicative intentions PMID 28728080 |
| Functional connectivity and cognitive impairment in migraine with and without aura PMID 28730563 |
| Neural correlates of bilingual language control during interlingual homograph processing in a logogram writing system PMID 28750252 |
| Neural correlates of evaluating self and close-other in physical, academic and prosocial domains PMID 28759780 |
| The Effect of Suspense on Brain Activation and Memory During Naturalistic Viewing PMID 28764896 |
| Neurofunctionally dissecting the reading system in children PMID 28780219 |
| Does education play a role in language reorganization after surgery in drug refractory temporal lobe epilepsy: An fMRI b PMID 28802988 |
| The levels of perceptual processing and the neural correlates of increasing subjective visibility PMID 28823896 |
| Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation PMID 28827779 |
| Language for action: Motor resonance during the processing of human and robotic voices PMID 28829994 |
| Cognitive Improvement and Brain Changes after Real-Time Functional MRI Neurofeedback Training in Healthy Elderly and Pro PMID 28848488 |
| Neural congruence between intertemporal and interpersonal self-control: Evidence from delay and social discounting PMID 28877515 |
| Moral judgment modulation by disgust priming via altered fronto-temporal functional connectivity PMID 28883626 |
| The role of auditory cortex in the spatial ventriloquism aftereffect PMID 28889003 |
*Temporal lobe · Mai atlas of record · 1379 studies · 150 papers on disk*
Area 21 spans the lateral temporal lobe between the superior and inferior temporal sulci with polysensory auditory-visual character — the lexical-semantic bridge between the temporal meaning store and the phonological systems that speak it.
Brodmann area 21: middle temporal gyrus association cortex, spanning the lateral temporal lobe between STS and ITG with auditory-visual polysensory character.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 11, Language'}*
Lexical-semantic and multimodal integration: middle-temporal lesions (left) contribute to word-meaning access deficits; the region bridges the temporal semantic store with phonological systems above.
The functional record: lexical-semantic and multimodal integration — left middle-temporal lesions contribute to word-meaning access deficits, the region bridging the semantic store with phonological systems. The decoded profile is speech, language, semantic, reading. The graded matrix currently records the executive family as inhibitors (Stroop, flanker, Simon — task-positive suppression from its network-completion records); the region's own semantic grading is an open slot. Its coactivation map is the language network's spine: superior temporal sulcus (1,251 shared studies), Wernicke (1,205), opercularis (963), triangularis (876).
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 11, Language'}*
The MTG's partners read like the whole language system — comprehension, production and the multimodal bank between them.
Co-activation partners of record: Superior temporal sulcus:1251, BA 22 - Wernicke:1205, Inferior frontal gyrus, opercular part:963, Inferior frontal gyrus, triangular part:876, Planum temporale:765, Inferior frontal gyrus, orbital part:723, Superior temporal gyrus:624, Inferior frontal sulcus:593.
Word-meaning access deficits from left MTG lesions — the semantic store's bridge broken. The multimodal character (auditory-visual) marks the region's wider integration role.
10.1016/S0896-6273(00)80715-110.1016/S0896-6273(00)80759-X10.1093/cercor/9.8.8051379 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — speech(method-other), language(language), semantic(method-other), temporal(method-other), words(method-other), reading(language), auditory(perception), word(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Superior temporal sulcus:1251, BA 22 - Wernicke:1205, Inferior frontal gyrus, opercular part:963, Inferior frontal gyrus, triangular part:876 — each name is a dossier stop in this explorer.