Structure. The inferior colliculus is the caudal tectal pair — the auditory system's large midbrain integration nucleus, receiving lateral lemniscus fibres from both ears and dispatching through the brachium to the medial geniculate body.
Function. The auditory system's obligatory midbrain hub: sound localization (binaural timing/level comparisons converge here), startle-integration with the superior colliculus, and the last pre-thalamic station every auditory fibre passes — unilateral lesions leave subtle localization deficits because both ears are already represented bilaterally.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| oddball ↗ | stimulator | secondary | standard-scientific | delivery | Profile-only ground: stimuli (0.0041), responses (0.0059) and modulation (0.0046) decode beside brainstem (0.0 |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Pain is the region's strongest decoded association (0.026), with amygdala (0.009) and periaqueductal (0.007) t |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Profile-only ground: reward (0.006) and dopaminergic (0.004) decode for this region — reward and punishment ou |
| simple-rt ↗ | assessor | secondary | standard-scientific | behavioral | Profile-only ground: responses (0.0059), threat (0.0067) and fear (0.0051) decode for this region — a defensiv |
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| Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsq092 |
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| Brain regions concerned with the identification of deceptive soccer moves by higher-skilled and lower-skilled players. Frontiers in human neuroscience 2013 · 10.3389/fnhum.2013.00851 |
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| Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glut PMID 27182810 |
| Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease PMID 27301638 |
| Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor PMID 27323928 |
| Decreasing predictability of visual motion enhances feed-forward processing in visual cortex when stimuli are behavioral PMID 27334340 |
| Words in Context: The Effects of Length, Frequency, and Predictability on Brain Responses During Natural Reading PMID 27365297 |
| Exploring the Neural Representation of Novel Words Learned through Enactment in a Word Recognition Task PMID 27445918 |
| Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accide PMID 27547195 |
| Episodic specificity induction impacts activity in a core brain network during construction of imagined future experienc PMID 27601666 |
| Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation PMID 27622387 |
| Charting the effects of TMS with fMRI: Modulation of cortical recruitment within the distributed network supporting sema PMID 27650816 |
| Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-on PMID 27668175 |
| Alpha oscillation neurofeedback modulates amygdala complex connectivity and arousal in posttraumatic stress disorder PMID 27672554 |
| Mentalizing in schizophrenia: A multivariate functional MRI study PMID 27793657 |
| Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder PMID 27842291 |
| Comparative Multimodal Meta-analysis of Structural and Functional Brain Abnormalities in Autism Spectrum Disorder and Ob PMID 27887721 |
| A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia PMID 27895619 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| Lost emotion: Disrupted brain-based tracking of dynamic affective episodes in anxiety and depression PMID 28013067 |
| Predicting the Multisensory Consequences of One’s Own Action: BOLD Suppression in Auditory and Visual Cortices PMID 28060861 |
| Distinct cortico-striatal connections with subthalamic nucleus underlie facets of compulsivity PMID 28103527 |
| Changes in functional organization and white matter integrity in the connectome in Parkinson's disease PMID 28116232 |
| FMRI activity during associative encoding is correlated with cardiorespiratory fitness and source memory performance in PMID 28161031 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| Grey matter alterations in migraine: A systematic review and meta-analysis PMID 28180071 |
| Activity and connectivity of the cerebellum in trigeminal nociception PMID 28192274 |
| A direct comparison of appetitive and aversive anticipation: Overlapping and distinct neural activation PMID 28267576 |
| Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizop PMID 28289394 |
| Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity PMID 28322310 |
| Long‐term white matter tract reorganization following prolonged febrile seizures PMID 28332711 |
| Functional Brain Activation in Response to a Clinical Vestibular Test Correlates with Balance PMID 28344549 |
| Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis PMID 28392491 |
| Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea PMID 28392711 |
| Neural evidence for the intrinsic value of action as motivation for behavior PMID 28396007 |
| Patterns of brain and cardiovascular activation while solving rule-discovery and rule-application numeric tasks PMID 28431987 |
| Kinematics in the brain: unmasking motor control strategies? PMID 28573311 |
| Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study PMID 28626785 |
| Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems PMID 28654776 |
| Active avoidance and attentive freezing in the face of approaching threat PMID 28669911 |
| Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia PMID 28719572 |
| Dissonance encoding in human inferior colliculus covaries with individual differences in dislike of dissonant music PMID 28720776 |
| Adolescent Major Depressive Disorder: Neuroimaging Evidence of Sex Difference during an Affective Go/No-Go Task PMID 28744228 |
| The Effect of Suspense on Brain Activation and Memory During Naturalistic Viewing PMID 28764896 |
| Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI PMID 28826089 |
| Investigating the Neural Correlates of Emotion–Cognition Interaction Using an Affective Stroop Task PMID 28919871 |
*Brainstem · Mai atlas of record · 527 studies · 152 papers on disk*
The inferior colliculus is the auditory system's obligatory midbrain hub — every lateral lemniscus fiber from both ears converges here before the brachium dispatches sound to the thalamus. It is also the startle-reflex's integration point with the superior colliculus: sound and flinch, wired together.
The inferior colliculus is the caudal tectal pair — the auditory system's large midbrain integration nucleus, receiving lateral lemniscus fibres from both ears and dispatching through the brachium to the medial geniculate body.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'midbrain, tectum'}*
The auditory system's obligatory midbrain hub: sound localization (binaural timing/level comparisons converge here), startle-integration with the superior colliculus, and the last pre-thalamic station every auditory fibre passes — unilateral lesions leave subtle localization deficits because both ears are already represented bilaterally.
The functional record: binaural timing and level comparisons converge for sound localization; startle integrates; the last pre-thalamic relay completes. Its decoded profile is the midbrain's row — pain, threat, periaqueductal, amygdala — the colliculus sits inside the defensive circuitry, not just hearing. No graded instrument is assigned; the audition family's levers live on the cortex this hub feeds.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 5, Sensation and Perception'}*
Superior colliculus (734 shared studies), midbrain (602), cerebral aqueduct (460), substantia nigra (454), pons (378) — the midbrain's tectal and motor row.
Co-activation partners of record: Superior colliculus:734, Midbrain:602, Cerebral aqueduct:460, Substantia nigra:454, Pons:378, Substantia nigra:378, Red nucleus:359, Thalamus:307.
Auditory brainstem responses die at this hub in brainstem lesions; the startle circuit's failure (hyperekplexia's opposite) marks its integration role. The hub's clinical story is conduction, not cognition.
10.1093/brain/124.1.6710.1093/brain/124.2.39910.1016/S0926-6410(00)00056-210.1016/S0896-6273(01)00328-210.1016/S0896-6273(01)00583-9527 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — pain(interoception), brainstem(anatomy-reference), midbrain(anatomy-reference), amygdala(anatomy-reference), cerebellar(anatomy-reference), threat(method-other), periaqueductal(anatomy-reference), reward(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Superior colliculus:734, Midbrain:602, Cerebral aqueduct:460, Substantia nigra:454 — each name is a dossier stop in this explorer.