Structure. Brodmann areas 23/31: posterior cingulate cortex beneath the precuneus around the splenium — granular retrosplenial-adjacent belt of the posteromedial cortex.
Function. The default mode's metabolic maximum: self-referential and episodic retrieval traffic, hippocampal-cortical consolidation dialogue, and the earliest-hypometabolic cortical zone in Alzheimer's disease.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stroop ↗ | inhibitor | secondary | highly-credible | delivery | Task-induced deactivation of posterior cingulate default cortex during demanding performance. |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Gambling-task fMRI (20 volunteers choosing small likely rewards vs large unlikely rewards) placed posterior ci |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | fMRI assessed BOLD during the gambling task: the activation table reports a posterior cingulate peak (-4,-38,3 |
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| Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirme PMID 28188881 |
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| Hierarchical control of procedural and declarative category-learning systems PMID 28213114 |
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| fMRI study of graduated emotional charge for detection of covert activity using passive listening to narratives PMID 28245989 |
| Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with c PMID 28257930 |
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| Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife PMID 28413778 |
| Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report PMID 28446211 |
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| Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms PMID 28579971 |
| Cannabis-induced alterations in brain activation during a test of information processing speed in patients with MS PMID 28607694 |
| Remembering and imagining alternative versions of the personal past PMID 28633886 |
| Illuminating the conceptual structure of the space of moral violations with searchlight representational similarity anal PMID 28743459 |
| Neural correlates of evaluating self and close-other in physical, academic and prosocial domains PMID 28759780 |
| Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset sch PMID 28793242 |
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| Neural correlates of working memory in children and adolescents with agenesis of the corpus callosum: An fMRI study PMID 28893526 |
*Limbic lobe & medial ring · Mai atlas of record · 966 studies · 150 papers on disk*
The posterior cingulate is the default mode's metabolic maximum — the busiest resting cortex in the brain, and ironically the earliest zone to go hypometabolic in Alzheimer's disease. The region that works hardest when you do nothing is the first to fail.
Brodmann areas 23/31: posterior cingulate cortex beneath the precuneus around the splenium — granular retrosplenial-adjacent belt of the posteromedial cortex.
*— {'source': 'Raichle, MacLeod, Snyder, Powers, Gusnard & Shulman', 'work': 'A default mode of brain function, Proc Natl Acad Sci U S A 2001', 'locator': 'midline areas within the posterior cingulate and precuneus', 'kind': 'paper'}*
The default mode's metabolic maximum: self-referential and episodic retrieval traffic, hippocampal-cortical consolidation dialogue, and the earliest-hypometabolic cortical zone in Alzheimer's disease.
The functional record: self-referential and episodic retrieval traffic, the hippocampal-cortical consolidation dialogue. The decoded profile is network, memory, default, episodic — this is the posteromedial core's hub. The graded matrix records the task-relation honestly: the Stroop as a highly-credible inhibitor (task-positive performance suppresses this resting giant — task-induced deactivation, the seed's own physiology), emotional-Stroop as stimulator and assessor.
*— {'source': 'Raichle, MacLeod, Snyder, Powers, Gusnard & Shulman', 'work': 'A default mode of brain function, Proc Natl Acad Sci U S A 2001', 'locator': 'posterior cingulate as a principal default-mode node', 'kind': 'paper'}*
Anterior cingulate (396 shared studies), isthmus (396), angular gyrus (388), intraparietal sulcus (370) — the default network's medial-lateral triangle, precisely as Raichle drew it.
Co-activation partners of record: Cingulate gyrus, anterior:396, Isthmus of cingulate gyrus:396, Angular gyrus:388, Intraparietal sulcus:370, Paracingulate gyrus:365, Thalamus:340, Inferior frontal gyrus, opercular part:310, Collateral sulcus:307.
Alzheimer's earliest hypometabolism; the deactivation failure in task states. Its Stroop-inhibitor record is the atlas's cleanest example of a region defined by what it does when you stop.
10.1016/S0920-9964(98)00141-810.1016/S0926-6410(99)00029-410.1016/S0028-3932(99)00098-6966 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — network(anatomy-reference), memory(cognition), default(cognition), posterior cingulate(anatomy-reference), dmn(anatomy-reference), cingulate(anatomy-reference), episodic(cognition), connectivity(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Cingulate gyrus, anterior:396, Isthmus of cingulate gyrus:396, Angular gyrus:388, Intraparietal sulcus:370 — each name is a dossier stop in this explorer.