Structure. The subcallosal gyrus (parolfactory area, area 25's subgenual territory) sits below the rostrum of the corpus callosum between the anterior commissure and the optic chiasm region, medial to the olfactory sulcus' posterior end.
Function. The subgenual cingulate — mood regulation's cortical choke point: its activity marks depression states and responds to deep-brain stimulation for treatment-resistant depression; it couples limbic affect with autonomic and motivational outflow.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Delivering appetitive vs aversive food tastes and pictures during fMRI, subgenual anterior cingulate cortex em |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Gaussian-process-classifier fMRI in 25 healthy adults decoded taste condition at 73-86.5% accuracy (p=0.001), |
Experiences of record: Evening wind-down protocol
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| Correlated structural and functional brain abnormalities in the default mode network in schizophrenia patients. Schizophrenia research 2011 · 10.1016/j.schres.2010.10.027 |
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| Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2010.12.015 |
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| In vivo evidence of global and focal brain alterations in anorexia nervosa. Psychiatry research 2011 · 10.1016/j.pscychresns.2010.12.008 |
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| Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes. Psychiatry research 2011 · 10.1016/j.pscychresns.2011.01.005 |
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| How one's favorite song activates the reward circuitry of the brain: personality matters! Behavioural brain research 2011 · 10.1016/j.bbr.2011.08.012 |
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| Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology 2012 · 10.1007/s00213-011-2543-6 |
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| Alterations of the salience network in obesity: a resting-state fMRI study. Human brain mapping 2013 · 10.1002/hbm.22104 |
| Serotonin selectively modulates reward value in human decision-making. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 · 10.1523/JNEUROSCI.0053-12.2012 |
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| Impaired comprehension of temporal connectives in Parkinson's disease--a neuroimaging study. Neuropsychologia 2012 · 10.1016/j.neuropsychologia.2012.04.004 |
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| High versus low level of response to alcohol: evidence of differential reactivity to emotional stimuli. Biological psychiatry 2012 · 10.1016/j.biopsych.2012.04.016 |
| From animal model to human brain networking: dynamic causal modeling of motivational systems. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 · 10.1523/JNEUROSCI.6188-11.2012 |
| The amygdala is involved in affective priming effect for fearful faces. Brain and cognition 2012 · 10.1016/j.bandc.2012.04.005 |
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| Is race erased? Decoding race from patterns of neural activity when skin color is not diagnostic of group boundaries. Social cognitive and affective neuroscience 2013 · 10.1093/scan/nss063 |
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| Nucleus accumbens response to rewards and testosterone levels are related to alcohol use in adolescents and young adults PMID 26771250 |
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| Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents PMID 26830347 |
| Decreased Fronto-Limbic Activation and Disrupted Semantic-Cued List Learning in Major Depressive Disorder PMID 26831638 |
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| Fusiform gyrus laterality in writing systems with different mapping principles: An artificial orthography training study PMID 26918586 |
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| Cough Is Dangerous: Neural Correlates of Implicit Body Symptoms Associations PMID 26973558 |
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| Supersize my brain: A cross-sectional voxel-based morphometry study on the association between self-reported dietary res PMID 26995784 |
| Neural underpinnings of divergent production of rules in numerical analogical reasoning PMID 27016127 |
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| A study of the brain functional network of Deqi via acupuncturing stimulation at BL40 by rs-fMRI PMID 27062952 |
| Increased frequency of social interaction is associated with enjoyment enhancement and reward system activation PMID 27090501 |
| Effects of serotonin 2A/1A receptor stimulation on social exclusion processing PMID 27091970 |
| Non-symbolic and symbolic notations in simple arithmetic differentially involve intraparietal sulcus and angular gyrus a PMID 27117869 |
| fMRI study of neural sensitization to hedonic stimuli in long‐term, daily cannabis users PMID 27168331 |
| Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glut PMID 27182810 |
| Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder PMID 27187232 |
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*Temporal lobe · Mai atlas of record · 842 studies · 91 papers on disk*
The subcallosal gyrus (the parolfactory area, area 25's territory) sits below the callosal rostrum between the anterior commissure and the optic chiasm — mood regulation's cortical choke point: its activity marks depression states, and deep-brain stimulation here treats treatment-resistant depression.
The subcallosal gyrus (parolfactory area, area 25's subgenual territory) sits below the rostrum of the corpus callosum between the anterior commissure and the optic chiasm region, medial to the olfactory sulcus' posterior end.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y −28.0…+17.1 mm, 12 plates (labels scg)'}*
The subgenual cingulate — mood regulation's cortical choke point: its activity marks depression states and responds to deep-brain stimulation for treatment-resistant depression; it couples limbic affect with autonomic and motivational outflow.
The functional record: the subgenual cingulate — mood regulation's choke point. The decoded profile is reward, striatum, ventral striatum, anticipation — the ventral reward-mood circuit's hub. The graded matrix carries the emotional family: emotional-Stroop as stimulator and assessor, facial-emotion as stimulator — standard-scientific records on a region whose DBS story is among psychiatry's most significant.
*— {'source': 'Josephine C. Moore', 'work': 'Brain Atlas and Functional Systems', 'kind': 'atlas', 'locator': 'limbic system, functional systems'}*
BA 25 subgenual cingulate (921 shared studies), amygdala (445+405), paraterminal gyrus (406), uncus (368) — the subgenual reward-mood row, firing as one medial wall.
Co-activation partners of record: BA 25 - subgenual cingulate:921, Amygdala:445, Paraterminal gyrus:406, Amygdala:405, Uncus:368, Entorhinal cortex:337, Rhinal sulcus:331, Caudate nucleus:284.
Treatment-resistant depression's hyperactivity; DBS's remissions. The subcallosal dossier is the atlas's psychiatric-surgery page — small (91 studies), and among the most consequential.
The 91-study dossier is small for its consequence — the subcallosal zone earned its DBS chapter through a decade of Mayberg's targeting work, and its decoded reward-anticipation terms mark the ventral striatum's reach into the mood wall. Its 90-paper neighbour (paraterminal) shares the row: the medial reward-mood line is thin, dense and surgical.
10.1093/cercor/11.1.5910.1093/cercor/11.1.7310.1073/pnas.07104309810.1046/j.0953-816x.2001.01589.x10.1093/cercor/12.3.318842 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — reward(method-other), striatum(method-other), ventral striatum(method-other), cingulate(anatomy-reference), ventral(method-other), anticipation(cognition), feedback(cognition), self(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
BA 25 - subgenual cingulate:921, Amygdala:445, Paraterminal gyrus:406, Amygdala:405 — each name is a dossier stop in this explorer.