Structure. The external segment of the globus pallidus is the lentiform complex's pale medial companion plate, split from the internal segment by the medial medullary lamina; it is the indirect pathway's central relay, linked to the subthalamic nucleus by the subthalamic fascicle.
Function. The brake-amplifier of action selection: GABAergic pallidosubthalamic inhibition lets the subthalamic nucleus excite output nuclei — the indirect path's tonic-suppression loop. Its disinhibition (lesion or stimulation) quiets the ballism/dystonic overflow that loss of subthalamic control produces.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| pain-induction | assessor | secondary | standard-scientific | fMRI | Watching a confederate receive noxious shock engaged the pain matrix: the pain localizer lists left pallidum i |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | In an fMRI reinforcement-learning task, the model letting stimulus discriminability adjust reward prediction f |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | 81 adolescents chose between a cautious option (1 cent certain) and a risky one (win 5 / lose 10 cents, odds f |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | In a valenced-picture distraction paradigm, MDD patients showed reduced activation in only the positive task a |
| gonogo ↗ | assessor | secondary | standard-scientific | fMRI | The region's own decoded profile holds 'inhibition' (0.005) and 'response' (0.004) among its top terms, and it |
| nback ↗ | stimulator | secondary | standard-scientific | delivery | Visuospatial working-memory fMRI: healthy controls activated the right putamen and medial globus pallidus besi |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Thatcher-illusion face task (attend eyes vs mouth, upright vs inverted): neurotypical controls showed right-he |
| stopsignal ↗ | stimulator | secondary | standard-scientific | delivery | Profile ground: the region's decoded associations carry inhibition (0.005) and response (0.004) - the initiate |
| simple-rt ↗ | stimulator | secondary | standard-scientific | delivery | Profile ground: motor (0.013), movements (0.008) and response (0.004) top the region's own associations - the |
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| Distinct brain networks for time-varied characteristics of acupuncture. Neuroscience letters 2010 · 10.1016/j.neulet.2009.11.031 |
| Using perfusion MRI to measure the dynamic changes in neural activation associated with tonic muscular pain. Pain 2010 · 10.1016/j.pain.2009.10.003 |
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| Prestimulus functional connectivity determines pain perception in humans. Proceedings of the National Academy of Sciences of the United States of America 2010 · 10.1073/pnas.0906186106 |
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| Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease. NeuroImage 2010 · 10.1016/j.neuroimage.2009.11.046 |
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| Behavioral, neuroimaging, and computational evidence for perceptual caching in repetition priming. Brain research 2010 · 10.1016/j.brainres.2009.11.074 |
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| Acupuncture needling sensation: the neural correlates of deqi using fMRI. Brain research 2010 · 10.1016/j.brainres.2009.12.019 |
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| The contribution of mesiofrontal cortex to the preparation and execution of repetitive syllable productions: an fMRI stu NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.039 |
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| Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ). NeuroImage 2011 · 10.1016/j.neuroimage.2011.01.052 |
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| fMRI evidence of a relationship between hypomania and both increased goal-sensitivity and positive outcome-expectancy bi Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.06.008 |
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| A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induce NeuroImage 2012 · 10.1016/j.neuroimage.2011.10.099 |
| Neural events leading to and associated with detection of sounds under high processing load. Human brain mapping 2013 · 10.1002/hbm.21457 |
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| What do you feel? Adolescent drug and alcohol users show altered brain response to pleasant interoceptive stimuli. Drug and alcohol dependence 2013 · 10.1016/j.drugalcdep.2013.08.015 |
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| Existential neuroscience: effects of mortality salience on the neurocognitive processing of attractive opposite-sex face Social cognitive and affective neuroscience 2013 · 10.1093/scan/nst157 |
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| Differential reward network functional connectivity in cannabis dependent and non-dependent users. Drug and alcohol dependence 2014 · 10.1016/j.drugalcdep.2014.04.002 |
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| The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes. Cerebral cortex (New York, N.Y. : 1991) 2014 · 10.1093/cercor/bhu159 |
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| Neural substrates of child irritability in typically developing and psychiatric populations. Developmental cognitive neuroscience 2015 · 10.1016/j.dcn.2015.07.003 |
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| Working Memory after Traumatic Brain Injury: The Neural Basis of Improved Performance with Methylphenidate. Frontiers in behavioral neuroscience 2017 · 10.3389/fnbeh.2017.00058 |
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| Influence of the cortical midline structures on moral emotion and motivation in moral decision-making PMID 26772629 |
| Efficacy of identifying neural components in the face and emotion processing system in schizophrenia using a dynamic fun PMID 26792586 |
| The activation of interactive attentional networks PMID 26794640 |
| A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play PMID 26802508 |
| Stimulus-dependent amygdala involvement in affective theory of mind generation PMID 26803059 |
| Effects of empathic social responses on the emotions of the recipient PMID 26812250 |
| Computational substrates of social norm enforcement by unaffected third parties PMID 26825438 |
| Fear and Reward Circuit Alterations in Pediatric CRPS PMID 26834606 |
| The Brain Mechanisms Underlying the Perception of Pungent Taste of Capsaicin and the Subsequent Autonomic Responses PMID 26834613 |
| Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-sta PMID 26837944 |
| Seasonality in human cognitive brain responses PMID 26858432 |
| Language comprehension and brain function in individuals with an optimal outcome from autism PMID 26862477 |
| Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depressi PMID 26869950 |
| ALE meta‐analysis reveals dissociable networks for affective and discriminative aspects of touch PMID 26873519 |
| Voluntary control of anterior insula and its functional connections is feedback-independent and increases pain empathy PMID 26899786 |
| Dynamic neural mechanisms underlie race disparities in social cognition PMID 26908320 |
| Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease PMID 26935551 |
| Frequency-dependent alterations in regional homogeneity in major depression PMID 26968135 |
| Differences in the central-nervous processing of olfactory stimuli according to their hedonic and arousal characteristic PMID 26968764 |
| Functional Magnetic Resonance Imaging Study of Brain Activity Associated With Pitch Adaptation During Phonation in Healt PMID 27049447 |
| Functional connectivity of the left and right hippocampi: Evidence for functional lateralization along the long-axis usi PMID 27132046 |
| fMRI study of neural sensitization to hedonic stimuli in long‐term, daily cannabis users PMID 27168331 |
| Cortisol alters reward processing in the human brain PMID 27170428 |
| Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder PMID 27187232 |
| Task and Resting-State fMRI Reveal Altered Salience Responses to Positive Stimuli in Patients with Major Depressive Diso PMID 27192082 |
| The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture PMID 27230218 |
| Working memory contributes to the encoding of object location associations: Support for a 3-part model of object locatio PMID 27233825 |
| "Association between striatal dopamine D2/D3receptors and PMID 27244237 |
| Neural mechanisms of goal-contingent task disengagement: Response-irrelevant stimuli activate the default mode network PMID 27253724 |
| Effects of progressive muscle relaxation on cerebral activity: An fMRI investigation PMID 27261979 |
| Does the sound of a barking dog activate its corresponding visual form? An fMRI investigation of modality-specific seman PMID 27289210 |
| Interaction between episodic and semantic memory networks in the acquisition and consolidation of novel spoken words PMID 27291335 |
| Brain Bases of Working Memory for Time Intervals in Rhythmic Sequences PMID 27313506 |
| Effects of aging on task- and stimulus-related cerebral attention networks PMID 27318136 |
| Regional homogeneity changes in amnestic mild cognitive impairment patients PMID 27345927 |
| Neural substrates of successful working memory and long-term memory formation in a relational spatial memory task PMID 27350001 |
| Patterns of regional gray matter loss at different stages of schizophrenia: A multisite, cross-sectional VBM study in fi PMID 27354958 |
| Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-anal PMID 27397863 |
| Neural effects of methylphenidate and nicotine during smooth pursuit eye movements PMID 27402599 |
| Health and Pleasure in Consumers' Dietary Food Choices: Individual Differences in the Brain's Value System PMID 27428267 |
| The Neural Substrates Underlying the Implementation of Phonological Rule in Lexical Tone Production: An fMRI Study of th PMID 27455078 |
| Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adole PMID 27459031 |
| Imaging Imageability: Behavioral Effects and Neural Correlates of Its Interaction with Affect and Context PMID 27471455 |
| Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in neg PMID 27474908 |
| Relationship between Parental Feeding Practices and Neural Responses to Food Cues in Adolescents PMID 27479051 |
| Altered Vision-Related Resting-State Activity in Pituitary Adenoma Patients with Visual Damage PMID 27512990 |
| Neural signatures of experience-based improvements in deterministic decision-making PMID 27523644 |
| A Neural Basis for the Acquired Capability for Suicide PMID 27531983 |
| Decreased Activation of Subcortical Brain Areas in the Motor Fatigue State: An fMRI Study PMID 27536264 |
| The role of language in the experience and perception of emotion: a neuroimaging meta-analysis PMID 27539864 |
| Left posterior-dorsal area 44 couples with parietal areas to promote speech fluency, while right area 44 activity promot PMID 27542724 |
| A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease PMID 27565302 |
| Structural and Functional MRI Differences in Master Sommeliers: A Pilot Study on Expertise in the Brain PMID 27597821 |
| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Cognitive and neural consequences of memory suppression in major depressive disorder PMID 27649971 |
| Functional abnormalities of the right posterior insula are related to the altered self-experience in schizophrenia PMID 27662482 |
| Increased anticipatory but decreased consummatory brain responses to food in sisters of anorexia nervosa patients PMID 27703784 |
| Cerebral Activity Associated with Transient Sleep-Facilitated Reduction in Motor Memory Vulnerability to Interference PMID 27725727 |
| Brain Activity in Patients With Adductor Spasmodic Dysphonia Detected by Functional Magnetic Resonance Imaging PMID 27746043 |
| High Frequency Migraine Is Associated with Lower Acute Pain Sensitivity and Abnormal Insula Activity Related to Migraine PMID 27746728 |
| A neural mechanism of cognitive control for resolving conflict between abstract task rules PMID 27771559 |
| Abnormal resting-state functional connectivity study in unilateral pulsatile tinnitus patients with single etiology: A s PMID 27776655 |
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| Adolescent neural response to reward is related to participant sex and task motivation PMID 27816780 |
| Early grey matter changes in structural covariance networks in Huntington's disease PMID 27830113 |
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| Patterns of neural activity predict picture-naming performance of a patient with chronic aphasia PMID 27864027 |
| Functional and Structural Signatures of the Anterior Insula are associated with Risk-taking Tendency of Analgesic Decisi PMID 27892543 |
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| Decreased amygdala functional connectivity in adolescents with autism: A resting-state fMRI study PMID 27969061 |
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| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
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| Changes in the correlation between spatial and temporal source memory performance and BOLD activity across the adult lif PMID 28190516 |
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| Neural underpinnings of prosexual effects induced by gamma-hydroxybutyrate in healthy male humans PMID 28284776 |
| Altered functional connectivity in brain networks underlying self-referential processing in delusions of reference in sc PMID 28315577 |
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*Frontal lobe · Mai atlas of record · 1054 studies · 134 papers on disk*
The right external pallidum — the mirror brake. Same pale plate, same GABAergic pallidosubthalamic loop, same clinical shadow: when these neurons degenerate, chorea is the visible result of a lifted brake.
The external segment of the globus pallidus is the lentiform complex's pale medial companion plate, split from the internal segment by the medial medullary lamina; it is the indirect pathway's central relay, linked to the subthalamic nucleus by the subthalamic fascicle.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'basal ganglia, internal structure'}*
The brake-amplifier of action selection: GABAergic pallidosubthalamic inhibition lets the subthalamic nucleus excite output nuclei — the indirect path's tonic-suppression loop. Its disinhibition (lesion or stimulation) quiets the ballism/dystonic overflow that loss of subthalamic control produces.
The functional record mirrors the left's: the indirect pathway's tonic suppression amplified through the subthalamic nucleus. The right's decoded profile adds reward to the motor vocabulary — the pallidum's ventral reach into motivational selection. No graded instrument is assigned; the direct/indirect balance is measured through the behavioural batteries the caudate's dossier records.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 8, Action'}*
Putamen (1,111 shared studies), the mirror pallidum (815+814), thalamus (772), claustrum (760) — the lentiform complex's internal conversation.
Co-activation partners of record: Putamen:1111, Globus pallidus, external segment:815, Putamen:814, Thalamus:772, Claustrum:760, Thalamus:752, Supplementary motor area:640, Claustrum:636.
Chorea again — hemiballismus's wilder cousin when the subthalamic nucleus itself fails on this side. The brake metaphor is the clinic's: lift it and movement escapes.
The right pallidum's reward term earns its place: the ventral pallidum's extension into motivational circuitry makes this plate a junction between movement braking and wanting — the same GABAergic loop, gated one level up. Its 134 studies track the stereotaxy literature too: the pallidum is a deep-brain-stimulation target, and the right plate's coordinates are charted in the movement-disorder atlases.
10.1016/S0896-6273(00)80715-110.1016/S0006-3223(99)00083-910.1093/brain/122.10.19891054 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — motor(action-motor), pain(interoception), putamen(anatomy-reference), reward(method-other), movements(action-motor), basal(anatomy-reference), basal ganglia(anatomy-reference), ganglia(anatomy-reference) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Putamen:1111, Globus pallidus, external segment:815, Putamen:814, Thalamus:772 — each name is a dossier stop in this explorer.