Structure. Brodmann area 11: orbitofrontal granulo-dysgranular cortex of the frontal lobe's orbital surface, within the olfactory-sulcus-bounded medial orbital complex; dense amygdala, insular and taste/visceral connectivity.
Function. Reward value and reversal: secondary-taste/odour value coding, rapid reversal when contingencies flip, and the somatic-marker modulation of decisions — its damage leaves IQ intact and judgement impaired.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Task-fMRI of spontaneous empathic response to short videos of facial expressions of pain: left orbitofrontal c |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Same fMRI paradigm: viewing facial expressions of pain in others evoked left orbitofrontal cortex activation ( |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Profile-only ground: the region's decoded Neurosynth association holds task-evoking terms 'emotional' (0.0057) |
| igt ↗ | assessor | secondary | standard-scientific | behavioral | bvFTD/AD/controls: IGT scored inside the VMPFC task composite; that composite correlated with orbitofrontal-co |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Left OFC BOLD under PAIN>NO-PAIN indexes perceived pain in others; activation levels comparable between ASD an |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Parametric fMRI with computer-generated neutral-expression faces: OFC BOLD scaled linearly with rated facial a |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Monetary gain/lose feedback contingencies (main effect of contingency, factorial ANOVA): left orbitofrontal co |
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| Brain activation during neurocognitive testing using functional near-infrared spectroscopy in patients following concuss PMID 24477579 |
| Contrasting Prefrontal Cortex Contributions to Episodic Memory Dysfunction in Behavioural Variant Frontotemporal Dementi PMID 24505314 |
| The anterior temporal lobes support residual comprehension in Wernicke’s aphasia PMID 24519979 |
| Neuroprotective effects of testosterone treatment in men with multiple sclerosis PMID 24634831 |
| Impulsivity, aggression and brain structure in high and low lethality suicide attempters with borderline personality dis PMID 24656768 |
| Contradictory Reasoning Network: An EEG and fMRI Study PMID 24667491 |
| Topological organization of the “small-world” visual attention network in children with attention deficit/hyperactivity PMID 24688465 |
| Task-Induced Brain Activity Patterns in Type 2 Diabetes: A Potential Biomarker for Cognitive Decline PMID 24705405 |
| Reduced self-referential neural response during intergroup competition predicts competitor harm PMID 24726338 |
| The impact of age on prefrontal cortex integrity during spatial working memory retrieval PMID 24825744 |
| Brain mediators of the effects of noxious heat on pain PMID 24845572 |
| Greater amygdala activity and dorsomedial prefrontal–amygdala coupling are associated with enhanced inflammatory respons PMID 25016200 |
| Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state network PMID 25035300 |
| Lateralized task shift effects in Broca's and Wernicke's regions and in visual word form area are selective for conceptu PMID 25047449 |
| Buffering Social Influence: Neural Correlates of Response Inhibition Predict Driving Safety in the Presence of a Peer PMID 25100217 |
| Effects of reward contingencies on brain activation during feedback processing PMID 25206327 |
| Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia PMID 25239737 |
| Visual gravity cues in the interpretation of biological movements: neural correlates in humans PMID 25315789 |
| Ability to Maintain Internal Arousal and Motivation Modulates Brain Responses to Emotions PMID 25438046 |
| Functional Connectivity Mapping of Regions Associated with Self- and Other-Processing PMID 25482016 |
| Neural activity associated with self, other, and object-based counterfactual thinking PMID 25579447 |
| Getting on the same page: The neural basis for social coordination deficits in behavioral variant frontotemporal degener PMID 25619850 |
| Decrease in gamma-band activity tracks sequence learning PMID 25653598 |
| Morphological derivation overflow as a result of disruption of the left frontal aslant white matter tract PMID 25658634 |
| Gender Effects in Alcohol Dependence: An fMRI Pilot Study Examining Affective Processing PMID 25684049 |
| Compassion-based emotion regulation up-regulates experienced positive affect and associated neural networks PMID 25698699 |
| Adolescent heavy drinkers' amplified brain responses to alcohol cues decrease over one month of abstinence PMID 25796007 |
| The smelling of Hedione results in sex-differentiated human brain activity PMID 25797832 |
| Frequency-Dependent Changes of Local Resting Oscillations in Sleep-Deprived Brain PMID 25798918 |
| Interhemispheric Functional and Structural Disconnection in Alzheimer’s Disease: A Combined Resting-State fMRI and DTI S PMID 25938561 |
| Thirst and the state-dependent representation of incentive stimulus value in human motive circuitry PMID 25971601 |
| Regional gray matter density is associated with morningness–eveningness: Evidence from voxel-based morphometry PMID 26003859 |
| Filling in the gaps: Anticipatory control of eye movements in chronic mild traumatic brain injury PMID 26106545 |
| The significance of caudate volume for age-related associative memory decline PMID 26119913 |
| Response control networks are selectively modulated by attention to rare events and memory load regardless of the need f PMID 26190403 |
| Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study PMID 26208746 |
| Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks PMID 26266268 |
| Effect of Simulated Microgravity on Human Brain Gray Matter and White Matter – Evidence from MRI PMID 26270525 |
| Framing effects reveal discrete lexical-semantic and sublexical procedures in reading: an fMRI study PMID 26441712 |
| Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T PMID 26550990 |
| Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA PMID 26673947 |
| Decreased functional connectivity density in pain-related brain regions of female migraine patients without aura PMID 26688226 |
| Enhancing Motor Network Activity Using Real-Time Functional MRI Neurofeedback of Left Premotor Cortex PMID 26733832 |
| Cortical thickness changes in patients with Parkinson's disease and impulse control disorders PMID 26810913 |
| Decreased sleep duration is associated with increased fMRI responses to emotional faces in children PMID 26821063 |
| The Simpson's paradox and fMRI: Similarities and differences between functional connectivity measures derived from withi PMID 27101735 |
| Resting-state fMRI reveals potential neural correlates of impaired cognition in Huntington's disease PMID 27117563 |
| The Effect of Depo Medroxyprogesterone Acetate (DMPA) on Cerebral Food Motivation Centers: A Pilot Study using Functiona PMID 27129935 |
| The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture PMID 27230218 |
| Characterizing cerebellar activity during autobiographical memory retrieval: ALE and functional connectivity investigati PMID 27235570 |
| Dissociating patterns of anterior and posterior hippocampal activity and connectivity during distinct forms of category PMID 27343687 |
| An individual differences analysis of the neurocognitive architecture of the semantic system at rest PMID 27662589 |
| Cognitive Slowing in Gulf War Illness Predicts Executive Network Hyperconnectivity: Study in a Population-Representative PMID 27672557 |
| Dominant hemisphere functional networks compensate for structural connectivity loss to preserve phonological retrieval w PMID 27688934 |
| Bilateral parietal contributions to spatial language PMID 27690125 |
| Brain responses to facial attractiveness induced by facial proportions: evidence from an fMRI study PMID 27779211 |
| The neural bases of proactive and reactive control processes in normal aging PMID 27784627 |
| Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain PMID 27841974 |
| Filtering and storage working memory networks in younger and older age PMID 27843697 |
| Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease PMID 27857211 |
| Multivariate Brain Prediction of Heart Rate and Skin Conductance Responses to Social Threat PMID 27881783 |
| Neural Basis of Working Memory Enhancement after Acute Aerobic Exercise: fMRI Study of Preadolescent Children PMID 27917141 |
| Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasonin PMID 27979789 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| Adaptive Adolescent Flexibility: Neurodevelopment of Decision-making and Learning in a Risky Context PMID 28129057 |
| Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in an adult lifespan sam PMID 28138504 |
| Neurophysiological and BOLD signal uncoupling of giant somatosensory evoked potentials in progressive myoclonic epilepsy PMID 28294187 |
| A neural network underlying intentional emotional facial expression in neurodegenerative disease PMID 28373956 |
| Duration of motherhood has incremental effects on mothers’ neural processing of infant vocal cues: a neuroimaging study PMID 28496095 |
| Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with ma PMID 28559571 |
| Patterns of activation and de-activation associated with cue-guided spatial navigation: A whole-brain, voxel-based study PMID 28663090 |
| Reading network in dyslexia: Similar, yet different PMID 28715717 |
| Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset sch PMID 28793242 |
| The levels of perceptual processing and the neural correlates of increasing subjective visibility PMID 28823896 |
| Lexical-Semantic Search Under Different Covert Verbal Fluency Tasks: An fMRI Study PMID 28848407 |
*Frontal lobe · Mai atlas of record · 204 studies · 139 papers on disk*
The orbitofrontal cortex is where value lives — the second taste, the wine's bouquet, the reversal you notice when a reward stops rewarding. Its functional record carries the famous dissociation: damage here leaves IQ intact and judgement impaired.
Brodmann area 11: orbitofrontal granulo-dysgranular cortex of the frontal lobe's orbital surface, within the olfactory-sulcus-bounded medial orbital complex; dense amygdala, insular and taste/visceral connectivity.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 10, Emotion'}*
Reward value and reversal: secondary-taste/odour value coding, rapid reversal when contingencies flip, and the somatic-marker modulation of decisions — its damage leaves IQ intact and judgement impaired.
Secondary taste and odour value coding, rapid reversal learning when contingencies flip, and somatic-marker modulation of decisions — this is BA 11's decoded profile too: olfactory and value vocabulary dominate. The graded matrix currently records the executive family (Stroop, flanker, Simon) as inhibitors — value regions quiet down during response conflict — and with only 204 studies in its dossier, this is one of the atlas's thinner majors: a frontier for the harvest to come.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 10, Emotion'}*
Its coactivation map is small and self-referential in a telling way: the mirror orbitofrontal gyri (261), then entorhinal cortex, orbital and opercular inferior frontal, amygdala and uncus — the value-and-smell ring, exactly the circuit reversal learning needs.
Co-activation partners of record: Orbitofrontal gyri:261, Entorhinal cortex:83, Inferior frontal gyrus, orbital part:82, Inferior frontal gyrus, opercular part:81, Amygdala:77, Uncus:75, Middle temporal gyrus:73, Olfactory sulcus:71.
The record's phrasing is surgical: IQ intact, judgement impaired — the somatic-marker patient who can describe every option and cannot choose. Reversal-learning failures and altered olfactory-affective judgement complete the picture.
10.1093/brain/awf09310.1016/S0166-4328(02)00187-010.1136/jnnp.73.6.66510.1016/S1053-8119(02)00041-110.1016/S0896-6273(03)00095-3204 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — ofc(anatomy-reference), orbitofrontal(anatomy-reference), orbitofrontal cortex(anatomy-reference), olfactory(perception), matter(anatomy-reference), gray matter(anatomy-reference), adults(method-other), semantic(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Orbitofrontal gyri:261, Entorhinal cortex:83, Inferior frontal gyrus, orbital part:82, Inferior frontal gyrus, opercular part:81 — each name is a dossier stop in this explorer.