Structure. The hippocampus is the sea-horse-shaped allocortical structure folded into the medial temporal lobe beneath the parahippocampal gyrus: the dentate gyrus, the Cornu Ammonis fields (CA3, CA2, CA1) and subiculum, rolling ventrally as the hippocampus' body, tail and alveus-fimbria efferent sheet. Its trisynaptic circuit runs entorhinal cortex → dentate → CA3 → CA1 → subiculum → back to entorhinal.
Function. Declarative memory's encoder: rapid binding of episodes into cortically stored traces (the patient H.M. — bilateral medial temporal resection — could not form new conscious memories), spatial mapping through place cells, and pattern separation/completion via dentate-CA3 dynamics. Theta rhythms organize its traffic (Buzsáki's two-stage memory program: encoding during theta, replay-consolidation during sharp-wave ripples in sleep).
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
Experiences of record: Paired-associates memory builder
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| Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: an fMRI study of panic disorder Psychiatry research 2010 · 10.1016/j.pscychresns.2010.06.005 |
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| Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2010.12.015 |
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| Taking Sides with Pain - Lateralization aspects Related to Cerebral Processing of Dental Pain. Frontiers in human neuroscience 2011 · 10.3389/fnhum.2011.00012 |
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| Frontal-medial temporal interactions mediate transitions among representational states in short-term memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 · 10.1523/JNEUROSCI.0130-14.2014 |
| The effects of acute stress exposure on striatal activity during Pavlovian conditioning with monetary gains and losses. Frontiers in behavioral neuroscience 2014 · 10.3389/fnbeh.2014.00179 |
| Impact of puberty on the evolution of cerebral perfusion during adolescence. Proceedings of the National Academy of Sciences of the United States of America 2014 · 10.1073/pnas.1400178111 |
| Effects of long-term acupuncture treatment on resting-state brain activity in migraine patients: a randomized controlled PloS one 2014 · 10.1371/journal.pone.0099538 |
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| Altered cognition-related brain activity and interactions with acute pain in migraine. NeuroImage. Clinical 2015 · 10.1016/j.nicl.2015.01.003 |
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| Changes in gray matter volume after microsurgical lumbar discectomy: a longitudinal analysis. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00012 |
| Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measu Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00074 |
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| Autobiographical deficits correlate with gray matter volume in depressed and high risk participants. Social cognitive and affective neuroscience 2015 · 10.1093/scan/nsv047 |
| Symptom severity and disgust-related traits in borderline personality disorder: The role of amygdala subdivisions. Psychiatry research 2015 · 10.1016/j.pscychresns.2015.04.002 |
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| Interhemispheric microstructural connectivity in bitemporal lobe epilepsy with hippocampal sclerosis. Cortex; a journal devoted to the study of the nervous system and behavior 2015 · 10.1016/j.cortex.2015.03.018 |
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| Co-activated yet disconnected-Neural correlates of eye closures when trying to stay awake. NeuroImage 2015 · 10.1016/j.neuroimage.2015.03.085 |
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| GABA Concentrations in the Anterior Cingulate Cortex Are Associated with Fear Network Function and Fear Recovery in Huma PMID 28496404 |
| Molecular imaging of serotonin degeneration in mild cognitive impairment PMID 28511918 |
| Complex regional pain syndrome: The matter of white matter? PMID 28523214 |
| Anatomical Modularity of Verbal Working Memory? Functional Anatomical Evidence from a Famous Patient with Short-Term Mem PMID 28567009 |
| Kinematics in the brain: unmasking motor control strategies? PMID 28573311 |
| Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms PMID 28579971 |
| Brain activity related to working memory for temporal order and object information PMID 28602963 |
| Remembering and imagining alternative versions of the personal past PMID 28633886 |
| Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems PMID 28654776 |
| Functional and structural changes in gray matter of parkinson's disease patients with mild cognitive impairment PMID 28668411 |
| Alteration of cortico-limbic-striatal neural system in major depressive disorder and bipolar disorder PMID 28668591 |
| Investigating the Blood Oxygenation Level-Dependent Functional MRI Response to a Verbal Fluency Task in Early Stroke bef PMID 28674515 |
| Neural and behavioural correlates of autobiographical memory retrieval in patients with major depressive disorder and a PMID 28697998 |
| Examining distinct working memory processes in children and adolescents using fMRI: Results and validation of a modified PMID 28704424 |
| Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia PMID 28719572 |
| Single‐trialEEG‐informedfMRIanalysis of emotional decision problems in hot executive function PMID 28729935 |
| Effective connectivity during successful and unsuccessful recollection in young and old adults PMID 28733247 |
| Neural differences underlying face processing in veterans with TBI and co-occurring TBI and PTSD PMID 28753471 |
| Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults PMID 28756237 |
| Neural correlates of evaluating self and close-other in physical, academic and prosocial domains PMID 28759780 |
| Hippocampal activation and memory performance in schizophrenia depend on strategy use in a virtual maze PMID 28780430 |
| General and emotion-specific alterations to cognitive control in women with a history of childhood abuse PMID 28794976 |
| d-Cycloserine facilitates extinction learning and enhances extinction-related brain activation PMID 28807795 |
| Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI study PMID 28860463 |
| Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces PMID 28877512 |
| Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration PMID 28882633 |
*Limbic lobe & medial ring · Mai atlas of record · 1182 studies · 171 papers on disk*
The hippocampus is declarative memory's encoder — the sea-horse-shaped allocortex folded into the medial temporal lobe, where episodes are rapidly bound into cortical traces. The patient H.M., bilaterally resected, could not form a new conscious memory; everything else about him stayed intact. That dissociation is this region's entire job description.
The hippocampus is the sea-horse-shaped allocortical structure folded into the medial temporal lobe beneath the parahippocampal gyrus: the dentate gyrus, the Cornu Ammonis fields (CA3, CA2, CA1) and subiculum, rolling ventrally as the hippocampus' body, tail and alveus-fimbria efferent sheet. Its trisynaptic circuit runs entorhinal cortex → dentate → CA3 → CA1 → subiculum → back to entorhinal.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 9, Memory'}*
Declarative memory's encoder: rapid binding of episodes into cortically stored traces (the patient H.M. — bilateral medial temporal resection — could not form new conscious memories), spatial mapping through place cells, and pattern separation/completion via dentate-CA3 dynamics. Theta rhythms organize its traffic (Buzsáki's two-stage memory program: encoding during theta, replay-consolidation during sharp-wave ripples in sleep).
The functional record adds the second specialty: spatial mapping — place cells firing the brain's inner GPS. The decoded profile is the memory system's own: encoding, retrieval, episodic, hippocampal — plus the amygdala's emotional coloring at the border. The graded matrix carries the emotional family (emotional-Stroop as stimulator and assessor, facial-emotion as stimulator) — the hippocampus tags emotional context, its dialogue with the amygdala recorded in 1,100 shared studies.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 9, Memory'}*
*— {'source': 'György Buzsáki', 'work': 'Rhythms of the Brain, Oxford University Press, 2006', 'kind': 'textbook', 'locator': 'hippocampal theta and sharp-wave ripples'}*
Hippocampal fissure (1,689 shared studies), parahippocampal gyrus (1,362), amygdala (1,100), collateral sulcus (1,030), entorhinal cortex (1,018) — the gate, the encoder and the corridor, co-activating as one memory organ.
Co-activation partners of record: Hippocampal fissure:1689, Parahippocampal gyrus:1362, Amygdala:1100, Collateral sulcus:1030, Entorhinal cortex:1018, Amygdala:874, Hippocampus:866, Uncus:777.
H.M. is the failure-mode of record: anterograde amnesia, the past preserved, the future unrecordable. Spatial memory's loss (London taxi drivers' posterior growth inverted) and tau's march complete the clinical picture.
10.1016/S0896-6273(00)80715-110.1093/brain/122.5.94310.1093/cercor/9.8.80510.1046/j.1460-9568.2000.00064.x1182 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — memory(cognition), hippocampus(anatomy-reference), hippocampal(anatomy-reference), encoding(cognition), retrieval(method-other), episodic(cognition), amygdala(anatomy-reference), mtl(anatomy-reference) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Hippocampal fissure:1689, Parahippocampal gyrus:1362, Amygdala:1100, Collateral sulcus:1030 — each name is a dossier stop in this explorer.