Structure. Brodmann area 25: subgenual cingulate cortex beneath the genu's rostrum — a small autonomic-visceral limen zone with dense hypothalamic and brainstem projections.
Function. Depression's subgenual hub: metabolic hyperactivity marks treatment-resistant depression, and deep-brain stimulation at area 25 produces remission in a subset — the smallest cortex with a psychiatric neurosurgical target.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Gambling-task fMRI of unexpected monetary gains vs losses engaged a fronto-striatal-limbic network (main peaks |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Affective decision-making under risk probed by fMRI 'risky gains' task (cash out vs double-or-nothing gamble): |
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| Where pain meets action in the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 · 10.1523/JNEUROSCI.3135-12.2013 |
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| Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measu Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00074 |
| Mothers know best: redirecting adolescent reward sensitivity toward safe behavior during risk taking. Social cognitive and affective neuroscience 2015 · 10.1093/scan/nsv026 |
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| Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients PMID 28180070 |
| Neural patterns underlying the effect of negative distractors on working memory in older adults PMID 28242539 |
| From the Cover: A neural model of valuation and information virality PMID 28242678 |
| High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil PMID 28254457 |
| Depression alters maternal extended amygdala response and functional connectivity during distress signals in attachment PMID 28263829 |
| Neural underpinnings of prosexual effects induced by gamma-hydroxybutyrate in healthy male humans PMID 28284776 |
| Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizop PMID 28289394 |
| Imagining the future: The core episodic simulation network dissociates as a function of timecourse and the amount of sim PMID 28324695 |
| Enhancing Effects of NMDA-Receptor Blockade on Extinction Learning and Related Brain Activation Are Modulated by BMI PMID 28326025 |
| Not in one metric: Neuroticism modulates different resting state metrics within distinctive brain regions PMID 28342970 |
| Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation m PMID 28413706 |
| The neural correlates of theory of mind and their role during empathy and the game of chess: A functional magnetic reson PMID 28495332 |
| Unreliability of putative fMRI biomarkers during emotional face processing PMID 28506872 |
| Behavioural and neural evidence for the impact of fluency context on conscious memory PMID 28544942 |
| Avoidant Responses to Interpersonal Provocation Are Associated with Increased Amygdala and Decreased Mentalizing Network PMID 28660251 |
| Noradrenergic modulation of neural erotic stimulus perception PMID 28683981 |
| Remembering verbally-presented items as pictures: Brain activity underlying visual mental images in schizophrenia patien PMID 28746902 |
| Neural correlates of evaluating self and close-other in physical, academic and prosocial domains PMID 28759780 |
| General and emotion-specific alterations to cognitive control in women with a history of childhood abuse PMID 28794976 |
| Age-Related Shift in Neuro-Activation during a Word-Matching Task PMID 28848422 |
*Temporal lobe · Mai atlas of record · 750 studies · 151 papers on disk*
The smallest cortex with a psychiatric neurosurgical target. Area 25 — subgenual cingulate, beneath the genu's rostrum — is a thumb-sized autonomic-visceral zone whose metabolic overactivity marks treatment-resistant depression, and whose deep-brain stimulation produces remission in a subset of patients who had nothing left to try.
Brodmann area 25: subgenual cingulate cortex beneath the genu's rostrum — a small autonomic-visceral limen zone with dense hypothalamic and brainstem projections.
*— {'source': 'Josephine C. Moore', 'work': 'Brain Atlas and Functional Systems', 'kind': 'atlas', 'locator': 'limbic system, functional systems'}*
Depression's subgenual hub: metabolic hyperactivity marks treatment-resistant depression, and deep-brain stimulation at area 25 produces remission in a subset — the smallest cortex with a psychiatric neurosurgical target.
The functional record is that sentence, and it is extraordinary. The decoded profile adds the affective-reward context: reward, striatum, ventral striatum, anticipation, feedback — the subgenual zone couples emotional forecasting to visceral output through dense hypothalamic and brainstem projections. The graded matrix carries the emotional-Stroop family: stimulator and assessor records, with facial-emotion as a standard stimulator.
*— {'source': 'Josephine C. Moore', 'work': 'Brain Atlas and Functional Systems', 'kind': 'atlas', 'locator': 'limbic system, functional systems'}*
Its coactivation map is tight and limbic: subcallosal gyrus (1,001 shared studies), paraterminal gyrus (549), amygdala (377), anterior cingulate (355) — the medial mood wall, firing as one structure.
Co-activation partners of record: Subcallosal gyrus:1001, Paraterminal gyrus:549, Amygdala:377, Cingulate gyrus, anterior:355, Amygdala:352, Third ventricle:303, Caudate nucleus:295, Uncus:289.
Hyperactivity = treatment-resistant depression; DBS at area 25 = remission in a subset. Both claims are the record's own. The honest frontier: with a small study base in its dossier, this region's depth lies ahead of its bibliography.
10.1093/cercor/10.11.107810.1093/cercor/10.11.109310.1093/cercor/11.1.5910.1093/cercor/11.1.73750 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — reward(method-other), striatum(method-other), cingulate(anatomy-reference), ventral striatum(method-other), social(method-other), anterior cingulate(anatomy-reference), caudate(anatomy-reference), pictures(perception) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Subcallosal gyrus:1001, Paraterminal gyrus:549, Amygdala:377, Cingulate gyrus, anterior:355 — each name is a dossier stop in this explorer.