Structure. The central sulcus (of Rolando) runs obliquely from the interhemispheric margin (its upper end lies behind the midpoint of the frontal lobe) down toward the Sylvian fissure, separating the precentral (motor) from the postcentral (sensory) gyrus — the frontal–parietal boundary of record.
Function. The brain's single most important surface landmark: the hand knob ('omega sign') within it marks the hand motor area; it is the border between the somatomotor network's frontal (execution) and parietal (sensory) banks.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| mental-rotation ↗ | assessor | secondary | standard-scientific | fMRI | Mental rotation of the hand and motor imagery both drive bilateral premotor/SMA BOLD around the central-sulcus |
| nback ↗ | assessor | secondary | standard-scientific | fMRI | ALE meta-analysis of M1 activation in higher cognition finds left Area 4a engaged by working-memory contrasts |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | In a modified Stroop with pain-related vs positive/neutral words, chronic musculoskeletal pain patients showed |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Nociceptive and somatosensory processing engages primary/secondary somatosensory cortex on the region's postce |
| simple-rt ↗ | assessor | secondary | standard-scientific | behavioral | Response speed indexes the hand-knob motor area within ce-l that executes every speeded response; motor is the |
| choice-rt ↗ | assessor | secondary | standard-scientific | behavioral | Preparing and executing a choice response recruits the sensorimotor bank around the central sulcus; the region |
| simple-rt ↗ | stimulator | secondary | standard-scientific | delivery | An imperative stimulus demanding a maximal-speed response is the canonical driver of the hand-knob motor bank |
| gonogo ↗ | stimulator | secondary | standard-scientific | delivery | The go-heavy stream keeps the prepotent response machinery loaded: every go trial ends in a speeded key-press |
| taskswitching ↗ | stimulator | secondary | standard-scientific | delivery | In the on-disk event-related set-shifting fMRI, response-selection events showed group-differential activation |
| oddball ↗ | stimulator | secondary | standard-scientific | delivery | Table 1 of the on-disk EEG-fMRI study lists regions activated during P300-BCI target-detection operations: lef |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Whole-brain analysis of the positive-vs-negative reinforcement-valence contrast found a group difference in le |
| tactile-adaptation | inhibitor | secondary | standard-scientific | delivery | Sustained pressure to the right index fingertip drove exponentially decreasing BOLD over 15 s in contralateral |
| repetition-priming ↗ | inhibitor | secondary | standard-scientific | delivery | Repeating environmental sounds (identical or semantically related exemplars) suppressed BOLD in left postcentr |
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| Attention inhibition of early cortical activation to fearful faces. Brain research 2010 · 10.1016/j.brainres.2009.11.060 |
| Exploring the brain in pain: activations, deactivations and their relation. Pain 2010 · 10.1016/j.pain.2009.11.008 |
| The neural basis of agency: an fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.054 |
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| Neural correlates of episodic retrieval: an fMRI study of the part-list cueing effect. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.114 |
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| Increased neural activation during picture encoding and retrieval in 60-year-olds compared to 20-year-olds. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.04.011 |
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| What differs in visual recognition of handwritten vs. printed letters? An fMRI study. Human brain mapping 2011 · 10.1002/hbm.21105 |
| Dopaminergic modulation of the default mode network in Parkinson's disease. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010 · 10.1016/j.euroneuro.2010.07.001 |
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| The involvement of occipital and inferior frontal cortex in the phonological learning of Chinese characters. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21571 |
| Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task. Proceedings of the National Academy of Sciences of the United States of America 2010 · 10.1073/pnas.1011455107 |
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| Adolescent resting state networks and their associations with schizotypal trait expression. Frontiers in systems neuroscience 2010 · 10.3389/fnsys.2010.00035 |
| A new method based on ICBM152 head surface for probe placement in multichannel fNIRS. NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.030 |
| Post-error behavioral adjustments are facilitated by activation and suppression of task-relevant and task-irrelevant inf The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3274-10.2010 |
| The embodiment of emotional feelings in the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.1725-10.2010 |
| The neural correlates of negative prediction error signaling in human fear conditioning. NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.042 |
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| Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Frontiers in systems neuroscience 2010 · 10.3389/fnsys.2010.00041 |
| Is 2+2=4? Meta-analyses of brain areas needed for numbers and calculations. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.009 |
| Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes. The European journal of neuroscience 2010 · 10.1111/j.1460-9568.2010.07424.x |
| Intention processing in communication: a common brain network for language and gestures. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21594 |
| Effect of attention on cortical processing of sound motion: an EEG study. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.031 |
| Linking inter-individual differences in neural activation and behavior to intrinsic brain dynamics. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.046 |
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| Effects of alcohol on brain responses to social signals of threat in humans. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.062 |
| Encoding strategy accounts for individual differences in change detection measures of VSTM. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2010.11.034 |
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| Neural correlates of language comprehension in autism spectrum disorders: when language conflicts with world knowledge. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.01.018 |
| Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity. Human brain mapping 2011 · 10.1002/hbm.21150 |
| Conduction aphasia, sensory-motor integration, and phonological short-term memory - an aggregate analysis of lesion and Brain and language 2011 · 10.1016/j.bandl.2010.12.001 |
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| Neural bases of language switching in high and early proficient bilinguals. Brain and language 2011 · 10.1016/j.bandl.2011.03.011 |
| The effects of attention on age-related relational memory deficits: fMRI evidence from a novel attentional manipulation. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00058 |
| Functional imaging reveals working memory and attention interact to produce the attentional blink. Journal of cognitive neuroscience 2012 · 10.1162/jocn_a_00054 |
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| Neural circuitry underlying affective response to peer feedback in adolescence. Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsr043 |
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| How does the brain regulate negative bias to stigma? Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsr046 |
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| Sleep deprivation alters valuation signals in the ventromedial prefrontal cortex. Frontiers in behavioral neuroscience 2011 · 10.3389/fnbeh.2011.00070 |
| Dissociation of brain areas associated with force production and stabilization during manipulation of unstable objects. Experimental brain research 2011 · 10.1007/s00221-011-2903-9 |
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| Mapping Depression in Schizophrenia: A Functional Magnetic Resonance Imaging Study PMID 26712855 |
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| Graph-theoretical analysis of resting-state fMRI in pediatric obsessive–compulsive disorder PMID 26773910 |
| It's Sad but I Like It: The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons PMID 26778996 |
| Evaluating cognitive models of visual word recognition using fMRI: Effects of lexical and sublexical variables PMID 26806289 |
| Converging effects of cocaine addiction and sex on neural responses to monetary rewards PMID 26809268 |
| Brain-based decoding of mentally imagined film clips and sounds reveals experience-based information patterns in film pr PMID 26826515 |
| Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched PMID 26833066 |
| Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to mot PMID 26842987 |
| Distinct medial temporal networks encode surprise during motivation by reward versus punishment PMID 26854903 |
| Language comprehension and brain function in individuals with an optimal outcome from autism PMID 26862477 |
| Age-related changes in overcoming proactive interference in associative memory: The role of PFC-mediated executive contr PMID 26879623 |
| Differential Resting State Connectivity Patterns and Impaired Semantically Cued List Learning Test Performance in Early PMID 26888619 |
| Mental imagery of speech implicates two mechanisms of perceptual reactivation PMID 26889603 |
| How do negative emotions impair self-control? A neural model of negative urgency PMID 26892861 |
| Voluntary control of anterior insula and its functional connections is feedback-independent and increases pain empathy PMID 26899786 |
| Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in sc PMID 26904405 |
| Somatotopic Semantic Priming and Prediction in the Motor System PMID 26908635 |
| Hurt but still alive: Residual activity in the parahippocampal cortex conditions the recognition of familiar places in a PMID 26909331 |
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| Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers PMID 26990646 |
| Direction-dependent activation of the insular cortex during vertical and horizontal hand movements PMID 27001175 |
| Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning PMID 27014154 |
| Modulating rest-break length induces differential recruitment of automatic and controlled attentional processes upon tas PMID 27039697 |
| Functional Magnetic Resonance Imaging Study of Brain Activity Associated With Pitch Adaptation During Phonation in Healt PMID 27049447 |
| Dyslexic brain activation abnormalities in deep and shallow orthographies: A meta‐analysis of 28 functional neuroimaging PMID 27061464 |
| Neural representations of novel objects associated with olfactory experience PMID 27083305 |
| Auditory motion in the sighted and blind: Early visual deprivation triggers a large-scale imbalance between auditory and PMID 27107468 |
| Relationship between grey matter integrity and executive abilities in aging PMID 27107940 |
| Neural activity related to discrimination and vocal production of consonant and dissonant musical intervals PMID 27134038 |
| Dysfunction of the cingulo-opercular network in first-episode medication-naive patients with major depressive disorder PMID 27155070 |
| Cortisol alters reward processing in the human brain PMID 27170428 |
| Athlete or athletic? Limited differential brain activation in person descriptions using nouns or adjectives PMID 27172859 |
| Conditional Granger Causality Analysis of Effective Connectivity during Motor Imagery and Motor Execution in Stroke Pati PMID 27200373 |
| The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture PMID 27230218 |
| Characterizing cerebellar activity during autobiographical memory retrieval: ALE and functional connectivity investigati PMID 27235570 |
| Altered Brain Network in Amyotrophic Lateral Sclerosis: A Resting Graph Theory-Based Network Study at Voxel-Wise Level PMID 27242409 |
| Stereoscopically Observing Manipulative Actions PMID 27252350 |
| Neural Processing of Emotional Musical and Nonmusical Stimuli in Depression PMID 27284693 |
| Brain activation profiles during kinesthetic and visual imagery: An fMRI study PMID 27288703 |
| Inter-hemispheric plasticity in patients with median nerve injury PMID 27291455 |
| Spontaneous pupil dilations during the resting state are associated with activation of the salience network PMID 27291493 |
| Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor PMID 27323928 |
| Neurobiological substrates of cognitive rigidity and autonomic inflexibility in generalized anxiety disorder PMID 27345596 |
| The Cognitive Side of M1 PMID 27378891 |
| Elevated Amygdala Perfusion Mediates Developmental Sex Differences in Trait Anxiety PMID 27395327 |
| Neural effects of methylphenidate and nicotine during smooth pursuit eye movements PMID 27402599 |
| Mapping the cortical representation of speech sounds in a syllable repetition task PMID 27421186 |
| Exploring the anatomical encoding of voice with a mathematical model of the vocal system PMID 27436593 |
| The transition from childhood to adolescence is marked by a general decrease in amygdala reactivity and an affect-specif PMID 27445112 |
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| Increased Brain Activation for Dual Tasking with 70-Days Head-Down Bed Rest PMID 27601982 |
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| Brain Responses during the Anticipation of Dyspnea PMID 27648309 |
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| Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting- PMID 28116563 |
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| Activation of writing-specific brain regions when reading Chinese as a second language. Effects of training modality and PMID 28131811 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| How people with multiple sclerosis cope with a sustained finger motor task: A behavioural and fMRI study PMID 28188814 |
| Functional connectivity of motor cortical network in patients with brachial plexus avulsion injury after contralateral c PMID 28236051 |
| Disrupted neural activity patterns to novelty and effort in young adult APOE‐e4 carriers performing a subsequent memory PMID 28239522 |
| Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD PMID 28279623 |
| Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on PMID 28284787 |
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| Real‐time fMRIneurofeedback in adolescents with attention deficit hyperactivity disorder PMID 28342214 |
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| Neural Correlates of Semantic Prediction and Resolution in Sentence Processing PMID 28411271 |
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*Frontal lobe · Mai atlas of record · 1097 studies · 178 papers on disk*
The sulcus of Rolando is the brain's most important surface landmark — the oblique frontier between the brain's deciding and doing halves, with the hand knob's omega sign marking the hand's motor territory inside it.
The central sulcus (of Rolando) runs obliquely from the interhemispheric margin (its upper end lies behind the midpoint of the frontal lobe) down toward the Sylvian fissure, separating the precentral (motor) from the postcentral (sensory) gyrus — the frontal–parietal boundary of record.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y −50.7…+10.1 mm, 30 plates (labels cs/ce)'}*
The brain's single most important surface landmark: the hand knob ('omega sign') within it marks the hand motor area; it is the border between the somatomotor network's frontal (execution) and parietal (sensory) banks.
The functional record: the border between the somatomotor network's frontal (execution) and parietal (sensory) banks; the omega sign localizes the hand motor area without opening the skull. The decoded profile is motor, movement, hand — with language and speech production terms appearing because this sulcus also bounds the inferior frontal operculum below. No graded instrument is assigned — the sulcus is a landmark whose banks carry the graded records (M1, S1).
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 8, Action'}*
Precentral gyrus (1,206 shared studies), supplementary motor area (753), premotor (665), anterior cingulate (659), postcentral gyrus (578) — both banks, firing as the sensorimotor system.
Co-activation partners of record: Precentral gyrus:1206, Supplementary motor area:753, BA 6 - premotor/SMA:665, Cingulate gyrus, anterior:659, Postcentral gyrus:578, Intraparietal sulcus:572, Postcentral sulcus:548, Lateral fissure:542.
The sulcus itself fails only as a boundary: its banks' lesions produce the motor and sensory syndromes recorded on their own dossiers. The landmark's failure-mode is surgical misidentification — which the omega sign prevents.
10.1016/S0926-6410(98)00055-X10.1016/S0920-9964(98)00141-81097 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — motor(action-motor), speech(method-other), movement(action-motor), premotor(anatomy-reference), movements(action-motor), language(language), hand(action-motor), production(language) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Precentral gyrus:1206, Supplementary motor area:753, BA 6 - premotor/SMA:665, Cingulate gyrus, anterior:659 — each name is a dossier stop in this explorer.