Structure. The orbitofrontal gyri form the inferior (orbital) surface of the frontal lobe, an H-shaped or zigzag complex of gyri framed by the olfactory sulcus medially and the orbital sulcus, above the orbit. Cytologically granular dysgranular areas 11/13/47; heavily connected with amygdala, insula and taste/visceral afferents.
Function. Value computation: encoding reward and punishment magnitude, reversing learned stimulus–reward associations, and decision-making flavoured by emotion. Famous sequelae of bilateral damage (classically orbitofrontal) are disinhibition, social-ethical lapses and reversal-learning failure with otherwise normal IQ.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| facial-emotion | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Modified ANT flanker fMRI (incongruent flanking arrows): the left IFG/OFC (MNI -28, 30, -16; p=.01, k=146) app |
| reward-punishment ↗ | inhibitor | secondary | standard-scientific | delivery | Emotional-intensity judgment of pictures: negative vs neutral valence deactivated left orbitofrontal gyrus (pe |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Verbal short-term memory probe-recognition (2/4/6-letter lists): left OFC deactivated load-dependently during |
| igt ↗ | inhibitor | secondary | standard-scientific | delivery | Balloon Analogue Risk Task in adolescents: risky choices made after punishment feedback (explosion) decreased |
| reward-prediction ↗ | inhibitor | secondary | standard-scientific | delivery | Monetary Incentive Delay in cannabis users: loss anticipation attenuated left frontal-pole/orbitofrontal respo |
Experiences of record: Balloon risk calibration
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| An acute psychosocial stress enhances the neural response to smoking cues. Brain research 2009 · 10.1016/j.brainres.2009.07.048 |
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| "Neural systems of social comparison and the ""above-average"" effect." NeuroImage 2010 · 10.1016/j.neuroimage.2009.10.075 |
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| Face processing changes in normal aging revealed by fMRI adaptation. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00026 |
| Is morality unified? Evidence that distinct neural systems underlie moral judgments of harm, dishonesty, and disgust. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00017 |
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| The effects of attention on age-related relational memory deficits: fMRI evidence from a novel attentional manipulation. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00058 |
| Differential neural activity during search of specific and general autobiographical memories elicited by musical cues. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.04.032 |
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| Neuroimaging self-esteem: a fMRI study of individual differences in women. Social cognitive and affective neuroscience 2013 · 10.1093/scan/nss032 |
| Counterfactual thinking: an fMRI study on changing the past for a better future. Social cognitive and affective neuroscience 2013 · 10.1093/scan/nss031 |
| Gray matter network associated with risk for Alzheimer's disease in young to middle-aged adults. Neurobiology of aging 2012 · 10.1016/S1053-8119(00)91734-8 |
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| Visual gravity cues in the interpretation of biological movements: Neural correlates in humans. NeuroImage 2014 · 10.1016/j.neuroimage.2014.10.006 |
| Large-scale brain network dynamics supporting adolescent cognitive control. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 · 10.1523/JNEUROSCI.1634-14.2014 |
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| Many ways to read your vowels--Neural processing of diacritics and vowel letters in Hebrew. NeuroImage 2015 · 10.1016/j.neuroimage.2015.07.029 |
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| Electrical Neuroimaging of Music Processing Reveals Mid-Latency Changes with Level of Musical Expertise. Frontiers in neuroscience 2017 · 10.3389/fnins.2017.00613 |
| Age-Related Brain Activation Changes during Rule Repetition in Word-Matching. Frontiers in human neuroscience 2017 · 10.3389/fnhum.2017.00543 |
| The neural signature of self-concept development in adolescence: The role of domain and valence distinctions. Developmental cognitive neuroscience 2018 · 10.1016/j.dcn.2017.11.005 |
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| The auditory cortex hosts network nodes influential for emotion processing: An fMRI study on music-evoked fear and joy. PloS one 2018 · 10.1371/journal.pone.0190057 |
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| Neurophysiological Effects of Trait Empathy in Music Listening. Frontiers in behavioral neuroscience 2018 · 10.3389/fnbeh.2018.00066 |
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| Autistic empathy toward autistic others PMID 25332405 |
| Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome PMID 25379449 |
| Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding PMID 25424131 |
| Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness PMID 25432022 |
| Ability to Maintain Internal Arousal and Motivation Modulates Brain Responses to Emotions PMID 25438046 |
| Decreased functional connectivity in an executive control network is related to impaired executive function in Internet PMID 25445475 |
| Functional Connectivity Mapping of Regions Associated with Self- and Other-Processing PMID 25482016 |
| Altered spontaneous neuronal activity in chronic posttraumatic stress disorder patients before and after a 12-week parox PMID 25527996 |
| Effect of Integrated Cognitive Therapy on Hippocampal Functional Connectivity Patterns in Stroke Patients with Cognitive PMID 25548595 |
| Neural dissociation of food- and money-related reward processing using an abstract incentive delay task PMID 25552570 |
| Neural activity associated with self, other, and object-based counterfactual thinking PMID 25579447 |
| Altered cognition-related brain activity and interactions with acute pain in migraine PMID 25610798 |
| Getting on the same page: The neural basis for social coordination deficits in behavioral variant frontotemporal degener PMID 25619850 |
| Decrease in gamma-band activity tracks sequence learning PMID 25653598 |
| Morphological derivation overflow as a result of disruption of the left frontal aslant white matter tract PMID 25658634 |
| Physics instruction induces changes in neural knowledge representation during successive stages of learning PMID 25665967 |
| Gender Effects in Alcohol Dependence: An fMRI Pilot Study Examining Affective Processing PMID 25684049 |
| Compassion-based emotion regulation up-regulates experienced positive affect and associated neural networks PMID 25698699 |
| The Neuroanatomical Delineation of Agentic and Affiliative Extraversion PMID 25712871 |
| Effects of chronic and acute stimulants on brain functional connectivity hubs PMID 25721787 |
| Distinct neural networks underlying empathy for pleasant and unpleasant touch PMID 25725510 |
| Prediction of brain maturity based on cortical thickness at different spatial resolutions PMID 25731999 |
| The smelling of Hedione results in sex-differentiated human brain activity PMID 25797832 |
| Multiple brain networks contribute to the acquisition of bias in perceptual decision-making PMID 25798082 |
| Frequency-Dependent Changes of Local Resting Oscillations in Sleep-Deprived Brain PMID 25798918 |
| Blink-related dynamic switching between internal and external orienting networks while viewing videos PMID 25828154 |
| Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinkin PMID 25937240 |
| Interhemispheric Functional and Structural Disconnection in Alzheimer’s Disease: A Combined Resting-State fMRI and DTI S PMID 25938561 |
| Relations among EEG-alpha asymmetry and positivity personality trait PMID 25956140 |
| Thirst and the state-dependent representation of incentive stimulus value in human motive circuitry PMID 25971601 |
| Not all declarative memories are created equal: Fast Mapping as a direct route to cortical declarative representations PMID 25988227 |
| Language Differences in the Brain Network for Reading in Naturalistic Story Reading and Lexical Decision PMID 26017384 |
| Neural correlates of active vision: An fMRI comparison of natural reading and scene viewing PMID 26026255 |
| Functional connections between optic flow areas and navigationally responsive brain regions during goal-directed navigat PMID 26054874 |
| Filling in the gaps: Anticipatory control of eye movements in chronic mild traumatic brain injury PMID 26106545 |
| Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures PMID 26109123 |
| The significance of caudate volume for age-related associative memory decline PMID 26119913 |
| Neural correlates of biased social fear learning and interaction in an intergroup context PMID 26166625 |
| Many ways to read your vowels—Neural processing of diacritics and vowel letters in Hebrew PMID 26188258 |
| Response control networks are selectively modulated by attention to rare events and memory load regardless of the need f PMID 26190403 |
| Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study PMID 26208746 |
| Gray matter blood flow and volume are reduced in association with white matter hyperintensity lesion burden: a cross-sec PMID 26217223 |
| Familial risk and ADHD-specific neural activity revealed by case-control, discordant twin pair design PMID 26256128 |
| Effect of Simulated Microgravity on Human Brain Gray Matter and White Matter – Evidence from MRI PMID 26270525 |
| From perceptual to lexico‐semantic analysis—cortical plasticity enabling new levels of processing PMID 26304153 |
| Reading fiction and reading minds: the role of simulation in the default network PMID 26342221 |
| Neurobiological underpinnings of sensation seeking trait in heroin abusers PMID 26364127 |
| Cortical thickness in adults with agenesis of the corpus callosum PMID 26384774 |
| Framing effects reveal discrete lexical-semantic and sublexical procedures in reading: an fMRI study PMID 26441712 |
| Experience of negative emotions in Parkinson’s disease: An fMRI investigation PMID 26497912 |
| Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T PMID 26550990 |
| Spontaneous brain activity following fear reminder of fear conditioning by using resting-state functional MRI PMID 26576733 |
| Multi-Modal Imaging of Neural Correlates of Motor Speed Performance in the Trail Making Test PMID 26579066 |
| Localizing Pain Matrix and Theory of Mind networks with both verbal and non-verbal stimuli PMID 26589334 |
| Corticostriatal pathways contribute to the natural time course of positive mood PMID 26638823 |
| BDNFMethylation and Maternal Brain Activity in a Violence-Related Sample PMID 26649946 |
| Neural correlates of event clusters in past and future thoughts: How the brain integrates specific episodes with autobio PMID 26658926 |
| Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA PMID 26673947 |
| Decreased functional connectivity density in pain-related brain regions of female migraine patients without aura PMID 26688226 |
| Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults PMID 26690806 |
| Effects of Dietary Protein and Fiber at Breakfast on Appetite,ad LibitumEnergy Intake at Lunch, and Neural Responses to PMID 26742068 |
| Altered balance of functional brain networks in Schizophrenia PMID 26786152 |
| Cortical thickness changes in patients with Parkinson's disease and impulse control disorders PMID 26810913 |
| Decreased sleep duration is associated with increased fMRI responses to emotional faces in children PMID 26821063 |
| Visuomotor Dissociation in Cerebral Scaling of Size PMID 26963705 |
| Testosterone Administration Related Differences in Brain Activation during the Ultimatum Game PMID 26973448 |
| The Simpson's paradox and fMRI: Similarities and differences between functional connectivity measures derived from withi PMID 27101735 |
| The Effect of Depo Medroxyprogesterone Acetate (DMPA) on Cerebral Food Motivation Centers: A Pilot Study using Functiona PMID 27129935 |
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| Neural response to modulating the probability that actions of self or other result in auditory tones: A parametric fMRI PMID 27381929 |
| Exploring the Neural Representation of Novel Words Learned through Enactment in a Word Recognition Task PMID 27445918 |
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*Frontal lobe · Mai atlas of record · 457 studies · 90 papers on disk*
The orbitofrontal gyri form the frontal lobe's inferior surface — an H-shaped zigzag complex framed by the olfactory sulcus medially, above the orbits. This is value computation's cortical floor: reward and punishment magnitude, reversal when contingencies flip, decisions flavoured by emotion.
The orbitofrontal gyri form the inferior (orbital) surface of the frontal lobe, an H-shaped or zigzag complex of gyri framed by the olfactory sulcus medially and the orbital sulcus, above the orbit. Cytologically granular dysgranular areas 11/13/47; heavily connected with amygdala, insula and taste/visceral afferents.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 10, Emotion'}*
Value computation: encoding reward and punishment magnitude, reversing learned stimulus–reward associations, and decision-making flavoured by emotion. Famous sequelae of bilateral damage (classically orbitofrontal) are disinhibition, social-ethical lapses and reversal-learning failure with otherwise normal IQ.
The functional record: reward/punishment encoding, stimulus-reward reversal, emotionally flavoured decision-making — and the famous bilateral-damage sequelae (the Phineas Gage literature's orbitofrontal chapter). The decoded profile is food, olfactory, reward, disgust — the orbital surface's flavour-and-value vocabulary. The graded matrix carries the emotional family: emotional-Stroop as stimulator and assessor, facial-emotion as stimulator. Its 90-paper dossier is thin for so central a function — the orbitofrontal literature is scattered across BA 11's and the medial OFC's records.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 12, Cognitive Control'}*
Amygdala (231 shared studies), entorhinal cortex (224), BA 11 (220), uncus (220), olfactory sulcus (205) — the orbital value ring, firing as one circuit.
Co-activation partners of record: Amygdala:231, Entorhinal cortex:224, BA 11 - orbitofrontal:220, Uncus:220, Olfactory sulcus:205, Amygdala:197, Rhinal sulcus:194, Inferior frontal gyrus, orbital part:155.
Bilateral damage: impaired reversal, emotionally-flavoured decision failures, the Gage literature's personality changes. The decoded disgust term marks the insula's neighbour — disgust and value sharing the orbital floor.
10.1016/S0028-3932(99)00132-310.1093/brain/124.1.6710.1016/S0028-3932(01)00161-010.1073/pnas.08211109910.1093/brain/awf093457 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — food(interoception), orbitofrontal(anatomy-reference), ofc(anatomy-reference), olfactory(perception), reward(method-other), orbitofrontal cortex(anatomy-reference), pictures(perception), disgust(emotion) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Amygdala:231, Entorhinal cortex:224, BA 11 - orbitofrontal:220, Uncus:220 — each name is a dossier stop in this explorer.