Structure. The precuneus is the large medial surface of the parietal lobe, wedged between the marginal branch of the cingulate sulcus (in front), the parieto-occipital sulcus (behind) and the subparietal sulcus (below). It is one of the largest single medial cortical masses, heteromodal association in structure, with among the highest resting metabolic rates in the brain.
Function. Posterior hub of the default mode network: the midline posterior cingulate–precuneus band is a principal node of the brain's baseline activity, first mapped as a 'default mode' in Raichle's 2001 analysis. Cognitively it supports episodic memory retrieval, visuospatial imagery, first-person perspective and self-referential thought; its metabolic activity drops during goaldirected external tasks.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stroop ↗ | inhibitor | secondary | highly-credible | delivery | Task-induced deactivation of the precuneus — a reliable default-mode suppression site. |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Decision-Reward Uncertainty fMRI in adolescents: behavioral-risk trials evoked greater activation than reward- |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | fMRI anticipation task: anticipating a larger reward activated precuneus bilaterally, and the incentive conjun |
| mental-rotation ↗ | stimulator | secondary | standard-scientific | delivery | Decoded profile ranks 'spatial' 3rd (0.009) among pcun-m's own associations; mental rotation is the battery's |
| oddball ↗ | stimulator | secondary | standard-scientific | delivery | Decoded profile ranks 'attention' 4th (0.0088) and 'attentional' 12th among pcun-m associations; oddball devia |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Somatosensory needle-stimulation fMRI (acupuncture point vs controls): bilateral precuneus deactivated during |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Reward-feedback fMRI in ADHD children: larger-reward feedback improved visuospatial working memory with task-a |
| antisaccade ↗ | stimulator | secondary | standard-scientific | delivery | ALE meta-analysis of antisaccade fMRI/PET (Jamadar et al. 2013, Table 4): antisaccade > prosaccade converges o |
| nback ↗ | assessor | secondary | standard-scientific | fMRI | n-back fMRI in schizophrenia (Sapara et al. 2014, Table 2): precuneus BA 7 peaks at MNI 6,-52,50 (T=4.33) for |
| mental-rotation ↗ | assessor | secondary | standard-scientific | fMRI | Mental-rotation-task fMRI (Zheng et al. 2023, Table 3): rotation vs comparison engaged precuneus BA 7 (left, 4 |
| gonogo ↗ | assessor | secondary | standard-scientific | fMRI | Go/no-go fMRI (Lee et al. 2015, Table 2): correct no-go vs rest recruited precuneus/posterior cingulate BA 7, |
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| Nature of Functional Links in Valuation Networks Differentiates Impulsive Behaviors between Abstinent Heroin-Dependent S PMID 25944613 |
| A common gustatory and interoceptive representation in the human mid-insula PMID 25950427 |
| The neural substrates for the different modalities of movement imagery PMID 25956141 |
| Discovering networks altered by potential threat (“anxiety”) using Quadratic Discriminant Analysis PMID 25969398 |
| Aberrant Function of Learning and Cognitive Control Networks Underlie Inefficient Cognitive Flexibility in Anorexia Nerv PMID 25970523 |
| Thirst and the state-dependent representation of incentive stimulus value in human motive circuitry PMID 25971601 |
| Functional brain networks involved in reality monitoring PMID 26004062 |
| Longitudinal Cortical Development During Adolescence and Young Adulthood in Autism Spectrum Disorders: Increased Cortica PMID 26004661 |
| The Anterior Insula Tracks Behavioral Entropy during an Interpersonal Competitive Game PMID 26039634 |
| Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson PMID 26046412 |
| What makes your brain suggestible? Hypnotizability is associated with differential brain activity during attention outsi PMID 26049149 |
| Neuroimaging the short- and long-term effects of repeated picture naming in healthy older adults PMID 26071256 |
| Learning temporal statistics for sensory predictions in mild cognitive impairment PMID 26093288 |
| Effects of Intrinsic Motivation on Feedback Processing During Learning PMID 26112370 |
| Feedback associated with expectation for larger-reward improves visuospatial working memory performances in children wit PMID 26142072 |
| Individual differences in verbal creative thinking are reflected in the precuneus PMID 26150204 |
| Neural correlates of fixation duration in natural reading: Evidence from fixation-related fMRI PMID 26151101 |
| Separate and overlapping brain areas encode subjective value during delay and effort discounting PMID 26163803 |
| Thalamocortical Sensorimotor Circuit Damage Associated with Disorders of Consciousness for Diffuse Axonal Injury Patient PMID 26165776 |
| Aberrant functioning of the putamen links delusions, antipsychotic drug dose, and compromised connectivity in first epis PMID 26184459 |
| Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social PMID 26189075 |
| Increased resting-state functional connectivity of visual- and cognitive-control brain networks after training in childr PMID 26199874 |
| A group ICA based framework for evaluating resting fMRI markers when disease categories are unclear: application to schi PMID 26216278 |
| The relation of structural integrity and task-related functional connectivity in the aging brain PMID 26234754 |
| Anger in brain and body: the neural and physiological perturbation of decision-making by emotion PMID 26253525 |
| Permutation and parametric tests for effect sizes in voxel-based morphometry of gray matter volume in brain structural M PMID 26253778 |
| The nature of the language input affects brain activation during learning from a natural language PMID 26257471 |
| Early warning for human mental sub-health based on fMRI data analysis: an example from a seafarers' resting-data study PMID 26257686 |
| Multimodal Connectivity of Motor Learning-Related Dorsal Premotor Cortex PMID 26282855 |
| Numerosity processing is context driven even in the subitizing range: An fMRI study PMID 26297625 |
| Differences in prefrontal cortex activation and deactivation during strategic episodic verbal memory encoding in mild co PMID 26300771 |
| Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent PMID 26363618 |
| Neuroimaging of the joint Simon effect with believed biological and non-biological co-actors PMID 26388760 |
| Negative emotions facilitate isometric force through activation of prefrontal cortex and periaqueductal gray PMID 26400014 |
| Navigating through digital folders uses the same brain structures as real world navigation PMID 26423226 |
| Ventral fronto-parietal contributions to the disruption of visual working memory storage PMID 26436710 |
| Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patient PMID 26448878 |
| Region-specific reduction of auditory sensory gating in older adults PMID 26507900 |
| Vertex Stimulation as a Control Site for Transcranial Magnetic Stimulation: A Concurrent TMS/fMRI Study PMID 26508284 |
| The Reference Ability Neural Network Study: Life-time stability of reference-ability neural networks derived from task m PMID 26522424 |
| A human brain atlas derived via n-cut parcellation of resting-state and task-based fMRI data PMID 26523655 |
| Differences in Neural Activity when Processing Emotional Arousal and Valence in Autism Spectrum Disorders PMID 26526072 |
| Categorical evidence, confidence, and urgency during probabilistic categorization PMID 26564532 |
| Autistic fluid intelligence: Increased reliance on visual functional connectivity with diminished modulation of coupling PMID 26594629 |
| The association between hemispheric specialization for language production and for spatial attention depends on left-han PMID 26626612 |
| Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders PMID 26639982 |
| Classifying individuals at high-risk for psychosis based on functional brain activity during working memory processing PMID 26640767 |
| Expert–novice differences in brain function of field hockey players PMID 26674059 |
| Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging PMID 26688237 |
| The sequential structure of brain activation predicts skill PMID 26707716 |
| A role for left inferior frontal and posterior superior temporal cortex in extracting a syntactic tree from a sentence PMID 26709465 |
| Functional connectivity of the amygdala and subgenual cingulate during cognitive reappraisal of emotions in children wit PMID 26746624 |
| Memory-Guided Attention: Independent Contributions of the Hippocampus and Striatum PMID 26777274 |
| It's Sad but I Like It: The Neural Dissociation Between Musical Emotions and Liking in Experts and Laypersons PMID 26778996 |
| The activation of interactive attentional networks PMID 26794640 |
| An fMRI study of perception and action in deaf signers PMID 26796716 |
| Neural correlates of different self domains PMID 26807336 |
| Brain-based decoding of mentally imagined film clips and sounds reveals experience-based information patterns in film pr PMID 26826515 |
| GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutid PMID 26831302 |
| Distinct medial temporal networks encode surprise during motivation by reward versus punishment PMID 26854903 |
| Effects of Fast Simple Numerical Calculation Training on Neural Systems PMID 26881117 |
| Look into my eyes: Investigating joint attention using interactive eye-tracking and fMRI in a developmental sample PMID 26892856 |
| Neural correlates of processing harmonic expectancy violations in children and adolescents with OCD PMID 26900566 |
| Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major PMID 26954981 |
| Visuomotor Dissociation in Cerebral Scaling of Size PMID 26963705 |
| The influence of androstadienone during psychosocial stress is modulated by gender, trait anxiety and subjective stress: PMID 26970712 |
| Increased resting state connectivity between ipsilesional motor cortex and contralesional premotor cortex after transcra PMID 26980052 |
| Supersize my brain: A cross-sectional voxel-based morphometry study on the association between self-reported dietary res PMID 26995784 |
| Mothers with depressive symptoms display differential brain activations when empathizing with infant faces PMID 27000301 |
| Functional brain substrate of quality of life in patients with schizophrenia: A brain SPECT multidimensional analysis PMID 27000309 |
| Neural basis of reward anticipation and its genetic determinants PMID 27001827 |
| The Yin and the Yang of Prediction: An fMRI Study of Semantic Predictive Processing PMID 27010386 |
| Toward Semantics in the Wild: Activation to Manipulable Nouns in Naturalistic Reading PMID 27053211 |
| The Simpson's paradox and fMRI: Similarities and differences between functional connectivity measures derived from withi PMID 27101735 |
| Auditory motion in the sighted and blind: Early visual deprivation triggers a large-scale imbalance between auditory and PMID 27107468 |
| Changes in Effective Connectivity of the Superior Parietal Lobe during Inhibition and Redirection of Eye Movements PMID 27147827 |
| Working Memory Network Changes in ALS: An fMRI Study PMID 27147950 |
| Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glut PMID 27182810 |
| Mapping of the Underlying Neural Mechanisms of Maintenance and Manipulation in Visuo-Spatial Working Memory Using An n-b PMID 27199694 |
| Increase or Decrease of fMRI Activity in Adult Attention Deficit/ Hyperactivity Disorder: Does It Depend on Task Difficu PMID 27207920 |
| The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture PMID 27230218 |
| Variable activation in striatal subregions across components of a social influence task in young adult cannabis users PMID 27257518 |
| Spontaneous pupil dilations during the resting state are associated with activation of the salience network PMID 27291493 |
| Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades PMID 27378909 |
| Competition between Visual Events Modulates the Influence of Salience during Free-Viewing of Naturalistic Videos PMID 27445760 |
| Impact of Short Social Training on Prosocial Behaviors: An fMRI Study PMID 27458349 |
| Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in neg PMID 27474908 |
| Neural signatures of experience-based improvements in deterministic decision-making PMID 27523644 |
| Distinct functional properties of the vertical and horizontal saccadic network in Health and Parkinson's disease: An eye PMID 27545665 |
| Stimulus-Driven Reorienting Impairs Executive Control of Attention: Evidence for a Common Bottleneck in Anterior Insula PMID 27550866 |
| The Neural System of Postdecision Evaluation in Rostral Frontal Cortex during Problem-solving Tasks PMID 27595134 |
| Episodic specificity induction impacts activity in a core brain network during construction of imagined future experienc PMID 27601666 |
| Noise Reduction in Arterial Spin Labeling Based Functional Connectivity Using Nuisance Variables PMID 27601973 |
| Increased Brain Activation for Dual Tasking with 70-Days Head-Down Bed Rest PMID 27601982 |
| Age-related differences in brain activity during implicit and explicit processing of fearful facial expressions PMID 27614138 |
| Absence of visual experience modifies the neural basis of numerical thinking PMID 27638209 |
| Mental representations of vowel features asymmetrically modulate activity in superior temporal sulcus PMID 27669107 |
| Bilateral parietal contributions to spatial language PMID 27690125 |
| Effects of craving behavioral intervention on neural substrates of cue-induced craving in Internet gaming disorder PMID 27699148 |
| Structural Abnormalities in Childhood Absence Epilepsy: Voxel-Based Analysis Using Diffusion Tensor Imaging PMID 27733824 |
| Mentalizing in schizophrenia: A multivariate functional MRI study PMID 27793657 |
| The rTPJ’s overarching cognitive function in networks for attention and theory of mind PMID 27798260 |
| Gaming is related to enhanced working memory performance and task-related cortical activity PMID 27815094 |
| Interaction Effects of BDNF and COMT Genes on Resting-State Brain Activity and Working Memory PMID 27853425 |
| Disrupted functional connectivity affects resting state based language lateralization PMID 27882297 |
| Functional and Structural Signatures of the Anterior Insula are associated with Risk-taking Tendency of Analgesic Decisi PMID 27892543 |
| Neural correlates of the affective properties of spontaneous and volitional laughter types PMID 27940151 |
| Regional Brain Responses Are Biased Toward Infant Facial Expressions Compared to Adult Facial Expressions in Nulliparous PMID 27977692 |
| Disentangling meaning in the brain: Left temporal involvement in agreement processing PMID 27984788 |
| Brain networks underlying novel metaphor production PMID 28038366 |
| A Reduction in Delay Discounting by Using Episodic Future Imagination and the Association with Episodic Memory Capacity PMID 28105009 |
| Unsmoothed functional MRI of the human amygdala and bed nucleus of the stria terminalis during processing of emotional f PMID 28108394 |
| Long-Term Experience of Chinese Calligraphic Handwriting Is Associated with Better Executive Functions and Stronger Rest PMID 28129407 |
| Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in an adult lifespan sam PMID 28138504 |
| The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functio PMID 28213119 |
| Brain activation to task-irrelevant disorder-related threat in social anxiety disorder: The impact of symptom severity PMID 28224080 |
| Functional connectivity between prefrontal and parietal cortex drives visuo-spatial attention shifts PMID 28254653 |
| Cross-cultural differences in the neural correlates of specific and general recognition PMID 28256199 |
| Imagining the future: The core episodic simulation network dissociates as a function of timecourse and the amount of sim PMID 28324695 |
| Not in one metric: Neuroticism modulates different resting state metrics within distinctive brain regions PMID 28342970 |
| Systematic Comparison of Brain Imaging Meta-Analyses of ToM with vPT PMID 28367446 |
| Neurophysiological capacity in a working memory task differentiates dependent from nondependent heavy drinkers and contr PMID 28376413 |
| Latent and Abnormal Functional Connectivity Circuits in Autism Spectrum Disorder PMID 28377688 |
| Neural evidence for phonologically based language production deficits in older adults: An fMRI investigation of age‐rela PMID 28413708 |
| Mapping Dorsal and Ventral Caudate in Older Adults: Method and Validation PMID 28420985 |
| Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting f PMID 28469197 |
| A meta‐analysis of functional magnetic resonance imaging studies of eye movements and visual word reading PMID 28523225 |
| Electrocorticography of Spatial Shifting and Attentional Selection in Human Superior Parietal Cortex PMID 28553217 |
| Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols PMID 28577338 |
| Differential Functional Connectivity Alterations of Two Subdivisions within the Right dlPFC in Parkinson's Disease PMID 28611616 |
| Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low PMID 28649490 |
| Reading network in dyslexia: Similar, yet different PMID 28715717 |
| FMRI to probe sex-related differences in brain function with multitasking PMID 28759619 |
| Functional neural bases of numerosity judgments in healthy adults born preterm PMID 28802184 |
| Using resting-state fMRI to assess the effect of aerobic exercise on functional connectivity of the DLPFC in older overw PMID 28844505 |
| Neural congruence between intertemporal and interpersonal self-control: Evidence from delay and social discounting PMID 28877515 |
| The role of auditory cortex in the spatial ventriloquism aftereffect PMID 28889003 |
*Parietal lobe · Mai atlas of record · 797 studies · 142 papers on disk*
The precuneus is the default mode network's posterior hub — the large medial parietal surface wedged between the cingulate sulcus, the parieto-occipital sulcus and the superior margin, a principal node of the brain's baseline activity, first mapped as 'default mode' there.
The precuneus is the large medial surface of the parietal lobe, wedged between the marginal branch of the cingulate sulcus (in front), the parieto-occipital sulcus (behind) and the subparietal sulcus (below). It is one of the largest single medial cortical masses, heteromodal association in structure, with among the highest resting metabolic rates in the brain.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y −82.3…−38.0 mm, 28 plates (labels PCu)'}*
Posterior hub of the default mode network: the midline posterior cingulate–precuneus band is a principal node of the brain's baseline activity, first mapped as a 'default mode' in Raichle's 2001 analysis. Cognitively it supports episodic memory retrieval, visuospatial imagery, first-person perspective and self-referential thought; its metabolic activity drops during goaldirected external tasks.
The functional record: posterior hub of the default mode network — the midline posterior cingulate-precuneus band. The decoded profile is precuneus, network, spatial, attention — the hub's roles span self-referential thought, spatial orientation and attentional reorientation. The graded matrix carries the executive family as inhibitors: Stroop (highly-credible), flanker and Simon (standard) — task-positive performance suppresses this resting hub, the deactivation physiology recorded as grades.
*— {'source': 'Raichle, MacLeod, Snyder, Powers, Gusnard & Shulman', 'work': 'A default mode of brain function, Proc Natl Acad Sci U S A 2001', 'locator': 'midline areas within the posterior cingulate and precuneus', 'kind': 'paper'}*
*— {'source': 'Yeo, Krienen, Sepulcre et al.', 'work': 'The organization of the human cerebral cortex estimated by intrinsic functional connectivity, J Neurophysiol 2011', 'locator': 'pCun among the default-network seeds', 'kind': 'paper'}*
Intraparietal sulcus (444 shared studies), anterior cingulate (360), paracingulate (337), premotor (308) — the hub's partners across default and control networks.
Co-activation partners of record: Intraparietal sulcus:444, Cingulate gyrus, anterior:360, Paracingulate gyrus:337, BA 6 - premotor/SMA:308, Superior occipital gyrus:277, Superior parietal lobule:269, Inferior frontal gyrus, opercular part:250, Isthmus of cingulate gyrus:247.
The hub's failures: disorders of awareness and the resting-state's dysregulation in Alzheimer's (the pCC-precuneus band's early hypometabolism, recorded on the pCC's dossier) — and the deactivation failures the inhibitor grades measure.
10.1016/S0926-6410(98)00031-710.1093/cercor/9.1.2010.1016/S0920-9964(98)00141-810.1093/brain/122.6.109310.1016/S0028-3932(99)00053-6797 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — precuneus(anatomy-reference), network(anatomy-reference), spatial(method-other), attention(cognition), networks(anatomy-reference), parietal(anatomy-reference), task(method-other), default(cognition) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Intraparietal sulcus:444, Cingulate gyrus, anterior:360, Paracingulate gyrus:337, BA 6 - premotor/SMA:308 — each name is a dossier stop in this explorer.