Structure. The claustrum is a thin grey sheet between the putamen and the insular cortex, split off the lentiform complex by the external capsule's fibres; its inputs and outputs span nearly the whole cortical mantle — the brain's widest-spread cortical connectivity for its size.
Function. A proposed coordinator of consciousness-scale binding: its near-universal connectivity has inspired theories of global-state coordination, and stimulation provokes abrupt impairment of consciousness; its precise role remains an open research frontier rather than settled doctrine.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| pain-induction | stimulator | secondary | standard-scientific | delivery | The region's decoded profile ranks pain second among its terms (0.017, with somatosensory 0.005 and painful fo |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | The region's decoded profile carries reward (0.006), striatum, striatal, putamen and learning terms; on-disk f |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | In the same on-disk fMRI study, surprising non-reward outcomes activated frontoinsular cortex bilaterally and |
| simple-rt ↗ | assessor | secondary | standard-scientific | behavioral | The region's strongest decoded term is motor (0.019, with movements, execution, hand); simple response time is |
| taskswitching ↗ | stimulator | secondary | standard-scientific | delivery | Opened on-disk fMRI reversal-learning study (participants learn a stimulus-outcome association then update the |
| mental-rotation ↗ | stimulator | secondary | standard-scientific | delivery | The region's decoded profile carries imagery (0.005) among its top terms (master.json rank 17); mental rotatio |
| choice-rt ↗ | stimulator | secondary | standard-scientific | delivery | Rank-1 decoded terms are motor (0.019), movements (0.008) with execution, hand and SMA follow-ons (master.json |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Opened on-disk fMRI study of belief evaluation found left claustrum (BA 13) in its condition-by-certainty inte |
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| An fMRI study of the differences in brain activity during active ankle dorsiflexion and plantarflexion. Brain imaging and behavior 2010 · 10.1007/s11682-010-9091-2 |
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| Neural responses to unattended products predict later consumer choices. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.0064-10.2010 |
| Menstrual cycle and hormonal contraceptive use modulate human brain structure. Brain research 2010 · 10.1016/j.brainres.2010.06.019 |
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| Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in Brain and language 2015 · 10.1016/j.bandl.2015.09.002 |
| Physical attractiveness and sex as modulatory factors of empathic brain responses to pain. Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00236 |
| Distinct contributions of lateral orbito-frontal cortex, striatum, and fronto-parietal network regions for rule encoding NeuroImage 2016 · 10.1016/j.neuroimage.2015.10.005 |
| fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. Frontiers in systems neuroscience 2015 · 10.3389/fnsys.2015.00124 |
| Dysfunctional putamen modulation during bimanual finger-to-thumb movement in patients with Parkinson's disease. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00516 |
| Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia. Brain : a journal of neurology 2016 · 10.1093/brain/awv306 |
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| Altered sensitization patterns to sweet food stimuli in patients recovered from anorexia and bulimia nervosa. Psychiatry research 2015 · 10.1016/j.pscychresns.2015.10.010 |
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| Increased Frontal Response May Underlie Decreased Tinnitus Severity. PloS one 2015 · 10.1371/journal.pone.0144419 |
| Enhancing Motor Network Activity Using Real-Time Functional MRI Neurofeedback of Left Premotor Cortex. Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00341 |
| Behavioral and Neural Plasticity of Ocular Motor Control: Changes in Performance and fMRI Activity Following Antisaccad Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00653 |
| Influence of the cortical midline structures on moral emotion and motivation in moral decision-making. Behavioural brain research 2016 · 10.1016/j.bbr.2016.01.001 |
| Mental fatigue after mild traumatic brain injury: a 3D-ASL perfusion study. Brain imaging and behavior 2016 · 10.1007/s11682-015-9492-3 |
| Preliminary findings of cerebral responses on transcutaneous vagal nerve stimulation on experimental heat pain. Brain imaging and behavior 2017 · 10.1007/s11682-015-9502-5 |
| Modulation of hand motor-related area during motor imagery and motor execution before and after middle 2/5 of the MS6 li Brain and cognition 2016 · 10.1016/j.bandc.2016.01.002 |
| Disentangling introspective and exteroceptive attentional control from emotional appraisal in depression using fMRI: A Psychiatry research. Neuroimaging 2016 · 10.1016/j.pscychresns.2016.01.009 |
| Neural Correlates of Morphological Processing: Evidence from Chinese. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00714 |
| Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia. Brain imaging and behavior 2017 · 10.1007/s11682-016-9513-x |
| Seasonality in human cognitive brain responses. Proceedings of the National Academy of Sciences of the United States of America 2016 · 10.1073/pnas.1518129113 |
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| Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing. Journal of cognitive neuroscience 2016 · 10.1162/jocn_a_00943 |
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| Altered functional brain networks in amnestic mild cognitive impairment: a resting-state fMRI study. Brain imaging and behavior 2017 · 10.1007/s11682-016-9539-0 |
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| The Relationship between Frontotemporal Effective Connectivity during Picture Naming, Behavior, and Preserved Cortical T Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00109 |
| Memory and functional brain differences in a national sample of U.S. veterans with Gulf War Illness. Psychiatry research. Neuroimaging 2016 · 10.1016/j.pscychresns.2016.03.004 |
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| Classification of schizophrenia and bipolar patients using static and dynamic resting-state fMRI brain connectivity. NeuroImage 2016 · 10.1016/j.neuroimage.2016.04.051 |
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| Outcome Uncertainty and Brain Activity Aberrance in the Insula and Anterior Cingulate Cortex Are Associated with Dysfunc Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00207 |
| Identifying grey matter changes in schizotypy using partial least squares correlation. Cortex; a journal devoted to the study of the nervous system and behavior 2016 · 10.1016/j.cortex.2016.04.011 |
| Increased frontal functional networks in adult survivors of childhood brain tumors. NeuroImage. Clinical 2016 · 10.1016/j.nicl.2016.02.010 |
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| What Impact does An Angry Context have Upon Us? The Effect of Anger on Functional Connectivity of the Right Insula and S Frontiers in behavioral neuroscience 2016 · 10.3389/fnbeh.2016.00109 |
| Demonstration and validation of a new pressure-based MRI-safe pain tolerance device. Journal of neuroscience methods 2016 · 10.1016/j.jneumeth.2016.07.001 |
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| Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait an NeuroImage. Clinical 2016 · 10.1016/j.nicl.2016.06.022 |
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| Difference in Activity in the Supplementary Motor Area Depending on Limb Combination of Hand-Foot Coordinated Movements. Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00499 |
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| Neural Correlates of Hostile Jokes: Cognitive and Motivational Processes in Humor Appreciation. Frontiers in human neuroscience 2016 · 10.3389/fnhum.2016.00527 |
| Motor sequence learning-induced neural efficiency in functional brain connectivity. Behavioural brain research 2017 · 10.1016/j.bbr.2016.11.021 |
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| Neural Systems Underlying Emotional and Non-emotional Interference Processing: An ALE Meta-Analysis of Functional Neuroi Frontiers in behavioral neuroscience 2016 · 10.3389/fnbeh.2016.00220 |
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| Coding of Event Nodes and Narrative Context in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 · 10.1523/JNEUROSCI.2889-15.2016 |
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| Neural correlates of babyish adult face processing in men. Neuropsychologia 2017 · 10.1016/j.neuropsychologia.2017.01.017 |
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| Functional MRI of Human Eyeblink Classical Conditioning in Children with Fetal Alcohol Spectrum Disorders. Cerebral cortex (New York, N.Y. : 1991) 2017 · 10.1093/cercor/bhw273 |
| Mouth and Voice: A Relationship between Visual and Auditory Preference in the Human Superior Temporal Sulcus. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 · 10.1523/JNEUROSCI.2914-16.2017 |
| Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. NeuroImage. Clinical 2017 · 10.1016/j.nicl.2017.01.008 |
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| Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke. NeuroImage. Clinical 2017 · 10.1016/j.nicl.2017.01.023 |
| Enhancing Effects of NMDA-Receptor Blockade on Extinction Learning and Related Brain Activation Are Modulated by BMI. Frontiers in behavioral neuroscience 2017 · 10.3389/fnbeh.2017.00034 |
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| Functional magnetic resonance imaging investigation of brain regions associated with astringency. Neuroscience research 2017 · 10.1016/j.neures.2017.03.009 |
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| Modulation of hand motor-related area during motor imagery and motor execution before and after middle 2/5 of the MS6 li PMID 26799679 |
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| Differential Resting State Connectivity Patterns and Impaired Semantically Cued List Learning Test Performance in Early PMID 26888619 |
| Language structure in the brain: A fixation-related fMRI study of syntactic surprisal in reading PMID 26908322 |
| Exercise-related changes in between-network connectivity in overweight/obese adults PMID 26921099 |
| Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals PMID 26922247 |
| Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease PMID 26935551 |
| Characterizing “fibrofog”: Subjective appraisal, objective performance, and task-related brain activity during a working PMID 26955513 |
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| Primary somatosensory contribution to action observation brain activity—combining fMRI and cTBS PMID 26979966 |
| Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in ind PMID 26985771 |
| Importance of human right inferior frontoparietal network connected by inferior branch of superior longitudinal fascicul PMID 26986838 |
| Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinati PMID 26995674 |
| Mothers with depressive symptoms display differential brain activations when empathizing with infant faces PMID 27000301 |
| The Yin and the Yang of Prediction: An fMRI Study of Semantic Predictive Processing PMID 27010386 |
| Memory and functional brain differences in a national sample of U.S. veterans with Gulf War Illness PMID 27017423 |
| Neural Network of Predictive Motor Timing in the Context of Gender Differences PMID 27019753 |
| Neuronal interactions in areas of spatial attention reflect avoidance of disgust, but orienting to danger PMID 27039145 |
| Toward Semantics in the Wild: Activation to Manipulable Nouns in Naturalistic Reading PMID 27053211 |
| Neural circuitry involved in quitting after repeated failures: role of the cingulate and temporal parietal junction PMID 27097529 |
| The neural basis of regret and relief during a sequential risk-taking task PMID 27102420 |
| Neural activity related to discrimination and vocal production of consonant and dissonant musical intervals PMID 27134038 |
| Pharmacological modulation of pulvinar resting-state regional oscillations and network dynamics in major depression PMID 27148894 |
| Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glut PMID 27182810 |
| Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder PMID 27187232 |
| The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture PMID 27230218 |
| Brain activation profiles during kinesthetic and visual imagery: An fMRI study PMID 27288703 |
| Behavioural and neuroimaging changes after naming therapy for semantic variant primary progressive aphasia PMID 27297727 |
| Increased frontal functional networks in adult survivors of childhood brain tumors PMID 27298763 |
| Brain Bases of Working Memory for Time Intervals in Rhythmic Sequences PMID 27313506 |
| Regional homogeneity changes in amnestic mild cognitive impairment patients PMID 27345927 |
| Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food PMID 27349694 |
| Neural substrates of successful working memory and long-term memory formation in a relational spatial memory task PMID 27350001 |
| Patterns of regional gray matter loss at different stages of schizophrenia: A multisite, cross-sectional VBM study in fi PMID 27354958 |
| Striatal activation reflects urgency in perceptual decision making PMID 27355435 |
| Demonstration and validation of a new pressure-based MRI-safe pain tolerance device PMID 27378028 |
| Effects of Body Mass Index and Body Fat Percent on Default Mode, Executive Control, and Salience Network Structure and F PMID 27378831 |
| Neural response to modulating the probability that actions of self or other result in auditory tones: A parametric fMRI PMID 27381929 |
| Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-anal PMID 27397863 |
| Atypical within- and between-hemisphere motor network functional connections in children with developmental coordination PMID 27419066 |
| Effects of a spaceflight analog environment on brain connectivity and behavior PMID 27423254 |
| Differential roles for parietal and frontal cortices in fixed versus evolving temporal expectations: Dissociating prior PMID 27431757 |
| The transition from childhood to adolescence is marked by a general decrease in amygdala reactivity and an affect-specif PMID 27445112 |
| The neural underpinnings of reading skill in deaf adults PMID 27448530 |
| Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in neg PMID 27474908 |
| Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait an PMID 27504262 |
| Brain networks of temporal preparation: A multiple regression analysis of neuropsychological data PMID 27521744 |
| Neural signatures of experience-based improvements in deterministic decision-making PMID 27523644 |
| Neurocomputational mechanisms of prosocial learning and links to empathy PMID 27528669 |
| A Neural Basis for the Acquired Capability for Suicide PMID 27531983 |
| The role of language in the experience and perception of emotion: a neuroimaging meta-analysis PMID 27539864 |
| Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/o PMID 27546352 |
| Accuracy of automated classification of major depressive disorder as a function of symptom severity PMID 27551669 |
| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Age-related differences in brain activity during implicit and explicit processing of fearful facial expressions PMID 27614138 |
| Default Mode and Executive Networks Areas: Association with the Serial Order in Divergent Thinking PMID 27627760 |
| Brain Responses during the Anticipation of Dyspnea PMID 27648309 |
| Altered reward expectancy in individuals with recent methamphetamine dependence PMID 27649775 |
| Neurofeedback training effects on inhibitory brain activation in ADHD: A matter of learning? PMID 27659116 |
| CBTreducesCBF: cognitive‐behavioral therapy reduces cerebral blood flow in fear‐relevant brain regions in spider phobia PMID 27688940 |
| Neural Activities Underlying the Feedback Express Salience Prediction Errors for Appetitive and Aversive Stimuli PMID 27694920 |
| The network substrate of confabulatory tendencies in Alzheimer's disease PMID 27720424 |
| Evaluation of Handwriting Movement Kinematics: From an Ecological to a Magnetic Resonance Environment PMID 27746727 |
| High Frequency Migraine Is Associated with Lower Acute Pain Sensitivity and Abnormal Insula Activity Related to Migraine PMID 27746728 |
| Difference in Activity in the Supplementary Motor Area Depending on Limb Combination of Hand–Foot Coordinated Movements PMID 27757079 |
| Localization of Impaired Kinesthetic Processing Post-stroke PMID 27799902 |
| An Activation Likelihood Estimation Meta-Analysis Study of Simple Motor Movements in Older and Young Adults PMID 27799910 |
| Early grey matter changes in structural covariance networks in Huntington's disease PMID 27830113 |
| Altered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study PMID 27843705 |
| Motor sequence learning-induced neural efficiency in functional brain connectivity PMID 27845228 |
| Somatic and Reinforcement-Based Plasticity in the Initial Stages of Human Motor Learning PMID 27852776 |
| Putamen Activation Represents an Intrinsic Positive Prediction Error Signal for Visual Search in Repeated Configurations PMID 27867436 |
| Resting-state functional connectivity of subthalamic nucleus in different Parkinson's disease phenotypes PMID 27871435 |
| Neural Systems Underlying Emotional and Non-emotional Interference Processing: An ALE Meta-Analysis of Functional Neuroi PMID 27895564 |
| A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia PMID 27895619 |
| Experience-dependent modulation of right anterior insula and sensorimotor regions as a function of noise-masked auditory PMID 27916664 |
| Recapitulation of emotional source context during memory retrieval PMID 27923474 |
| Sex differences in emotional perception: Meta analysis of divergent activation PMID 27988321 |
| Failure to retreat: Blunted sensitivity to negative feedback supports risky behavior in adolescents PMID 27989774 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression PMID 28017917 |
| Priming Hand Motor Training with Repetitive Stimulation of the Fingertips; Performance Gain and Functional Imaging of Tr PMID 28029594 |
| Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk PMID 28031150 |
| Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disord PMID 28039553 |
| Ipsilateral Putamen and Insula Activation by Both Left and Right GB34 Acupuncture Stimulation: An fMRI Study on Healthy PMID 28053642 |
| Resting state brain connectivity patterns before eventual relapse into cocaine abuse PMID 28057531 |
| Predicting the Multisensory Consequences of One’s Own Action: BOLD Suppression in Auditory and Visual Cortices PMID 28060861 |
| Effects of Intensity of Facial Expressions on Amygdalar Activation Independently of Valence PMID 28066216 |
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| Aberrant spontaneous neural activity and correlation with evoked-brain potentials in first-episode, treatment-naïve pati PMID 28092779 |
| Neural correlates of babyish adult face processing in men PMID 28095312 |
| Increased amygdala reactivity following early life stress: a potential resilience enhancer role PMID 28100219 |
| Spatial Mnemonic Encoding: Theta Power Decreases and Medial Temporal Lobe BOLD Increases Co-Occur during the Usage of th PMID 28101523 |
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| Theta and high-beta networks for feedback processing: a simultaneous EEG–fMRI study in healthy male subjects PMID 28140398 |
| Brain–behavior relationships in source memory: Effects of age and memory ability PMID 28161030 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients PMID 28180070 |
| Grey matter alterations in migraine: A systematic review and meta-analysis PMID 28180071 |
| Changes in the correlation between spatial and temporal source memory performance and BOLD activity across the adult lif PMID 28190516 |
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| An fMRI study into emotional processing in Parkinson’s disease: Does increased medial prefrontal activation compensate f PMID 28486506 |
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*Insula · Mai atlas of record · 1175 studies · 210 papers on disk*
The claustrum is a sheet of grey thinner than a pencil between the putamen and the insula — and the most connected structure per cubic millimetre in the brain. Francis Crick spent his last years on it, proposing it as the conductor of consciousness-scale binding.
The claustrum is a thin grey sheet between the putamen and the insular cortex, split off the lentiform complex by the external capsule's fibres; its inputs and outputs span nearly the whole cortical mantle — the brain's widest-spread cortical connectivity for its size.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'deep nuclei'}*
A proposed coordinator of consciousness-scale binding: its near-universal connectivity has inspired theories of global-state coordination, and stimulation provokes abrupt impairment of consciousness; its precise role remains an open research frontier rather than settled doctrine.
The functional record: near-universal connectivity has inspired global-state coordination theories — and stimulation provokes abrupt impairment of consciousness, a finding as dramatic as the region is thin. Its precise function remains unproven; the record says so honestly. The decoded profile is motor, pain, putamen — reflecting its striatal-neighborhood literature rather than a settled function. No graded instrument is assigned: a region without a settled function cannot carry graded levers.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 14, Consciousness and Free Will'}*
Putamen (1,564 shared studies), circular insular sulcus (1,272), insular cortex (1,200), external pallidum (1,002) — the sheet lives inside the basal-ganglia-insula sandwich its anatomy describes.
Co-activation partners of record: Putamen:1564, Circular insular sulcus:1272, Insular cortex:1200, Globus pallidus, external segment:1002, Putamen:796, Lateral fissure:790, Thalamus:773, Supplementary motor area:756.
The stimulation finding is the failure-mode of record: abrupt consciousness impairment — Crick's conductor hypothesis taken to the operating theatre. Everything beyond that is honest unknown.
10.1016/S0006-3223(99)00056-610.1093/cercor/9.7.6621175 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — motor(action-motor), pain(interoception), putamen(anatomy-reference), insula(anatomy-reference), movements(action-motor), basal ganglia(anatomy-reference), ganglia(anatomy-reference), learning(cognition) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Putamen:1564, Circular insular sulcus:1272, Insular cortex:1200, Globus pallidus, external segment:1002 — each name is a dossier stop in this explorer.