Structure. Brodmann area 10: the largest granular prefrontal field in humans — the frontopolar mass rostral to area 9/46, disproportionately expanded in our species.
Function. Branch-point cognition: holding one goal while pursuing another (secondary-task interleaving), episodic future simulation, and meta-level integration of subgoals — the pole's activation signature is 'thought about thought's targets'.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| flanker ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| simon ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| gonogo ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| stopsignal ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| nback ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| ravens ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| arithmetic ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| tol ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| taskswitching ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| cpt ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| antisaccade ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| wcst ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: demanding executive performance suppresses this member of the default mode network |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Placebo-analgesia fMRI with brief laser pain: left BA10 (MNI -6, 44, 34) among areas modulated during pain ant |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Decision-Reward Uncertainty fMRI in adolescents: behavioral-risk trials evoked greater activation than reward- |
| choice-rt ↗ | stimulator | secondary | standard-scientific | delivery | Action-selection race-model fMRI: fronto-polar cortex (10) showed greater activation for chosen than externall |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Fair-Trade label valuation fMRI (n=40, willingness-to-pay bidding): FT>conventional labeling increased activat |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | Threat-assessment fMRI (pictures/sentences/sounds, concurrent SCR): 'threatening' vs 'harmless' judgments evok |
| choice-rt ↗ | assessor | secondary | standard-scientific | fMRI | Visuomotor choice fMRI with sliding-window entropy: frontopolar BOLD negatively correlated with Shannon entrop |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Frontal-pole ROI activity during behavioral- and reward-risk conditions correlated positively with age across |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Anticipatory BA10 modulation appeared in sham-conditioning and placebo-analgesia stages versus told-inactive c |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Trial-by-trial threatening-vs-harmless behavioral assessments, entered with phasic SCR regressors in a psycho- |
| nback ↗ | assessor | secondary | standard-scientific | fMRI | Region's decoded Neurosynth association profile ranks 'working memory' 4th of 250 terms (association 0.008 acr |
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| Kinematics in the brain: unmasking motor control strategies? PMID 28573311 |
| Functional Connectivity in Frontoparietal Network: Indicator of Preoperative Cognitive Function and Cognitive Outcome Fo PMID 28583454 |
| Attempts at memory control induce dysfunctional brain activation profiles in Generalized Anxiety Disorder: An explorator PMID 28599173 |
| Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study PMID 28626785 |
| Neural activity during attentional conflict predicts reduction in tinnitus perception following rTMS PMID 28629874 |
| Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low PMID 28649490 |
| Noradrenergic modulation of neural erotic stimulus perception PMID 28683981 |
| Functional Connectivity Differences in the Insular Sub-regions in Migraine without Aura: A Resting-State Functional Magn PMID 28701932 |
| Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia PMID 28719572 |
| Activity in part of the neural correlates of consciousness reflects integration PMID 28753443 |
| Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults PMID 28756237 |
| The Neural Bases of Event Monitoring across Domains: a Simultaneous ERP-fMRI Study PMID 28785212 |
| Neurological evaluation of the selection stage of metaphor comprehension in individuals with and without autism spectrum PMID 28802915 |
| d-Cycloserine facilitates extinction learning and enhances extinction-related brain activation PMID 28807795 |
| Lateral frontal pole and relational processing: Activation patterns and connectivity profile PMID 28811179 |
| Test-Retest Reliability of “High-Order” Functional Connectivity in Young Healthy Adults PMID 28824362 |
| Lexical-Semantic Search Under Different Covert Verbal Fluency Tasks: An fMRI Study PMID 28848407 |
*Frontal lobe · Mai atlas of record · 843 studies · 150 papers on disk*
Area 10 is the largest granular prefrontal field in the human brain — disproportionately ours — and its job is the most abstract thing cortex does: hold a goal in reserve while pursuing another, and simulate futures that have not happened.
Brodmann area 10: the largest granular prefrontal field in humans — the frontopolar mass rostral to area 9/46, disproportionately expanded in our species.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 12, Cognitive Control'}*
Branch-point cognition: holding one goal while pursuing another (secondary-task interleaving), episodic future simulation, and meta-level integration of subgoals — the pole's activation signature is 'thought about thought's targets'.
The functional record calls it branch-point cognition: secondary-task interleaving, episodic future simulation, meta-integration of subgoals. The decoded profile is memory, retrieval, episodic — this is where remembering and imagining trade machinery. Note the graded matrix's striking pattern: Stroop, flanker and Simon are all recorded as inhibitors — frontopolar activity is suppressed during response conflict, because its branch-point work yields the floor to the executive networks handling the task at hand.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 12, Cognitive Control'}*
Its partners are the frontoparietal control corridor: intraparietal sulcus (390), paracingulate (389), anterior cingulate (380), inferior frontal operculum (338). The pole talks to whichever network the current branch requires — which is precisely its job description.
Co-activation partners of record: Intraparietal sulcus:390, Paracingulate gyrus:389, Cingulate gyrus, anterior:380, Inferior frontal gyrus, opercular part:338, Inferior frontal sulcus:307, BA 6 - premotor/SMA:286, Thalamus:273, Thalamus:270.
Lesion evidence in the functional record ties frontopolar damage to disorganized, concrete, one-thing-at-a-time behavior — intelligence superficially intact, planning collapsed. With 843 studies it is thinly recorded next to its neighbours; the region's depth is conceptual, not bibliometric.
10.1093/cercor/9.8.80510.1016/S0926-6410(99)00033-610.1016/S0028-3932(99)00068-810.1093/brain/123.8.172210.1016/S0926-6410(00)00029-X843 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — memory(cognition), prefrontal(anatomy-reference), retrieval(method-other), working memory(method-other), working(method-other), prefrontal cortex(anatomy-reference), task(method-other), episodic(cognition) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Intraparietal sulcus:390, Paracingulate gyrus:389, Cingulate gyrus, anterior:380, Inferior frontal gyrus, opercular part:338 — each name is a dossier stop in this explorer.