Structure. The insula is a pyramidal hidden lobe folded deep within the lateral (Sylvian) fissure, capped by the frontal, parietal and temporal opercula. Its surface divides into an anterior part — three short gyri — and a posterior part with two long gyri, separated by the central sulcus of the insula, and ringed by the circular sulcus, which separates it from the opercula. Cytoarchitectonically it is agranular/dysgranular allocortex-adjacent: a three-to-five-layer cortex unlike the six-layer neocortex of the lobes.
Function. Interoceptive cortex: the insula maps the body's internal state — pain, temperature, visceral sensation, taste — integrating it with emotion and salience assignment. Anterior insula couples interoception with executive control and awareness; posterior insula carries primary interosensory representation. It is a hub of the salience network, toggling between the default-mode and central-executive networks.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Insular risk-signal processing accompanies deck selection. |
| oddball ↗ | stimulator | primary | standard-scientific | delivery | Anterior insular salience for the unexpected stimulus. |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Insular feeling-state resonance with the expression. |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Insular signal for punishment and risk. |
| pain-induction | stimulator | primary | highly-credible | delivery | Posterior insula — the pain intensity map. |
| cyberball ↗ | stimulator | primary | standard-scientific | delivery | Anterior insular distress signal during exclusion — same adjudication caveat as dACC. |
| oddball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Reward prediction errors recruit the insula: this on-disk task-fMRI study reports that surprising non-rewards |
| simple-rt ↗ | stimulator | secondary | standard-scientific | delivery | Intrinsic-alertness (arousal) fMRI places insula in the alertness network: right insula chiefly, with addition |
| pain-induction | inhibitor | secondary | standard-scientific | delivery | Repeated identical thermode heat pain (~47C, right volar forearm) under rt-fMRI neurofeedback: left AIC target |
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| Tuning-in to the beat: Aesthetic appreciation of musical rhythms correlates with a premotor activity boost. Human brain mapping 2010 · 10.1002/hbm.20844 |
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| "Differences in ""bottom-up"" and ""top-down"" neural activity in current and former cigarette smokers: Evidence for neu NeuroImage 2011 · 10.1016/j.neuroimage.2011.03.054 |
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| Money talks: neural substrate of modulation of fairness by monetary incentives. Frontiers in behavioral neuroscience 2014 · 10.3389/fnbeh.2014.00150 |
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| Identifying and Mapping Connectivity Patterns of Brain Network Hubs in Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991) 2014 · 10.1093/cercor/bhu246 |
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| Cognitive Deterioration and Functional Compensation in ALS Measured with fMRI Using an Inhibitory Task. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 · 10.1523/JNEUROSCI.1111-14.2014 |
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| Altered dynamics between neural systems sub-serving decisions for unhealthy food. Frontiers in neuroscience 2014 · 10.3389/fnins.2014.00350 |
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| Neurobiological Impact of Nicotinic Acetylcholine Receptor Agonists: An Activation Likelihood Estimation Meta-Analysis o Biological psychiatry 2015 · 10.1016/j.biopsych.2014.12.021 |
| Mirroring pain in the brain: emotional expression versus motor imitation. PloS one 2015 · 10.1371/journal.pone.0107526 |
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| Functional connectivity patterns reflect individual differences in conflict adaptation. Neuropsychologia 2015 · 10.1016/j.neuropsychologia.2015.02.031 |
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| Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measu Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00074 |
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| Love-related changes in the brain: a resting-state functional magnetic resonance imaging study. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00071 |
| Propensity to obesity impacts the neuronal response to energy imbalance. Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00052 |
| Obesity is marked by distinct functional connectivity in brain networks involved in food reward and salience. Behavioural brain research 2015 · 10.1016/j.bbr.2015.03.016 |
| What can the brain teach us about winemaking? An fMRI study of alcohol level preferences. PloS one 2015 · 10.1371/journal.pone.0119220 |
| Do I know you? Examining face and object memory in frontotemporal dementia. Neuropsychologia 2015 · 10.1016/j.neuropsychologia.2015.03.020 |
| A preliminary fMRI study of a novel self-paced written fluency task: observation of left-hemispheric activation, and in Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00113 |
| Hippocampus is place of interaction between unconscious and conscious memories. PloS one 2015 · 10.1371/journal.pone.0122459 |
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| Neural Correlates of Disturbed Emotion Processing in Borderline Personality Disorder: A Multimodal Meta-Analysis. Biological psychiatry 2015 · 10.1016/j.biopsych.2015.03.027 |
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| The neural basis of testable and non-testable beliefs. PloS one 2015 · 10.1371/journal.pone.0124596 |
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| Activity in the brain network for dynamic manipulation of unstable objects is robust to acute tactile nerve block: An fM Brain research 2015 · 10.1016/j.brainres.2015.05.016 |
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| Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study. PloS one 2015 · 10.1371/journal.pone.0128964 |
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| May Functional Imaging be Helpful for Behavioral Assessment in Children? Regions of Motor and Associative Cortico-Subco Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00314 |
| Neural Substrates for Head Movements in Humans: A Functional Magnetic Resonance Imaging Study. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 · 10.1523/JNEUROSCI.0851-15.2015 |
| Individual differences in common factors of emotional traits and executive functions predict functional connectivity of NeuroImage 2015 · 10.1016/j.neuroimage.2015.06.049 |
| Psychosocial versus physiological stress - Meta-analyses on deactivations and activations of the neural correlates of st NeuroImage 2015 · 10.1016/j.neuroimage.2015.06.059 |
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| Neural correlates of biased social fear learning and interaction in an intergroup context. NeuroImage 2015 · 10.1016/j.neuroimage.2015.07.015 |
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| "What letters can ""learn"" from Arabic digits--fMRI-controlled single case therapy study of peripheral agraphia." Brain and language 2015 · 10.1016/j.bandl.2015.06.003 |
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| Modulation of Craving Related Brain Responses Using Real-Time fMRI in Patients with Alcohol Use Disorder. PloS one 2015 · 10.1371/journal.pone.0133034 |
| Probing the Interoceptive Network by Listening to Heartbeats: An fMRI Study. PloS one 2015 · 10.1371/journal.pone.0133164 |
| Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study. Psychiatry research 2015 · 10.1016/j.pscychresns.2015.06.002 |
| Objects Mediate Goal Integration in Ventrolateral Prefrontal Cortex during Action Observation. PloS one 2015 · 10.1371/journal.pone.0134316 |
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| Brain Regions Associated to a Kinesthetic Illusion Evoked by Watching a Video of One's Own Moving Hand. PloS one 2015 · 10.1371/journal.pone.0131970 |
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| Alteration of Basal Ganglia and Right Frontoparietal Network in Early Drug-Naive Parkinson's Disease during Heat Pain S Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00467 |
| The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal. Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00238 |
| Repetition-Related Reductions in Neural Activity during Emotional Simulations of Future Events. PloS one 2015 · 10.1371/journal.pone.0138354 |
| Physical attractiveness and sex as modulatory factors of empathic brain responses to pain. Frontiers in behavioral neuroscience 2015 · 10.3389/fnbeh.2015.00236 |
| Altered connectivity of the dorsal and ventral visual regions in dyslexic children: a resting-state fMRI study. Frontiers in human neuroscience 2015 · 10.3389/fnhum.2015.00495 |
| fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. Frontiers in systems neuroscience 2015 · 10.3389/fnsys.2015.00124 |
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| Neuroanatomical Correlates of Theory of Mind Deficit in Parkinson's Disease: A Multimodal Imaging Study. PloS one 2015 · 10.1371/journal.pone.0142234 |
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| Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in bing PMID 26275334 |
| Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients w PMID 26277269 |
| Brain Regions Associated to a Kinesthetic Illusion Evoked by Watching a Video of One's Own Moving Hand PMID 26287488 |
| Inhibition-Induced Forgetting Results from Resource Competition between Response Inhibition and Memory Encoding Processe PMID 26311775 |
| The relationship between the neural computations for speech and music perception is context-dependent: an activation lik PMID 26321976 |
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| Reading fiction and reading minds: the role of simulation in the default network PMID 26342221 |
| Neurobiological underpinnings of sensation seeking trait in heroin abusers PMID 26364127 |
| The integration of the internal and external milieu in the insula during dynamic emotional experiences PMID 26375211 |
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| Structural and functional connectivity of the subthalamic nucleus during vocal emotion decoding PMID 26400857 |
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| Effects of Body Mass Index and Body Fat Percent on Default Mode, Executive Control, and Salience Network Structure and F PMID 27378831 |
| Neural response to modulating the probability that actions of self or other result in auditory tones: A parametric fMRI PMID 27381929 |
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| Imaging Imageability: Behavioral Effects and Neural Correlates of Its Interaction with Affect and Context PMID 27471455 |
| Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in neg PMID 27474908 |
| Neural Activation during Anticipation of Near Pain-Threshold Stimulation among the Pain-Fearful PMID 27489536 |
| Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait an PMID 27504262 |
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| A Neural Basis for the Acquired Capability for Suicide PMID 27531983 |
| Decreased Activation of Subcortical Brain Areas in the Motor Fatigue State: An fMRI Study PMID 27536264 |
| The role of language in the experience and perception of emotion: a neuroimaging meta-analysis PMID 27539864 |
| Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accide PMID 27547195 |
| Accuracy of automated classification of major depressive disorder as a function of symptom severity PMID 27551669 |
| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Age-related differences in brain activity during implicit and explicit processing of fearful facial expressions PMID 27614138 |
| Default Mode and Executive Networks Areas: Association with the Serial Order in Divergent Thinking PMID 27627760 |
| Brain Responses during the Anticipation of Dyspnea PMID 27648309 |
| Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain’s Response to Fat123 PMID 27655761 |
| CBTreducesCBF: cognitive‐behavioral therapy reduces cerebral blood flow in fear‐relevant brain regions in spider phobia PMID 27688940 |
| Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral tre PMID 27693614 |
| Neural Activities Underlying the Feedback Express Salience Prediction Errors for Appetitive and Aversive Stimuli PMID 27694920 |
| The network substrate of confabulatory tendencies in Alzheimer's disease PMID 27720424 |
| High Frequency Migraine Is Associated with Lower Acute Pain Sensitivity and Abnormal Insula Activity Related to Migraine PMID 27746728 |
| Difference in Activity in the Supplementary Motor Area Depending on Limb Combination of Hand–Foot Coordinated Movements PMID 27757079 |
| Central Pain Processing in Early-Stage Parkinson's Disease: A Laser Pain fMRI Study PMID 27776130 |
| Recruitment of Language-, Emotion- and Speech-Timing Associated Brain Regions for Expressing Emotional Prosody: Investig PMID 27803656 |
| Motor sequence learning-induced neural efficiency in functional brain connectivity PMID 27845228 |
| Prediction of Biological Motion Perception Performance from Intrinsic Brain Network Regional Efficiency PMID 27853427 |
| Putamen Activation Represents an Intrinsic Positive Prediction Error Signal for Visual Search in Repeated Configurations PMID 27867436 |
| Neural Systems Underlying Emotional and Non-emotional Interference Processing: An ALE Meta-Analysis of Functional Neuroi PMID 27895564 |
| A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia PMID 27895619 |
| Experience-dependent modulation of right anterior insula and sensorimotor regions as a function of noise-masked auditory PMID 27916664 |
| Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis PMID 27922089 |
| Recapitulation of emotional source context during memory retrieval PMID 27923474 |
| Sex differences in emotional perception: Meta analysis of divergent activation PMID 27988321 |
| Failure to retreat: Blunted sensitivity to negative feedback supports risky behavior in adolescents PMID 27989774 |
| Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis PMID 27995064 |
| Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study PMID 27995067 |
| Intrinsic inter-network brain dysfunction correlates with symptom dimensions in late-life depression PMID 28017917 |
| Priming Hand Motor Training with Repetitive Stimulation of the Fingertips; Performance Gain and Functional Imaging of Tr PMID 28029594 |
| Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk PMID 28031150 |
| Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disord PMID 28039553 |
| Ipsilateral Putamen and Insula Activation by Both Left and Right GB34 Acupuncture Stimulation: An fMRI Study on Healthy PMID 28053642 |
| Predicting the Multisensory Consequences of One’s Own Action: BOLD Suppression in Auditory and Visual Cortices PMID 28060861 |
| Effects of Intensity of Facial Expressions on Amygdalar Activation Independently of Valence PMID 28066216 |
| Hemispheric asymmetries in the transition from action preparation to execution PMID 28069542 |
| I know I’ve seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity PMID 28073651 |
| Understanding the Goals of Everyday Instrumental Actions Is Primarily Linked to Object, Not Motor-Kinematic, Information PMID 28081175 |
| Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach PMID 28088652 |
| Neural correlates of babyish adult face processing in men PMID 28095312 |
| Resolving the Brainstem Contributions to Attentional Analgesia PMID 28096471 |
| The Functional Integration in the Sensory-Motor System Predicts Aging in Healthy Older Adults PMID 28111548 |
| Orbitofrontal cortex mediates pain inhibition by monetary reward PMID 28119505 |
| Activation of writing-specific brain regions when reading Chinese as a second language. Effects of training modality and PMID 28131811 |
| Theta and high-beta networks for feedback processing: a simultaneous EEG–fMRI study in healthy male subjects PMID 28140398 |
| Brain–behavior relationships in source memory: Effects of age and memory ability PMID 28161030 |
| Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia PMID 28168061 |
| Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients PMID 28180070 |
| Short-term cerebral activity alterations after surgery in patients with unilateral mesial temporal lobe epilepsy associa PMID 28226275 |
| The interaction of emotion and pain in the insula and secondary somatosensory cortex PMID 28259800 |
| The Effects of Acupuncture Stimulation for Brain Activation and Alcohol Abstinence Self-Efficacy: Functional MRI Study PMID 28280514 |
| How does the body representation system develop in the human brain? PMID 28314184 |
| Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity PMID 28322310 |
| Correlates of Social Exclusion in Social Anxiety Disorder: An fMRI study PMID 28325901 |
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| A neural network underlying intentional emotional facial expression in neurodegenerative disease PMID 28373956 |
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| The brain anatomy of attention-deficit/hyperactivity disorder in young adults – a magnetic resonance imaging study PMID 28406942 |
| Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation m PMID 28413706 |
| Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife PMID 28413778 |
| Working Memory after Traumatic Brain Injury: The Neural Basis of Improved Performance with Methylphenidate PMID 28424597 |
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*Insula · Mai atlas of record · 1164 studies · 156 papers on disk*
The insula is the hidden island — a pyramidal lobe folded deep inside the lateral fissure, buried under three opercula, and the cortex where the body's inside becomes feeling. Pain, temperature, visceral sense, taste — mapped here, integrated with emotion, assigned salience.
The insula is a pyramidal hidden lobe folded deep within the lateral (Sylvian) fissure, capped by the frontal, parietal and temporal opercula. Its surface divides into an anterior part — three short gyri — and a posterior part with two long gyri, separated by the central sulcus of the insula, and ringed by the circular sulcus, which separates it from the opercula. Cytoarchitectonically it is agranular/dysgranular allocortex-adjacent: a three-to-five-layer cortex unlike the six-layer neocortex of the lobes.
*— {'source': 'Mai, Majtanik & Paxinos', 'work': 'Atlas of the Human Brain, 4th ed., Academic Press/Elsevier', 'kind': 'atlas', 'locator': 'axial plates, MNI y −43.7…+1.4 mm, 19 plates (labels Ins)'}*
*— {'source': 'Nolte', 'work': 'The Human Brain: An Introduction to Its Functional Anatomy, 7th ed., Elsevier', 'kind': 'textbook', 'locator': 'ch. 34'}*
Interoceptive cortex: the insula maps the body's internal state — pain, temperature, visceral sensation, taste — integrating it with emotion and salience assignment. Anterior insula couples interoception with executive control and awareness; posterior insula carries primary interosensory representation. It is a hub of the salience network, toggling between the default-mode and central-executive networks.
The functional record: interoceptive cortex — the insula maps internal state and couples it to awareness; the anterior insula couples interoception to emotion and subjective feeling. The decoded profile is pain, interoception, insula. The graded matrix carries the salience family: IGT as standard assessor (the somatic-marker reading), oddball as stimulator, facial-emotion as assessor. Its coactivation map is the island's sandwich: circular sulcus (1,479 shared studies), claustrum (1,196), lateral fissure (1,038), putamen (836).
*— {'source': 'Craig', 'work': 'How Do You Feel? An Interoceptive Moment with Your Neurobiological Self, Princeton, 2015', 'locator': 'ch. 2–8', 'kind': 'textbook'}*
*— {'source': 'Menon & Uddin', 'work': 'Saliency, switching, attention and control: a network model of insula function, Brain Struct Funct 2010', 'locator': '214:655–667 · PMC2899886 (full text held)', 'kind': 'paper'}*
The insular sandwich plus the cingulate (776) — the two interoceptive cortices firing as the salience network's core.
Co-activation partners of record: Circular insular sulcus:1479, Claustrum:1196, Lateral fissure:1038, Putamen:836, Cingulate gyrus, anterior:776, Insular cortex:679, Thalamus:603, Claustrum:584.
Insular lesions blunt pain affect and interoceptive awareness; the anterior insula's role in craving, disgust and anxiety completes the picture. Its 156-study dossier is deep for a buried lobe — the insula fires in nearly every affective and salience paradigm.
10.1016/S0006-3223(99)00083-910.1093/cercor/10.6.5521164 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — pain(interoception), insula(anatomy-reference), motor(action-motor), insular(anatomy-reference), somatosensory(method-other), stimulation(method-other), painful(interoception), anterior(anatomy-reference) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Circular insular sulcus:1479, Claustrum:1196, Lateral fissure:1038, Putamen:836 — each name is a dossier stop in this explorer.