Structure. The amygdala is the almond-shaped nuclear complex in the anterior temporal lobe's medial pole, beneath the uncus and ahead of the hippocampus — a dozen nuclei grouped as basolateral (cortical-input), centromedial (output to hypothalamus/brainstem) and cortical-medial (olfactory-chemosensory) divisions; it fuses caudally with the claustrum's tail.
Function. Threat-and-significance evaluation: fear conditioning's essential substrate (lesion cases like S.M. lose fear recognition and conditioning), emotional salience tagging of memories via hippocampal dialogue, and autonomic/endocrine orchestration of the alarm response; bilateral calcification (Urbach–Wiethe) renders fearlessness.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Amygdalar valuation contribution to deck preference. |
| emotional-stroop ↗ | stimulator | primary | standard-scientific | delivery | Emotional distractors drive amygdalar engagement — the effect's affective core. |
| facial-emotion | stimulator | primary | highly-credible | delivery | Amygdalar emotional significance extraction from the face. |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Amygdalar Punishment salience tagging. |
| oddball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| oddball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Salience network of record: the instrument drives this network (its primary members are |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic network of record: the instrument drives this network (its primary members are C |
| reward-punishment ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-prediction ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| igt ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Reward system (mesocorticolimbic) of record: the paradigm engages this system (its core |
| emotional-stroop ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| facial-emotion | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| pain-induction | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | stimulator | secondary | standard-scientific | delivery | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| cyberball ↗ | assessor | secondary | standard-scientific | fMRI | Co-engaged through the Limbic system of record: the paradigm engages this system (its core members are graded |
| emotional-stroop ↗ | inhibitor | secondary | standard-scientific | delivery | Attentional load suppresses the amygdala's response to threat: a six-letter identification task superimposed o |
| facial-emotion | inhibitor | secondary | standard-scientific | delivery | Backward pattern masking suppresses the amygdala's fear response: BOLD signal decreased to pattern-masked fear |
| face-identity | inhibitor | secondary | standard-scientific | delivery | Repeating one facial identity at constant emotion attenuates the amygdala response: in the factorial identity- |
| oddball ↗ | inhibitor | secondary | standard-scientific | delivery | Stimulus repetition suppresses the amygdala novelty response: snakes and flowers evoked more anatomical amygda |
| pain-induction | inhibitor | secondary | standard-scientific | delivery | Painful knee stimulation activated left amygdala (-20, -6, -18) in osteoarthritis patients before treatment; a |
Experiences of record: Breath-anchor down-regulation · Bias retuning (emotional Stroop)
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| Shared neural resources between left and right interlimb coordination skills: the neural substrate of abstract motor rep NeuroImage 2010 · 10.1016/j.neuroimage.2009.10.052 |
| Comprehension of degraded speech sounds with m-sequence modulation: an fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2009.10.063 |
| Baseline brain perfusion and the serotonin transporter promoter polymorphism. Biological psychiatry 2010 · 10.1016/j.biopsych.2009.08.035 |
| Single domain amnestic MCI: a multiple cognitive domains fMRI investigation. Neurobiology of aging 2011 · 10.1016/j.neurobiolaging.2009.09.006 |
| Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Al Cerebral cortex (New York, N.Y. : 1991) 2010 · 10.1093/cercor/bhp232 |
| Object familiarity modulates the relationship between visual object imagery and haptic shape perception. NeuroImage 2010 · 10.1016/j.neuroimage.2009.10.081 |
| Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli. Human brain mapping 2010 · 10.1002/hbm.20900 |
| Cerebral and cerebrospinal processes underlying counterirritation analgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 · 10.1523/JNEUROSCI.2341-09.2009 |
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| Virus and epidemic: causal knowledge activates prediction error circuitry. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2009.21387 |
| Neural mechanisms of context effects on face recognition: automatic binding and context shift decrements. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2009.21379 |
| Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2009.21394 |
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| Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 · 10.1523/JNEUROSCI.3609-09.2009 |
| Neural long-term effects of emotion regulation on episodic memory processes. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2009.11.022 |
| Anomalous neural circuit function in schizophrenia during a virtual Morris water task. NeuroImage 2010 · 10.1016/j.neuroimage.2009.11.034 |
| The neural correlates of sex differences in emotional reactivity and emotion regulation. Human brain mapping 2010 · 10.1002/hbm.20903 |
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| Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biological psychiatry 2010 · 10.1016/j.biopsych.2009.10.020 |
| Effects of aging on default mode network activity in resting state fMRI: does the method of analysis matter? NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.008 |
| Behavioral, neuroimaging, and computational evidence for perceptual caching in repetition priming. Brain research 2010 · 10.1016/j.brainres.2009.11.074 |
| The effect of G72 genotype on neural correlates of memory encoding and retrieval. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.018 |
| Recollection versus strength as the primary determinant of hippocampal engagement at retrieval. Proceedings of the National Academy of Sciences of the United States of America 2009 · 10.1073/pnas.0908651106 |
| Age-effects on associative object-location memory. Brain research 2010 · 10.1016/j.brainres.2009.12.011 |
| Power spectrum scale invariance quantifies limbic dysregulation in trait anxious adults using fMRI: adapting methods op NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.021 |
| Neural representation of subjective value under risk and ambiguity. Journal of neurophysiology 2010 · 10.1152/jn.00853.2009 |
| Distinct representations of phonemes, syllables, and supra-syllabic sequences in the speech production network. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.065 |
| The functional organisation of the fronto-temporal language system: evidence from syntactic and semantic ambiguity. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2009.12.035 |
| Insula and orbital frontal cortex activity underlying emotion interference resolution in working memory. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2010.21428 |
| A unique role for the human amygdala in novelty detection. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.083 |
| The neural correlates of implicit and explicit self-relevant processing. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.098 |
| Neural processing of negative word stimuli concerning body image in patients with eating disorders: an fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.095 |
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| When I think about me and simulate you: medial rostral prefrontal cortex and self-referential processes. NeuroImage 2010 · 10.1016/j.neuroimage.2009.12.091 |
| Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal are Biological psychiatry 2010 · 10.1016/j.biopsych.2009.11.017 |
| Chronic effects of cannabis use on the human reward system: an fMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010 · 10.1016/j.euroneuro.2009.11.010 |
| Increased amygdala and parahippocampal gyrus activation in schizophrenic patients with auditory hallucinations: an fMRI Schizophrenia research 2010 · 10.1016/j.schres.2009.12.028 |
| Sex differences in stress response circuitry activation dependent on female hormonal cycle. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3021-09.2010 |
| The contribution of mesiofrontal cortex to the preparation and execution of repetitive syllable productions: an fMRI stu NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.039 |
| Retest reliability of reward-related BOLD signals. NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.036 |
| Amygdala integrates emotional expression and gaze direction in response to dynamic facial expressions. NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.049 |
| The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salie NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.058 |
| The brain's relevance detection network operates independently of stimulus modality. Behavioural brain research 2010 · 10.1016/j.bbr.2010.01.038 |
| The spatial and temporal dynamics of anticipatory preparation and response inhibition in task-switching. NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.090 |
| The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-c NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.094 |
| Emotional imagery: assessing pleasure and arousal in the brain's reward circuitry. Human brain mapping 2010 · 10.1002/hbm.20948 |
| COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. NeuroImage 2010 · 10.1016/j.neuroimage.2010.01.084 |
| Behavioral activation system modulation on brain activation during appetitive and aversive stimulus processing. Social cognitive and affective neuroscience 2010 · 10.1093/scan/nsq012 |
| Similar cerebral networks in language, music and song perception. NeuroImage 2010 · 10.1016/j.neuroimage.2010.02.023 |
| Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain : a journal of neurology 2010 · 10.1093/brain/awq006 |
| Differential effects of semantic processing on memory encoding. Human brain mapping 2010 · 10.1002/hbm.20969 |
| Primary and secondary rewards differentially modulate neural activity dynamics during working memory. PloS one 2010 · 10.1371/journal.pone.0009251 |
| Women with a history of childhood maltreatment exhibit more activation in association areas following non-traumatic olfa PloS one 2010 · 10.1371/journal.pone.0009362 |
| The changing face of emotion: age-related patterns of amygdala activation to salient faces. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq007 |
| Hippocampal contribution to early and later stages of implicit motor sequence learning. Experimental brain research 2010 · 10.1007/s00221-010-2186-6 |
| Emotional complexity and the neural representation of emotion in motion. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq021 |
| Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq017 |
| fMRI study of mesial temporal lobe epilepsy using amplitude of low-frequency fluctuation analysis. Human brain mapping 2010 · 10.1002/hbm.20982 |
| Mental representations of action: the neural correlates of the verbal and motor components. Brain research 2010 · 10.1016/j.brainres.2010.02.082 |
| Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. Biological psychology 2010 · 10.1016/j.biopsycho.2010.03.005 |
| Cerebral asymmetries: complementary and independent processes. PloS one 2010 · 10.1371/journal.pone.0009682 |
| Altered parahippocampal functioning in cannabis users is related to the frequency of use. Psychopharmacology 2010 · 10.1007/s00213-010-1805-z |
| Prosodic and narrative processing in American Sign Language: an fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2010.03.055 |
| Beyond the memory mechanism: person-selective and nonselective processes in recognition of personally familiar faces. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21469 |
| Self-esteem modulates medial prefrontal cortical responses to evaluative social feedback. Cerebral cortex (New York, N.Y. : 1991) 2010 · 10.1093/cercor/bhq049 |
| "The ""visual word form area"" is involved in successful memory encoding of both words and faces." NeuroImage 2010 · 10.1016/j.neuroimage.2010.03.067 |
| Regional homogeneity of fMRI time series in autism spectrum disorders. Neuroscience letters 2010 · 10.1016/j.neulet.2010.03.080 |
| Hippocampal activation during retrieval of spatial context from episodic and semantic memory. Behavioural brain research 2010 · 10.1016/j.bbr.2010.04.010 |
| How instructions modify perception: an fMRI study investigating brain areas involved in attributing human agency. NeuroImage 2010 · 10.1016/j.neuroimage.2010.04.025 |
| Neural mechanism of unconscious perception of surprised facial expression. NeuroImage 2010 · 10.1016/j.neuroimage.2010.04.021 |
| Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in childre Biological psychiatry 2010 · 10.1016/j.biopsych.2010.02.020 |
| Dissection of perceptual, motor and autonomic components of brain activity evoked by noxious stimulation. Pain 2010 · 10.1016/j.pain.2010.01.005 |
| Dissociating the neural correlates of intra-item and inter-item working-memory binding. PloS one 2010 · 10.1371/journal.pone.0010214 |
| fMRI responses to words repeated in a congruous semantic context are abnormal in mild Alzheimer's disease. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.04.021 |
| A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression a NeuroImage 2011 · 10.1016/j.neuroimage.2010.04.269 |
| Effects of aging on mindreading ability through the eyes: an fMRI study. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.05.005 |
| Stop looking angry and smile, please: start and stop of the very same facial expression differentially activate threat- Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq039 |
| Age-related functional changes in gustatory and reward processing regions: An fMRI study. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.012 |
| Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.4899-09.2010 |
| Increased amygdala activation during automatic processing of facial emotion in schizophrenia. Psychiatry research 2010 · 10.1016/j.pscychresns.2010.03.005 |
| Gender differences in brain activation during encoding and recognition of male and female faces. Brain imaging and behavior 2010 · 10.1007/s11682-009-9085-0 |
| Amygdala engagement in response to subthreshold presentations of anxious face stimuli in adults with autism spectrum dis PloS one 2010 · 10.1371/journal.pone.0010804 |
| Sleep leads to changes in the emotional memory trace: evidence from FMRI. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21526 |
| Watching my mind unfold versus yours: an fMRI study using a novel camera technology to examine neural differences in sel Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21518 |
| Structural and functional bases for individual differences in motor learning. Human brain mapping 2011 · 10.1002/hbm.21037 |
| Affect regulation and pain in borderline personality disorder: a possible link to the understanding of self-injury. Biological psychiatry 2010 · 10.1016/j.biopsych.2010.04.015 |
| Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease. Neurobiology of aging 2012 · 10.1016/j.neurobiolaging.2010.04.013 |
| The effect of arousal on the emotional memory network depends on valence. NeuroImage 2010 · 10.1016/j.neuroimage.2010.06.015 |
| Neural mechanisms for voice recognition. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.048 |
| Neural correlates of intolerance of uncertainty. Neuroscience letters 2010 · 10.1016/j.neulet.2010.05.078 |
| A virtual reality-based FMRI study of reward-based spatial learning. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.05.033 |
| Autobiographical memory retrieval in patients with Alzheimer's disease. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.082 |
| Animated brain: a functional neuroimaging study on animacy experience. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.080 |
| Exaggerated and disconnected insular-amygdalar blood oxygenation level-dependent response to threat-related emotional f Biological psychiatry 2010 · 10.1016/j.biopsych.2010.04.028 |
| Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Human brain mapping 2011 · 10.1002/hbm.21081 |
| The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2011 · 10.1016/j.euroneuro.2010.06.008 |
| Cerebral asymmetries in monozygotic twins: an fMRI study. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.06.020 |
| Amygdala involvement in human avoidance, escape and approach behavior. NeuroImage 2010 · 10.1016/j.neuroimage.2010.06.058 |
| Error detection in the stop signal task. NeuroImage 2010 · 10.1016/j.neuroimage.2010.06.056 |
| Electrical source dynamics in three functional localizer paradigms. NeuroImage 2010 · 10.1016/j.neuroimage.2010.06.037 |
| Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.5516-09.2010 |
| Investigation of acupoint specificity by functional connectivity analysis based on graph theory. Neuroscience letters 2010 · 10.1016/j.neulet.2010.06.091 |
| Fear thou not: activity of frontal and temporal circuits in moments of real-life courage. Neuron 2010 · 10.1016/j.neuron.2010.06.009 |
| Enhanced resting-state connectivity of amygdala in the immediate aftermath of acute psychological stress. NeuroImage 2010 · 10.1016/j.neuroimage.2010.05.070 |
| Top-down modulations in the visual form pathway revealed with dynamic causal modeling. Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq122 |
| An fMRI study of sentence-embedded lexical-semantic decision in children and adults. Brain and language 2010 · 10.1016/j.bandl.2010.03.009 |
| Developmental differences in medial temporal lobe function during memory encoding. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3500-09.2010 |
| Menstrual cycle modulation of medial temporal activity evoked by negative emotion. NeuroImage 2010 · 10.1016/j.neuroimage.2010.07.011 |
| A dual-route perspective on poor reading in a regular orthography: an fMRI study. Cortex; a journal devoted to the study of the nervous system and behavior 2010 · 10.1016/j.cortex.2010.06.004 |
| Remembering beauty: roles of orbitofrontal and hippocampal regions in successful memory encoding of attractive faces. NeuroImage 2011 · 10.1016/j.neuroimage.2010.07.046 |
| Sustained amygdala response to both novel and newly familiar faces characterizes inhibited temperament. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq073 |
| The supraspinal neural correlate of bladder cold sensation--an fMRI study. Human brain mapping 2011 · 10.1002/hbm.21070 |
| Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human brain mapping 2011 · 10.1002/hbm.21102 |
| Weaving the (neuronal) web: fear learning in spider phobia. NeuroImage 2011 · 10.1016/j.neuroimage.2010.07.049 |
| Perceptual organization and visual search processes during target detection task performance in schizophrenia, as revea Neuropsychologia 2010 · 10.1016/j.schres.2009.12.014 |
| The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia. Psychiatry research 2010 · 10.1016/j.pscychresns.2010.03.007 |
| In vivo brain anatomy of adult males with Fragile X syndrome: an MRI study. NeuroImage 2011 · 10.1016/j.neuroimage.2010.08.015 |
| Olfactory deficit detected by fMRI in early Alzheimer's disease. Brain research 2010 · 10.1016/j.brainres.2010.08.018 |
| A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? PloS one 2010 · 10.1371/journal.pone.0012073 |
| Similarities and differences in perceiving threat from dynamic faces and bodies. An fMRI study. NeuroImage 2011 · 10.1016/j.neuroimage.2010.08.012 |
| Implicit sequence-specific motor learning after subcortical stroke is associated with increased prefrontal brain activa Human brain mapping 2011 · 10.1002/hbm.21019 |
| Investigating brain response to music: a comparison of different fMRI acquisition schemes. NeuroImage 2011 · 10.1016/j.neuroimage.2010.08.029 |
| Functional relations of empathy and mentalizing: an fMRI study on the neural basis of cognitive empathy. NeuroImage 2011 · 10.1016/j.neuroimage.2010.08.024 |
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| Emotion speeds up conflict resolution: a new role for the ventral anterior cingulate cortex? Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq157 |
| Equivalent activation of the hippocampus by face-face and face-laugh paired associate learning and recognition. Neuropsychologia 2010 · 10.1016/j.neuropsychologia.2010.08.018 |
| Autistic disorders and schizophrenia: related or remote? An anatomical likelihood estimation. PloS one 2010 · 10.1371/journal.pone.0012233 |
| Dietary restraint violations influence reward responses in nucleus accumbens and amygdala. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21568 |
| Establishing the boundaries: the hippocampal contribution to imagining scenes. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.0723-10.2010 |
| Changes in functioning of mesolimbic incentive processing circuits during the premenstrual phase. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq071 |
| Localized gray matter volume abnormalities in generalized anxiety disorder. European archives of psychiatry and clinical neuroscience 2011 · 10.1007/s00406-010-0147-5 |
| Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. Brain : a journal of neurology 2010 · 10.1093/brain/awq229 |
| Dissociable contributions of prefrontal cortex and the hippocampus to short-term memory: evidence for a 3-state model o NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.002 |
| Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a disti NeuroImage 2011 · 10.1016/j.neuroimage.2010.08.082 |
| Memory related dysregulation of hippocampal function in major depressive disorder. Biological psychology 2010 · 10.1016/j.biopsycho.2010.09.002 |
| Adolescent resting state networks and their associations with schizotypal trait expression. Frontiers in systems neuroscience 2010 · 10.3389/fnsys.2010.00035 |
| Parsing decision making processes in prefrontal cortex: response inhibition, overcoming learned avoidance, and reversal NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.017 |
| Time-dependent effects of corticosteroids on human amygdala processing. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3112-10.2010 |
| Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study. NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.048 |
| Reorganization of functional and effective connectivity during real-time fMRI-BCI modulation of prosody processing. Brain and language 2011 · 10.1016/j.bandl.2010.07.008 |
| Neural correlates of task switching in paternal 15q11-q13 deletion Prader-Willi syndrome. Brain research 2010 · 10.1016/j.brainres.2010.09.093 |
| Effect of menstrual cycle phase on corticolimbic brain activation by visual food cues. Brain research 2010 · 10.1016/j.brainres.2010.09.071 |
| Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: an fMRI study of panic disorder Psychiatry research 2010 · 10.1016/j.pscychresns.2010.06.005 |
| Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Frontiers in systems neuroscience 2010 · 10.3389/fnsys.2010.00041 |
| Dissociable neural systems supporting knowledge about human character and appearance in ourselves and others. Journal of cognitive neuroscience 2011 · 10.1162/jocn.2010.21580 |
| Cognitive versus automatic mechanisms of mood induction differentially activate left and right amygdala. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.013 |
| Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.014 |
| Impact of transient emotions on functional connectivity during subsequent resting state: a wavelet correlation approach. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.021 |
| Dissociable brain mechanisms for processing social exclusion and rule violation. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.049 |
| Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociatio The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.3323-10.2010 |
| Amygdala and dorsomedial prefrontal cortex responses to appearance-based and behavior-based person impressions. Social cognitive and affective neuroscience 2011 · 10.1093/scan/nsq086 |
| Prediction of subsequent recognition performance using brain activity in the medial temporal lobe. NeuroImage 2011 · 10.1016/j.neuroimage.2010.10.066 |
| How to regulate emotion? Neural networks for reappraisal and distraction. Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhq216 |
| Individual differences in the neural basis of causal inferencing. Brain and language 2011 · 10.1016/j.bandl.2010.08.004 |
| A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Z Pain 2011 · 10.1016/j.pain.2010.10.006 |
| Evidence for a general face salience signal in human amygdala. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.024 |
| Brain Activations to Emotional Pictures are Differentially Associated with Valence and Arousal Ratings. Frontiers in human neuroscience 2010 · 10.3389/fnhum.2010.00175 |
| Acute and sustained effects of cognitive emotion regulation in major depression. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.1856-10.2010 |
| Regional homogeneity of the resting-state brain activity correlates with individual intelligence. Neuroscience letters 2011 · 10.1016/j.neulet.2010.11.046 |
| Phasic and sustained fear in humans elicits distinct patterns of brain activity. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.057 |
| Art for reward's sake: visual art recruits the ventral striatum. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.027 |
| The neural basis of visual dominance in the context of audio-visual object processing. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.051 |
| Effects of alcohol on brain responses to social signals of threat in humans. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.062 |
| Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.2590-10.2010 |
| Brain dysfunctions during facial discrimination in schizophrenia: selective association to affect decoding. Psychiatry research 2011 · 10.1016/j.pscychresns.2010.09.005 |
| Stimulus content and the neural correlates of source memory. Brain research 2011 · 10.1016/j.brainres.2010.11.086 |
| Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy. Brain research 2011 · 10.1016/j.brainres.2010.12.004 |
| Sex differences in neural responses to stress and alcohol context cues. Human brain mapping 2011 · 10.1002/hbm.21165 |
| ADHD related behaviors are associated with brain activation in the reward system. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2010.12.012 |
| Abnormal cortical activity in patients with temporomandibular disorder evoked by cognitive and emotional tasks. Pain 2011 · 10.1016/j.pain.2010.10.046 |
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| Effects of problem size and arithmetic operation on brain activation during calculation in children with varying levels NeuroImage 2011 · 10.1016/j.neuroimage.2010.12.037 |
| How does your own knowledge influence the perception of another person's action in the human brain? Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsq102 |
| Emotional modulation of the attentional blink: the neural structures involved in capturing and holding attention. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2010.12.037 |
| Subchronic duloxetine administration alters the extended amygdala circuitry in healthy individuals. NeuroImage 2011 · 10.1016/j.neuroimage.2010.12.051 |
| Neuronal correlates of cognitive reappraisal in borderline patients with affective instability. Biological psychiatry 2011 · 10.1016/j.biopsych.2010.10.025 |
| Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning st Pain 2011 · 10.1016/j.pain.2010.11.018 |
| Neural correlates of long-term intense romantic love. Social cognitive and affective neuroscience 2012 · 10.1093/scan/nsq092 |
| Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networks. NeuroImage 2011 · 10.1016/j.neuroimage.2010.12.060 |
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| Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants. Human brain mapping 2011 · 10.1002/hbm.21017 |
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| Comprehending expository texts: the dynamic neurobiological correlates of building a coherent text representation. Frontiers in human neuroscience 2013 · 10.3389/fnhum.2013.00853 |
| Dissociable influences of skewness and valence on economic choice and neural activity. PloS one 2013 · 10.1371/journal.pone.0083454 |
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| Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Pa Biological psychiatry 2014 · 10.1016/j.biopsych.2014.01.016 |
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| Neural control of vascular reactions: impact of emotion and attention. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 · 10.1523/JNEUROSCI.0747-13.2014 |
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| Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues. The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 · 10.1523/JNEUROSCI.4977-13.2014 |
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| Dissociative part-dependent resting-state activity in dissociative identity disorder: a controlled FMRI perfusion study. PloS one 2014 · 10.1371/journal.pone.0098795 |
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| Functional neural changes associated with acquired amusia across different stages of recovery after stroke PMID 28900231 |
| Neural correlates of ambient thermal sensation: An fMRI study PMID 28900235 |
*Limbic lobe & medial ring · Mai atlas of record · 1781 studies · 249 papers on disk*
Every alarm you have ever felt passed through this almond. The left amygdala is the limbic ring's salience registrar: it decides what the rest of the brain should remember being afraid of, and its dialogue with the hippocampus is why emotional events outlive neutral ones in memory.
The amygdala is the almond-shaped nuclear complex in the anterior temporal lobe's medial pole, beneath the uncus and ahead of the hippocampus — a dozen nuclei grouped as basolateral (cortical-input), centromedial (output to hypothalamus/brainstem) and cortical-medial (olfactory-chemosensory) divisions; it fuses caudally with the claustrum's tail.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'medial temporal lobe, amygdala'}*
Threat-and-significance evaluation: fear conditioning's essential substrate (lesion cases like S.M. lose fear recognition and conditioning), emotional salience tagging of memories via hippocampal dialogue, and autonomic/endocrine orchestration of the alarm response; bilateral calcification (Urbach–Wiethe) renders fearlessness.
Read the profile and the shape is unmistakable — the decoded vocabulary here is fear, emotion, faces, threat, reward: this is threat-and-significance evaluation. The functional record makes it concrete: patient S.M., whose amygdalae calcified (Urbach–Wiethe), cannot recognize or condition fear; the rest of cognition runs intact. That dissociation is the amygdala's signature — remove it and danger loses its meaning while the world stays visually unchanged.
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 10, Emotion'}*
The coactivation map reads like an anatomy lesson in feeling: uncus (2,258 shared studies), entorhinal cortex (2,190), rhinal sulcus (1,820) — the amygdala sits inside the olfactory-hippocampal corridor, which is why a smell can trigger dread before you consciously recognize the source. The hippocampal dialogue (883) is the memory-tagging channel.
Co-activation partners of record: Uncus:2258, Entorhinal cortex:2190, Amygdala:2014, Rhinal sulcus:1820, Hippocampus:883, Hippocampal fissure:756, Hippocampus:739, Parahippocampal gyrus:670.
The failure mode is documented in rare human lesions: fearlessness, impaired fear recognition, flattened conditioning — and, from the over-active side, the intrusive alarm of post-traumatic hypervigilance. The graded matrix records facial-emotion paradigms as highly-credible stimulators of this region, with the emotional Stroop as a standard assessor.
10.1016/S0896-6273(00)80475-410.1016/S0896-6273(00)80715-110.1093/brain/122.5.9431781 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — amygdala(anatomy-reference), emotional(emotion), faces(perception), emotion(emotion), neutral(emotion), hippocampus(anatomy-reference), fear(emotion), reward(method-other) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Uncus:2258, Entorhinal cortex:2190, Amygdala:2014, Rhinal sulcus:1820 — each name is a dossier stop in this explorer.