Structure. The external segment of the globus pallidus is the lentiform complex's pale medial companion plate, split from the internal segment by the medial medullary lamina; it is the indirect pathway's central relay, linked to the subthalamic nucleus by the subthalamic fascicle.
Function. The brake-amplifier of action selection: GABAergic pallidosubthalamic inhibition lets the subthalamic nucleus excite output nuclei — the indirect path's tonic-suppression loop. Its disinhibition (lesion or stimulation) quiets the ballism/dystonic overflow that loss of subthalamic control produces.
| Instrument | Role | Tier | Credibility | Via | Observed effect |
|---|---|---|---|---|---|
| stopsignal ↗ | assessor | secondary | standard-scientific | fMRI | In an fMRI stop-signal task, response-phase activity in left globus pallidus correlated with stop accuracy (r2 |
| pain-induction | assessor | secondary | standard-scientific | fMRI | During thermal noxious stimulation under a placebo-analgesia fMRI protocol, late-phase pain activation was rep |
| gonogo ↗ | assessor | secondary | standard-scientific | fMRI | Acute cannabis and cocaine raised cognitive impulsivity (Matching Familiar Figures Test) and reduced nucleus a |
| reward-prediction ↗ | assessor | secondary | standard-scientific | fMRI | ALE meta-analysis of reward fMRI lists left lateral globus pallidus (GPe) among reward-anticipation substrates |
| reward-punishment ↗ | assessor | secondary | standard-scientific | fMRI | Transdiagnostic ALE meta-analysis ties consummatory anhedonia in MDD and schizophrenia to decreased ventral ba |
| igt ↗ | assessor | secondary | standard-scientific | fMRI | Adolescents weighing risky vs cautious monetary choices (win 5 cents/lose 10 cents) showed between-group activ |
| stroop ↗ | stimulator | secondary | standard-scientific | delivery | Modified response-conflict fMRI (categorize houses/buildings with congruent/incongruent overlaid words) under |
| nback ↗ | stimulator | secondary | standard-scientific | delivery | Cued working-memory filtering fMRI (delayed match-to-sample with distractor-predictive cues): high > low WM lo |
| taskswitching ↗ | stimulator | secondary | standard-scientific | delivery | Attention-switching fMRI (verbal/visuospatial WM under switching demands): switching engaged left thalamus and |
| simple-rt ↗ | stimulator | secondary | standard-scientific | delivery | ALE meta-analysis of audiomotor entrainment: the basal ganglia (left putamen; left globus pallidus ALE peak -1 |
| emotional-stroop ↗ | stimulator | secondary | standard-scientific | delivery | 7T picture-anticipation fMRI: anticipation of erotic versus emotional pictures increased activation in the lef |
| reward-prediction ↗ | inhibitor | secondary | standard-scientific | delivery | Task-induced deactivation: in the reward-cue response-conflict study, left lateral globus pallidum showed grea |
| sentence-comprehension | inhibitor | secondary | standard-scientific | delivery | Miniature-German acquisition fMRI: participants repeatedly listened to sentences with novel words and a novel |
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| Feedback signals in the caudate reflect goal achievement on a declarative memory task. NeuroImage 2008 · 10.1016/j.neuroimage.2008.02.066 |
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| Anticipatory activity in anterior cingulate cortex can be independent of conflict and error likelihood. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 · 10.1523/JNEUROSCI.4400-07.2008 |
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| Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 · 10.1523/JNEUROSCI.0910-08.2008 |
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| Negation in the brain: modulating action representations. NeuroImage 2008 · 10.1016/j.neuroimage.2008.08.004 |
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| Recognizing threat: a simple geometric shape activates neural circuitry for threat detection. Journal of cognitive neuroscience 2009 · 10.1162/jocn.2009.21111 |
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| Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers Cortex; a journal devoted to the study of the nervous system and behavior 2010 · 10.1016/j.cortex.2009.02.017 |
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| Specific and nonspecific neural activity during selective processing of visual representations in working memory. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2009.21250 |
| Bending the rules: strategic behavioral differences are reflected in the brain. Journal of cognitive neuroscience 2010 · 10.1162/jocn.2009.21245 |
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| fMRI effects of task demand and feedback accuracy on grip force tracking. Neuroscience letters 2009 · 10.1016/j.neulet.2009.04.013 |
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| Compensatory mechanisms underlie intact task-switching performance in schizophrenia. Neuropsychologia 2010 · 10.1111/j.1469-8986.2009.00932.x |
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| Mental hoop diaries: emotional memories of a college basketball game in rival fans. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 · 10.1523/JNEUROSCI.2481-09.2010 |
| Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain : a journal of neurology 2010 · 10.1093/brain/awq006 |
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| Neural mechanisms involved in the oral representation of percussion music: an fMRI study. Brain and cognition 2010 · 10.1016/j.bandc.2010.07.008 |
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| Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation. NeuroImage 2011 · 10.1016/j.neuroimage.2010.09.012 |
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| Functional neural networks of time perception: challenge and opportunity for schizophrenia research. Schizophrenia research 2011 · 10.1016/j.schres.2010.10.003 |
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| D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans. NeuroImage 2011 · 10.1016/j.neuroimage.2010.11.034 |
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| How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia. NeuroImage 2011 · 10.1016/j.neuroimage.2011.02.015 |
| Glucose administration enhances fMRI brain activation and connectivity related to episodic memory encoding for neutral a Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.02.013 |
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| Differential contributions of bilateral ventral anterior temporal lobe and left anterior superior temporal gyrus to sema Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00007 |
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| Brain mechanisms of perceiving tools and imagining tool use acts: a functional MRI study. Neuropsychologia 2011 · 10.1016/j.neuropsychologia.2011.03.010 |
| Multimodal imaging of functional networks and event-related potentials in performance monitoring. NeuroImage 2011 · 10.1016/j.neuroimage.2011.03.039 |
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| Is morality unified? Evidence that distinct neural systems underlie moral judgments of harm, dishonesty, and disgust. Journal of cognitive neuroscience 2011 · 10.1162/jocn_a_00017 |
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| Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: a functional MRI study. Journal of the neurological sciences 2011 · 10.1016/j.jns.2011.03.040 |
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| Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 · 10.1523/JNEUROSCI.5980-10.2011 |
| Functional and dysfunctional brain circuits underlying emotional processing of music in autism spectrum disorders. Cerebral cortex (New York, N.Y. : 1991) 2011 · 10.1093/cercor/bhr084 |
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| How cognitive performance-induced stress can influence right VLPFC activation: an fMRI study in healthy subjects and in Human brain mapping 2012 · 10.1002/hbm.21340 |
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| Representation of perceived sound valence in the human brain. Human brain mapping 2012 · 10.1002/hbm.21362 |
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| The centre of the brain: topographical model of motor, cognitive, affective, and somatosensory functions of the basal g Human brain mapping 2013 · 10.1002/hbm.22124 |
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| Gustatory perception alterations in obesity: an fMRI study. Brain research 2012 · 10.1016/j.brainres.2012.07.051 |
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| The neural correlates of cognitive reappraisal during emotional autobiographical memory recall. Journal of cognitive neuroscience 2013 · 10.1162/jocn_a_00289 |
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| High-frequency TRNS reduces BOLD activity during visuomotor learning. PloS one 2013 · 10.1371/journal.pone.0059669 |
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| Neural correlates of Machiavellian strategies in a social dilemma task. Brain and cognition 2013 · 10.1016/j.bandc.2013.02.012 |
| Complexity in Relational Processing Predicts Changes in Functional Brain Network Dynamics. Cerebral cortex (New York, N.Y. : 1991) 2013 · 10.1093/cercor/bht075 |
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| The Role of the Insular Cortex in Retaliation PMID 27096431 |
| Resting-state fMRI reveals potential neural correlates of impaired cognition in Huntington's disease PMID 27117563 |
| Neural activity related to discrimination and vocal production of consonant and dissonant musical intervals PMID 27134038 |
| Cortisol alters reward processing in the human brain PMID 27170428 |
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| Neural mechanisms of goal-contingent task disengagement: Response-irrelevant stimuli activate the default mode network PMID 27253724 |
| Perceptual demand and distraction interactions mediated by task-control networks PMID 27261159 |
| Effects of progressive muscle relaxation on cerebral activity: An fMRI investigation PMID 27261979 |
| Neural Processing of Emotional Musical and Nonmusical Stimuli in Depression PMID 27284693 |
| Brain activation profiles during kinesthetic and visual imagery: An fMRI study PMID 27288703 |
| Behavioural and neuroimaging changes after naming therapy for semantic variant primary progressive aphasia PMID 27297727 |
| Effects of aging on task- and stimulus-related cerebral attention networks PMID 27318136 |
| Regional homogeneity changes in amnestic mild cognitive impairment patients PMID 27345927 |
| Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of vio PMID 27366072 |
| Decreased neural response for facial emotion processing in subjects with high genetic load for schizophrenia PMID 27375133 |
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| Atypical within- and between-hemisphere motor network functional connections in children with developmental coordination PMID 27419066 |
| Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors PMID 27429808 |
| Exploring the Neural Representation of Novel Words Learned through Enactment in a Word Recognition Task PMID 27445918 |
| The Neural Substrates Underlying the Implementation of Phonological Rule in Lexical Tone Production: An fMRI Study of th PMID 27455078 |
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| Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in neg PMID 27474908 |
| Tinnitus- related distress: evidence from fMRI of an emotional stroop task PMID 27499700 |
| Brain networks of temporal preparation: A multiple regression analysis of neuropsychological data PMID 27521744 |
| A Neural Basis for the Acquired Capability for Suicide PMID 27531983 |
| Decreased Activation of Subcortical Brain Areas in the Motor Fatigue State: An fMRI Study PMID 27536264 |
| The role of language in the experience and perception of emotion: a neuroimaging meta-analysis PMID 27539864 |
| Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/o PMID 27546352 |
| A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease PMID 27565302 |
| Retrieved emotional context influences hippocampal involvement during recognition of neutral memories PMID 27592810 |
| Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing PMID 27600852 |
| Parametric modulation of reward sequences during a reversal task in ACC and VMPFC but not amygdala and striatum PMID 27622399 |
| Altered reward expectancy in individuals with recent methamphetamine dependence PMID 27649775 |
| Distributed patterns of occipito-parietal functional connectivity predict the precision of visual working memory PMID 27721028 |
| Evaluation of Handwriting Movement Kinematics: From an Ecological to a Magnetic Resonance Environment PMID 27746727 |
| The Neural Bases of Disgust for Cheese: An fMRI Study PMID 27799903 |
| An Activation Likelihood Estimation Meta-Analysis Study of Simple Motor Movements in Older and Young Adults PMID 27799910 |
| Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain PMID 27841974 |
| Motor sequence learning-induced neural efficiency in functional brain connectivity PMID 27845228 |
| Somatic and Reinforcement-Based Plasticity in the Initial Stages of Human Motor Learning PMID 27852776 |
| Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease PMID 27857211 |
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*Frontal lobe · Mai atlas of record · 1173 studies · 149 papers on disk*
The external pallidum is the brake-amplifier of action selection — the indirect pathway's tonic suppression loop. GABAergic pallidosubthalamic inhibition lets the subthalamic nucleus drive the output nuclei harder: the brain's standing way of making the next unwanted action harder to launch.
The external segment of the globus pallidus is the lentiform complex's pale medial companion plate, split from the internal segment by the medial medullary lamina; it is the indirect pathway's central relay, linked to the subthalamic nucleus by the subthalamic fascicle.
*— {'source': 'Naidich, Duvernoy, Delman, Sorensen, Kollias & Haacke', 'work': "Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Springer", 'kind': 'atlas', 'locator': 'basal ganglia, internal structure'}*
The brake-amplifier of action selection: GABAergic pallidosubthalamic inhibition lets the subthalamic nucleus excite output nuclei — the indirect path's tonic-suppression loop. Its disinhibition (lesion or stimulation) quiets the ballism/dystonic overflow that loss of subthalamic control produces.
The functional record names the mechanism and its clinical weight: disinhibition of this loop is the chorea story — Huntington's loses these neurons and the brake lifts. The decoded profile is motor and basal-ganglia vocabulary, plus interoceptive pain (the pallidum's rare primary-pain findings). No graded instrument is assigned — the deep nuclei's levers are the behavioural batteries their circuits execute (stop-signal, WCST — recorded on the caudate's dossier).
*— {'source': 'Gazzaniga, Ivry & Mangun', 'work': 'Cognitive Neuroscience: The Biology of the Mind, 4th ed., W. W. Norton', 'kind': 'textbook', 'locator': 'ch. 8, Action'}*
Putamen (1,453 shared studies), claustrum (1,030), thalamus (973), SMA (794) — the indirect pathway's input and output neighbors, co-activating as the loop they form.
Co-activation partners of record: Putamen:1453, Claustrum:1030, Thalamus:973, Putamen:809, Supplementary motor area:794, Globus pallidus, external segment:787, Thalamus:738, Cingulate gyrus, anterior:693.
Chorea: the indirect pathway's disinhibition made visible — Huntington's pallidal degeneration lifts the brake cell by cell. The pallidum's other failure-modes (drug-induced, vascular) complete the movement-disorder chapter this nucleus opens.
10.1016/S0896-6273(00)80475-410.1016/S0896-6273(00)80715-110.1016/S0006-3223(99)00056-61173 studies total touch this region in the Neurosynth corpus of record; the full literature lives beside this dossier.
Candidate levers (Neurosynth-decoded terms — motor(action-motor), movement(action-motor), basal ganglia(anatomy-reference), ganglia(anatomy-reference), basal(anatomy-reference), movements(action-motor), putamen(anatomy-reference), pain(interoception) …) are the foundation for the thousands of instruments to come; they are ungraded by law.
Putamen:1453, Claustrum:1030, Thalamus:973, Putamen:809 — each name is a dossier stop in this explorer.